<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001945228</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000721371</issuerCik>
      <issuerName>Cardinal Health, Inc</issuerName>
      <secFileNumber>001-11373</secFileNumber>
      <issuerAddress>
        <com:street1>7000 Cardinal Place</com:street1>
        <com:city>dublin</com:city>
        <com:stateOrCountry>OH</com:stateOrCountry>
        <com:zipCode>43017</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>614-757-5000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Michelle Greene</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill</name>
        <address>
          <com:street1>8890 Lyra Dr 5th Flr</com:street1>
          <com:city>Columbus</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>43240</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2746</noOfUnitsSold>
      <aggregateMarketValue>627386.62</aggregateMarketValue>
      <noOfUnitsOutstanding>235316016</noOfUnitsOutstanding>
      <approxSaleDate>02/27/2026</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>common</securitiesClassTitle>
      <acquiredDate>08/15/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted stock vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Cardinal Health, Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1973</amountOfSecuritiesAcquired>
      <paymentDate>08/15/2024</paymentDate>
      <natureOfPayment>na</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>common</securitiesClassTitle>
      <acquiredDate>03/15/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted stock vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Cardinal Health, Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>773</amountOfSecuritiesAcquired>
      <paymentDate>03/15/2024</paymentDate>
      <natureOfPayment>na</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>02/27/2026</noticeDate>
      <signature>Michelle Green</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
