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Note 7 - Liabilities Related to the Sale of Future Royalties (Tables)
 12 Months Ended
Dec. 31, 2019
Notes Tables  
Deferred Revenue, by Arrangement, Disclosure [Table Text Block]
Total liability related to the sale of future royalties, start of year
   $
17,741
  
Non-cash royalty revenue paid to HCRP
    
(3,482
 )
Non-cash interest expense recognized
    
2,073
  
Total liability related to the sale of future royalties, end of year
    
16,332
  
Current portion
    
(2,916
 )
Long-term portion
   $
13,416