Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Cash flows from operating activities:
Net loss	$ (83,840,000)	$ (49,706,000)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	3,915,000	3,010,000
Accretion of (discount) premium on investments	(13,000)	55,000
Stock-based compensation	10,194,000	5,954,000
Non-cash interest expense related to sale of future royalties	988,000	1,137,000
Non-cash revenue related to sale of future royalties	(152,000)	(908,000)
Change in operating assets and liabilities:
Accounts receivable	71,000	144,000
Prepaid expenses and other assets	(4,037,000)	(3,570,000)
Accounts payable	2,528,000	1,483,000
Other accrued liabilities	4,719,000	(1,617,000)
Net cash used in operating activities	(65,627,000)	(44,018,000)
Cash flows from investing activities:
Purchase of property and equipment	(5,700,000)	(4,142,000)
Cash paid for right-of-use assets	(5,038,000)	0
Purchases of investments	(48,178,000)	(41,278,000)
Proceeds from maturities of investments	22,700,000	4,500,000
Net cash used in investing activities	(36,216,000)	(40,920,000)
Cash flows from financing activities:
Net proceeds from issuance of common stock through ATM facilities	8,650,000	122,210,000
Proceeds from issuance of common stock upon exercise of warrants	2,000	1,849,000
Proceeds from issuance of common stock upon exercise of stock options	214,000	1,240,000
Net cash provided by financing activities	8,866,000	125,299,000
Net (decrease) increase in cash and cash equivalents	(92,977,000)	40,361,000
Cash and cash equivalents at beginning of the period	143,745,000	126,870,000
Cash and cash equivalents at end of the period	50,768,000	167,231,000
Supplemental disclosure of non-cash investing and financing activity:
Operating lease liabilities arising from obtaining right-of-use assets	9,997,000	6,939,000
Lease-related assets and liabilities derecognized on early termination and modification of leases	0	235,000
Acquisition of property and equipment included in accounts payable and accrued expenses	$ 1,738,000	$ 289,000