<?xml version="1.0" encoding="us-ascii"?><InstanceReport xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><Version>2.4.0.8</Version><ReportLongName>005 - Disclosure - Note 1 - Significant Accounting Policies</ReportLongName><DisplayLabelColumn>true</DisplayLabelColumn><ShowElementNames>false</ShowElementNames><RoundingOption /><HasEmbeddedReports>false</HasEmbeddedReports><Columns><Column FlagID="0"><Id>1</Id><IsAbstractGroupTitle>false</IsAbstractGroupTitle><LabelSeparator>

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</LabelSeparator><Level>1</Level><ElementName>us-gaap_AccountingPoliciesAbstract</ElementName><ElementPrefix>us-gaap_</ElementPrefix><IsBaseElement>true</IsBaseElement><BalanceType>na</BalanceType><PeriodType>duration</PeriodType><IsReportTitle>false</IsReportTitle><IsSegmentTitle>false</IsSegmentTitle><IsCalendarTitle>false</IsCalendarTitle><IsEquityPrevioslyReportedAsRow>false</IsEquityPrevioslyReportedAsRow><IsEquityAdjustmentRow>false</IsEquityAdjustmentRow><IsBeginningBalance>false</IsBeginningBalance><IsEndingBalance>false</IsEndingBalance><IsReverseSign>false</IsReverseSign><FootnoteIndexer /><Cells><Cell FlagID="0" ContextID="" UnitID=""><Id>1</Id><IsNumeric>false</IsNumeric><IsRatio>false</IsRatio><DisplayZeroAsNone>false</DisplayZeroAsNone><NumericAmount>0</NumericAmount><RoundedNumericAmount>0</RoundedNumericAmount><NonNumbericText /><FootnoteIndexer /><CurrencyCode /><CurrencySymbol /><IsIndependantCurrency>false</IsIndependantCurrency><ShowCurrencySymbol>false</ShowCurrencySymbol><DisplayDateInUSFormat>false</DisplayDateInUSFormat></Cell></Cells><ElementDataType>xbrli:stringItemType</ElementDataType><SimpleDataType>string</SimpleDataType><IsTotalLabel>false</IsTotalLabel><UnitID>0</UnitID><Label>Accounting Policies [Abstract]</Label></Row><Row FlagID="0"><Id>2</Id><IsAbstractGroupTitle>false</IsAbstractGroupTitle><LabelSeparator>

</LabelSeparator><Level>2</Level><ElementName>us-gaap_SignificantAccountingPoliciesTextBlock</ElementName><ElementPrefix>us-gaap_</ElementPrefix><IsBaseElement>true</IsBaseElement><BalanceType>na</BalanceType><PeriodType>duration</PeriodType><IsReportTitle>false</IsReportTitle><IsSegmentTitle>false</IsSegmentTitle><IsCalendarTitle>false</IsCalendarTitle><IsEquityPrevioslyReportedAsRow>false</IsEquityPrevioslyReportedAsRow><IsEquityAdjustmentRow>false</IsEquityAdjustmentRow><IsBeginningBalance>false</IsBeginningBalance><IsEndingBalance>false</IsEndingBalance><IsReverseSign>false</IsReverseSign><PreferredLabelRole>terseLabel</PreferredLabelRole><FootnoteIndexer /><Cells><Cell FlagID="0" ContextID="c4_From30Sep2012To29Jun2013" UnitID=""><Id>1</Id><IsNumeric>false</IsNumeric><IsRatio>false</IsRatio><DisplayZeroAsNone>false</DisplayZeroAsNone><NumericAmount>0</NumericAmount><RoundedNumericAmount>0</RoundedNumericAmount><NonNumbericText>&lt;p style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; MARGIN: 0pt" id="PARA1299"&gt;

      &lt;font id="clearSpaces-105"&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;&lt;b&gt;1.&amp;#160;&amp;#160;

      SIGNIFICANT ACCOUNTING POLICIES&lt;/b&gt;&lt;/font&gt;&lt;/font&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;&lt;/font&gt;

    &lt;/p&gt;&lt;br/&gt;&lt;p style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; MARGIN: 0pt" id="PARA1301"&gt;

      &lt;font id="clearSpaces-107"&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;Span-America

      Medical Systems, Inc., a South Carolina corporation (the

      &amp;#8220;Company,&amp;#8221; &amp;#8220;Span,&amp;#8221;

      &amp;#8220;Span-America,&amp;#8221; &amp;#8220;we,&amp;#8221;

      &amp;#8220;us&amp;#8221; or &amp;#8220;our&amp;#8221;), has prepared the

      accompanying unaudited financial statements in accordance

      with accounting principles generally accepted in the United

      States of America for interim financial information and with

      the instructions to Form 10-Q and Article 10 of Regulation

      S-X. Accordingly, they do not include all of the information

      and footnotes required by accounting principles generally

      accepted in the United States of America for complete

      financial statements. In our opinion, all adjustments

      (consisting only of normal recurring accruals) considered

      necessary for a fair presentation have been included.

