MORGAN STANLEY VARIABLE INVESTMENT SERIES

522 Fifth Avenue

New York, New York 10036

VIA EDGAR

May 3, 2011

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

Re:	Morgan Stanley Variable Investment Series
	File Nos. 2-82510; 811-3692

Ladies and Gentlemen:

On behalf of Morgan Stanley Variable Investment Series (“Registrant”) and pursuant to Rule 497(j) under the Securities Act of 1933, as amended (the “Securities Act”), I hereby certify that (i) the prospectuses and statement of additional information contained in Post-Effective Amendment No. 48 to Registrant’s Registration Statement on Form N-1A, filed on April 13, 2011, constituting the most recent amendment to this Registration Statement (“the Amendment”), that would have been filed pursuant to Rule 497(c) under the Securities Act would not have differed from those contained in the Amendment, and (ii) the text of the Amendment was filed electronically with the Securities and Exchange Commission on April 13, 2011, accession number 0001104659-11-019809.

If you have any questions, please feel free to contact me at 212.296.6961 (tel) or 646.225.5505 (fax).

	Very truly yours,
	/s/ Joanne Antico
	Joanne Antico
	Assistant Secretary
Enclosures
cc: Stefanie V. Chang Yu, Esq.