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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Cash flows from operating activities:    
Net loss $ (18,359,000) $ (12,236,000)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,846,000 2,854,000
Stock-based compensation 3,871,000 490,000
Non-cash interest expense 93,000
Non-cash interest expense related to sale of future royalties 1,401,000 1,560,000
Non-cash revenue related to sale of future royalties (3,027,000) (3,147,000)
Change in operating assets and liabilities:    
Accounts receivable 3,369,000 1,237,000
Prepaid expenses and other assets (1,384,000) 164,000
Accounts payable 810,000 136,000
Other accrued liabilities (1,511,000) (449,000)
Net cash used in operating activities (12,984,000) (9,298,000)
Cash flows from investing activities:    
Purchase of property and equipment (321,000) (838,000)
Proceeds from sale of equipment 3,000
Net cash used in investing activities (318,000) (838,000)
Cash flows from financing activities:    
Proceeds from issuance of common stock upon exercise of pre-funded warrants 1,083,000
Proceeds from issuance of common stock upon exercise of common stock warrants 25,951,000
Proceeds from issuance of common stock upon exercise of stock options 402,000
Disgorgement of short-swing profits, net of costs 652,000
Repayment of principal on secured promissory note payable to Oxford Finance (1,250,000)
Net cash provided by financing activities 133,214,000 18,188,000
Net increase in cash and cash equivalents 119,912,000 8,052,000
Cash, cash equivalents and restricted cash at beginning of the period 13,526,000 11,506,000
Cash, cash equivalents and restricted cash at end of the period 133,438,000 19,558,000
Supplemental disclosure of cash flow information:    
Interest paid 195,000
Supplemental disclosure of non-cash financing activity:    
Issuance of warrants to placement agent’s representatives 453,000 100,000
Issuance of warrants to underwriters’ designees 830,000
Operating lease liabilities arising from obtaining right-of-use assets 1,022,000 1,929,000
Acquisition of property and equipment included in accounts payable 213,000 3,000
The March 2020 Offering [Member]    
Cash flows from financing activities:    
Net proceeds from issuance of securities 9,175,000 2,540,000
ATM Program [Member]    
Cash flows from financing activities:    
Net proceeds from issuance of securities 97,034,000
The April 2019 Offering [Member]    
Cash flows from financing activities:    
Net proceeds from issuance of securities in underwritten offering 8,074,000
The September 2019 Offering [Member]    
Cash flows from financing activities:    
Net proceeds from issuance of securities in underwritten offering $ 7,741,000