      Operating results for the nine-month period ended June 29,

      2013 are not necessarily indicative of the results that may

      be expected for the fiscal year ending September 28, 2013.

      For further information, refer to our Annual Report on Form

      10-K for the fiscal year ended September 29,

      2012.&lt;/font&gt;&lt;/font&gt;

    &lt;/p&gt;&lt;br/&gt;&lt;p style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; MARGIN: 0pt" id="PARA1303"&gt;

      &lt;font id="clearSpaces-109"&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;&lt;b&gt;Principles

      of Consolidation&lt;/b&gt;&lt;/font&gt;&lt;/font&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;&lt;/font&gt;

    &lt;/p&gt;&lt;br/&gt;&lt;p style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; MARGIN: 0pt" id="PARA1304"&gt;

      &lt;font id="clearSpaces-110"&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;The

      consolidated financial statements include the accounts of the

      Company and Span Medical Products Canada Inc., a British

      Columbia corporation (&amp;#8220;Span-Canada&amp;#8221;), its

      wholly-owned subsidiary. Significant inter-company accounts

      and transactions have been eliminated.&lt;/font&gt;&lt;/font&gt;

    &lt;/p&gt;&lt;br/&gt;&lt;p style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; MARGIN: 0pt" id="PARA1306"&gt;

      &lt;font id="clearSpaces-112"&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;&lt;b&gt;Foreign

      Currency Translation&lt;/b&gt;&lt;/font&gt;&lt;/font&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;&lt;/font&gt;

    &lt;/p&gt;&lt;br/&gt;&lt;p style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; MARGIN: 0pt" id="PARA1307"&gt;

      &lt;font id="clearSpaces-113"&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;The

      assets and liabilities of Span-Canada, operating under the

      name &amp;#8220;M.C. Healthcare Products,&amp;#8221; which uses the

      Canadian dollar as its functional currency, are translated

      into U.S. dollars at the quarter-end exchange rate. Revenues

      and expenses are translated at weighted average exchange

      rates. The resulting translation adjustments are recorded as

      a separate component of shareholders&amp;#8217;

      equity.&lt;/font&gt;&lt;/font&gt;

    &lt;/p&gt;&lt;br/&gt;&lt;p style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; MARGIN: 0pt" id="PARA1309"&gt;

      &lt;font id="clearSpaces-115"&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;&lt;b&gt;Recently

      Issued Accounting Standards&lt;/b&gt;&lt;/font&gt;&lt;/font&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;&lt;/font&gt;

    &lt;/p&gt;&lt;br/&gt;&lt;p style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; MARGIN: 0pt" id="PARA1310"&gt;

      &lt;font id="clearSpaces-116"&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;Accounting

      standards that have been issued or proposed by the Financial

      Accounting Standards Board (&amp;#8220;FASB&amp;#8221;) or other

      standards-setting bodies that do not require adoption until a

      future date are not expected to have a material impact on our

      financial statements upon adoption.&lt;/font&gt;&lt;/font&gt;

    &lt;/p&gt;&lt;br/&gt;&lt;p style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; MARGIN: 0pt" id="PARA1312"&gt;

      &lt;font id="clearSpaces-118"&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;&lt;b&gt;Stock-Based

      Compensation&lt;/b&gt;&lt;/font&gt;&lt;/font&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;&lt;/font&gt;

    &lt;/p&gt;&lt;br/&gt;&lt;p style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; MARGIN: 0pt" id="PARA1313"&gt;

      &lt;font id="clearSpaces-119"&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;We

      measure and recognize compensation expense for all

      stock-based payments at fair value. Stock-based payments

      include stock option grants. We have granted options to

      purchase common stock to some of our employees under various

      plans at prices equal to the market value of the stock on the

      dates the options were granted. New shares of stock are

      issued upon share option exercise. We do not have treasury

      stock.&lt;/font&gt;&lt;/font&gt;

    &lt;/p&gt;&lt;br/&gt;&lt;p style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; MARGIN: 0pt" id="PARA1315"&gt;

      &lt;font id="clearSpaces-121"&gt;&lt;font style="FONT-FAMILY: Times New Roman, Times, serif; FONT-SIZE: 10pt"&gt;The

      fair value of each option grant is estimated on the date of

      grant using the Black-Scholes option pricing model with the

      following weighted average assumptions for grants made in

      fiscal 2011: risk-free interest rate of 2.54%; dividend yield

      of 2.5%; volatility factor of the expected market price of

      our common stock of 43.02%; and a weighted average expected

      life of the options of 9.0 years. No options were granted

      during the nine months ended June 29, 2013 or during fiscal

      year 2012.&lt;/font&gt;&lt;/font&gt;

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