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Note 9 - Stockholders' Equity (Tables)
3 Months Ended
Mar. 31, 2021
Notes Tables  
Schedule of Common Stock Reserved for Issuance [Table Text Block]
  

March 31, 2021

  

December 31, 2020

 
         

Options issued and outstanding

  7,764,164   6,813,033 

Available for future grants of equity awards

  67,863   1,230,863 

Common stock warrants

  414,252   1,244,974 

Total

  8,246,279   9,288,870 
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]

Securities into which warrants are convertible

 

Warrants outstanding

  

Exercise Price

 

Expiration Date

          

Common Stock

  5,000  $0.30 

September 2024

Common Stock

  225,966  $1.10 

April 2024

Common Stock

  26,515  $1.375 

April 2024

Common Stock

  29,150  $2.50 

March 2025

Common Stock

  100,532  $3.125 

February 2025

Common Stock

  16,175  $3.125 

March 2024

Common Stock

  10,914  $22.99 

December 2026

Total

  414,252