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Note 7 - Liabilities Related to Sale of Future Royalties (Tables)
 12 Months Ended
Dec. 31, 2020
Notes Tables  
Deferred Revenue, by Arrangement, Disclosure [Table Text Block]
Total liability related to sale of future royalties, start of year
   $
16,332
  
Non-cash royalty revenue paid to HCRP
    
(3,277
 )
Non-cash interest expense recognized
    
1,874
  
Total liability related to sale of future royalties, end of year
    
14,929
  
Current portion
    
(2,779
 )
Long-term portion
   $
12,150