X0303 4 2009-08-03 0000716054 CYPRESS BIOSCIENCE INC CYPB 0001055666 KRANZLER JAY D 4350 EXECUTIVE DRIVE SUITE 214 SAN DIEGO CA 92121 1 1 0 0 CEO Common Stock 2009-08-03 4 M 0 75000 2.51 A 171742 I By Trust Common Stock 2009-08-03 4 S 0 75000 8.6913 D 96742 I By Trust Common Stock 625 D Common Stock 204412 I By 401(k) Plan Stock Options (right to buy) 2.51 2009-08-03 4 M 0 75000 0 D 2007-03-27 2013-03-27 Common Stock 75000 37874 D The sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on February 1, 2009. The weighted average sale price for the transaction reported was $8.6913, the range of prices were between $8.53 and $8.95. Upon request by the SEC staff, the issuer, or any security holder of the issuer, full information regarding the number of shares purchased or sold at each separate price will be provided. The shares subject to the option were fully vested as of March 27, 2007. Includes 72,187 shares acquired on June 30, 2009 under the Issuer's 401(k) Plan, of which the Reporting Person is the Trustee and has voting power over such shares. /s/ Sabrina Johnson Attorney-in-Fact 2009-08-04