Item 4 is hereby amended and supplemented by the addition of the following: As previously disclosed, the Reporting Persons are engaged in a solicitation to oppose stockholder approval of the Merger Agreement Proposal and the Compensation Proposal at the Special Meeting, which has been adjourned until November 6, 2025. In connection with the Issuer's solicitation and consistent with rights of stockholders of the Issuer under the Merger Agreement and applicable law, Broadwood Partners has determined to exercise its appraisal rights for the 13,519,491 Shares it beneficially owns, of which 100 Shares are held in record name, pursuant to Section 262 of the General Corporation Law of the State of Delaware ("Section 262"). On October 22, 2025 and October 23, 2025, prior to the taking of the vote on the Proposed Merger and at the request of Broadwood Partners, Cede & Co., the stockholder of record for the 13,519,391 Shares beneficially owned by Broadwood Partners, sent a written demand, on behalf of Broadwood Partners, for appraisal of the 13,519,391 Shares to the Issuer in connection with the Proposed Merger to be voted on at the Special Meeting (the "Cede & Co. Appraisal Demand"). Also on October 22, 2025 and October 23, 2025, prior to the taking of the vote on the Proposed Merger, Broadwood Partners sent a written demand for appraisal of the 100 Shares it owns of record to the Issuer in connection with the Proposed Merger to be voted on at the Special Meeting (the "Broadwood Partners Appraisal Demand" and together with the Cede & Co. Appraisal Demand, the "Appraisal Demands"). The submission of the Appraisal Demands will have no effect on the outcome of the stockholder vote on the Merger Agreement Proposal or the Compensation Proposal at the Special Meeting. Broadwood Partners reserves all of its rights related to the Appraisal Demands, including, but not limited to, the right under Section 262 to withdraw the Broadwood Partners Appraisal Demand and to request and cause Cede & Co. to withdraw the Cede & Co. Appraisal Demand at any time prior to, or within 60 days after, the Effective Time (as defined in the Merger Agreement).

Item 6 is hereby amended and supplemented by the addition of the following: As a result of the submission of the Appraisal Demands, Broadwood Partners may become entitled to receive payment in cash, constituting the "fair value," in exchange for the 13,519,491 Shares it beneficially owns upon a decree by the Delaware Court of Chancery. The information set forth in Item 4 of this Amendment No. 40 is incorporated herein by reference.