Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2015	Sep. 30, 2014	Sep. 30, 2015	Sep. 30, 2014
Revenues:
Licensing and royalty revenues	$ 16	$ 16	$ 49	$ 43
Product sales	76		76
Total revenues	92	$ 16	125	$ 43
Costs and expenses:
Research and development	6,499	5,949	20,003	14,074
Sales, general and administrative	4,332	2,625	11,953	8,116
Amortization	3	18	8	56
Depreciation	465	251	1,194	536
Total costs and expenses	11,299	8,843	33,158	22,782
Loss from operations	(11,207)	(8,827)	(33,033)	(22,739)
Interest expense	(1)	(2)	(2)	(5)
Interest and dividend income	22	15	53	49
Total other income	21	13	51	44
Net loss before income taxes	$ (11,186)	$ (8,814)	(32,982)	(22,695)
Benefit from income taxes			647	527
Net loss	$ (11,186)	$ (8,814)	$ (32,335)	$ (22,168)
Basic and diluted net loss per share	$ (0.25)	$ (0.20)	$ (0.72)	$ (0.51)
Weighted average shares outstanding	44,727	44,583	44,685	43,293
Other comprehensive loss:
Net loss	$ (11,186)	$ (8,814)	$ (32,335)	$ (22,168)
Net unrealized loss on available-for-sale investments	(3)	(17)	(6)	(11)
Comprehensive loss	$ (11,189)	$ (8,831)	$ (32,341)	$ (22,179)