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Employee and Consultant Equity-Based Compensation (Tables)
12 Months Ended
Dec. 31, 2015
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Stock Option Activity
The following table summarizes option activity under all plans during the years ending December 31, 2015 and December 31, 2014 and shows the exercisable shares as of December 31, 2015:

Stock Option Activity
 
Number of Shares
Weighted Average Exercise Price per Share
Options Outstanding January 1, 2014
5,185,086

$
3.45

Granted
769,055

16.22

Forfeited
(13,678
)
13.06

Exercised
(311,737
)
2.96

Expired


Options Outstanding December 31, 2014
5,628,726

5.20

Granted
717,833

20.59

Forfeited
(54,505
)
11.71

Exercised
(124,884
)
6.44

Expired


Options Outstanding December 31, 2015
6,167,170

6.91

Exercisable December 31, 2015
1,536,520

7.11

Black-Scholes Assumptions for Option Granted
The table below summarizes the resulting weighted average inputs used to calculate the estimated fair value of options awarded for during the periods shown below:

Black-Scholes Assumptions for Option Granted
 
12 months
12 months
12 months
 
12/31/2015
12/31/2014
12/31/2013
Expected term (in years)
6.26

6.25

6.28

Volatility
91
%
96
%
97
%
Expected dividends



Risk free interest rates
1.7
%
1.9
%
1.5
%
Estimated forfeitures
5.6
%
0.4
%
14.0
%
Weighted average fair value
$
16.69

$
12.63

$
6.05

Stock Option Supplemental Information
The following table shows summary information for outstanding options, options that are exercisable (vested) and outstanding options that are either vested or expected to vest as of December 31, 2015:

Stock Option Supplemental Information
 
Options
Outstanding
Options
Exercisable
Options Vested and Expected to Vest
Number of options
6,167,170

1,536,520

6,088,562

Weighted average remaining contractual term (in years)
7.19

7.18

7.18

Weighted average exercise price
$
6.91

$
7.11

$
6.80

Weighted average fair value
$
5.43

$
5.48

$
5.34

Aggregate intrinsic value (in thousands)
$
86,102

$
21,734

$
85,804

Restricted Stock Activity
The following table summarizes restricted stock activity during the years ending December 31, 2015 and December 31, 2014:

Restricted Stock Activity
 
Number of Shares
Weighted Average Grant Date Fair Value per Share
Restricted stock outstanding December 31, 2014


Granted
40,250

20.91

Forfeited


Vested/released


Restricted stock outstanding December 31, 2015
40,250

20.91

Equity-Based Compensation Expense and Tax Benefit
The expense and tax benefits recognized on Company’s Statements of Operations and Comprehensive Loss related to options is summarized below (in thousands):

Equity-Based Compensation Expenses and Tax Benefit
(in thousands)
 
12 months
12 months
12 months
 
12/31/2015
12/31/2014
12/31/2013
Research and development
$
2,479

$
4,334

$
1,655

Sales, general and administrative
5,909

5,290

2,173

Equity-based compensation expense
8,388

9,624

3,828

Recognized tax benefit
$

$

$