X0303 4 2010-12-23 0000716054 CYPRESS BIOSCIENCE INC CYPB 0001055666 KRANZLER JAY D 4350 EXECUTIVE DRIVE SUITE 214 SAN DIEGO CA 92121 1 1 0 0 CEO Common Stock 2010-12-23 4 M 0 152464 3.25 A 249206 I By Trust Common Stock 2010-12-23 4 S 0 152464 6.45 D 96742 I By Trust Common Stock 625 D Common Stock 398692 I By 401(k) Plan Stock Options (right to buy) 3.25 2010-12-23 4 M 0 152464 0 D 2012-04-29 Common Stock 152464 0 D The weighted average sale price for the transaction reported was $6.4501, the range of prices were between $6.45 and $6.455. Upon request by the SEC staff, the issuer, or any security holder of the issuer, full information regarding the number of shares purchased or sold at each separate price will be provided. The shares subject to the option are fully vested Between January 1, 2010 and December 14, 2010, 196,440 shares of Common Stock were transfered into the Cypress Bioscience, Inc. 401(k) plan, of which the Reporting Person is the trustee and has voting power over such shares. /s/ Sabrina Johnson Attorney-in-Fact 2010-12-27