-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 JtCL0YK1295Tc3J1DIblI/OPea0VA1EH5bo3vB4FzcPhRI60lLlVMoVBxLPKJWsh
 +YVRUmSllwwqyoidOObp6Q==

<SEC-DOCUMENT>0001179110-10-017516.txt : 20101214
<SEC-HEADER>0001179110-10-017516.hdr.sgml : 20101214
<ACCEPTANCE-DATETIME>20101214174329
ACCESSION NUMBER:		0001179110-10-017516
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20101214
FILED AS OF DATE:		20101214
DATE AS OF CHANGE:		20101214

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			HOPTRY ROBERT E
		CENTRAL INDEX KEY:			0001256236

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-12422
		FILM NUMBER:		101251527

	MAIL ADDRESS:	
		STREET 1:		810 WOODSIDE DR
		CITY:			GREENBERG
		STATE:			IN
		ZIP:			47240

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MAINSOURCE FINANCIAL GROUP
		CENTRAL INDEX KEY:			0000720002
		STANDARD INDUSTRIAL CLASSIFICATION:	STATE COMMERCIAL BANKS [6022]
		IRS NUMBER:				351562245
		STATE OF INCORPORATION:			IN
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		201 N BROADWAY
		STREET 2:		PO BOX 87
		CITY:			GREENSBURG
		STATE:			IN
		ZIP:			47240
		BUSINESS PHONE:		8126630157

	MAIL ADDRESS:	
		STREET 1:		201 NORTH BROADWAY
		STREET 2:		P O BOX 87
		CITY:			GREENSBURG
		STATE:			IN
		ZIP:			47240

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	INDIANA UNITED BANCORP
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>FORM 4 -
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-12-14</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000720002</issuerCik>
        <issuerName>MAINSOURCE FINANCIAL GROUP</issuerName>
        <issuerTradingSymbol>MSFG</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001256236</rptOwnerCik>
            <rptOwnerName>HOPTRY ROBERT E</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>810 WOODSIDE DR.</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>GREENSBURG</rptOwnerCity>
            <rptOwnerState>IN</rptOwnerState>
            <rptOwnerZipCode>47240</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <officerTitle></officerTitle>
            <otherText>Chairman</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2010-12-14</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>4000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>10.5</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>175111</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2591</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Spouse IRA</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <remarks>As authorized by Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>Robert E. Hoptry</signatureName>
        <signatureDate>2010-12-14</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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