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Note 6 - Liabilities Related to Sale of Future Royalties (Tables)
 6 Months Ended
Jun. 30, 2019
Notes Tables  
Deferred Revenue, by Arrangement, Disclosure [Table Text Block]
Total liability related to sale of future royalties, start of period
   $
17,741
  
Non-cash royalty revenue paid to HCRP
    
(3,132
 )
Non-cash interest expense recognized
    
1,060
  
Total liability related to sale of future royalties, end of period
    
15,669
  
Current portion
    
(3,150
 )
Long-term portion
   $
12,519