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Note 12 - Net Loss Per Share Attributable to Common Stockholders (Tables)
6 Months Ended
Jun. 30, 2019
Notes Tables  
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
   
Three Months Ended June 30,
   
Six Months Ended June 30,
 
   
2019
   
2018
   
2019
   
2018
 
                                 
Net loss
  $
(5,637
)   $
(8,871
)   $
(6,976
)   $
(6,557
)
                                 
Series B and C preferred dividend
   
     
     
     
(339
)
                                 
Net loss attributable to common stockholders – diluted calculation
  $
(5,637
)   $
(8,871
)   $
(6,976
)   $
(6,896
)
                                 
Shares used to compute net loss per share – basic and diluted
   
14,597,446
     
7,141,189
     
10,969,473
     
5,477,265
 
                                 
Net loss per share – basic and diluted
  $
(0.39
)   $
(1.24
)   $
(0.64
)   $
(1.26
)
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
Three Months Ended June 30,
   
Six Months Ended June 30,
 
   
2019
   
2018
   
2019
   
2018
 
                                 
Options to purchase common stock
   
1,561,067
     
878,555
     
1,212,654
     
765,702
 
                                 
Warrants to purchase common stock
   
11,802,695
     
10,794
     
5,944,948
     
8,230
 
                                 
Warrant to purchase convertible preferred stock
   
     
     
     
1,797
 
                                 
Series B and C convertible preferred stock outstanding, including cumulative dividends
   
     
     
     
431,064
 
                                 
Series A convertible preferred stock outstanding
   
     
     
     
24,723
 
                                 
Convertible promissory notes, related party (as converted)
   
     
     
     
373,388
 
                                 
Total potentially dilutive securities excluded from denominator of the diluted earnings per share computation
   
13,363,762
     
889,349
     
7,157,602
     
1,604,904