X0303 4 2009-02-02 0000716054 CYPRESS BIOSCIENCE INC CYPB 0001055666 KRANZLER JAY D 4350 EXECUTIVE DRIVE SUITE 214 SAN DIEGO CA 92121 1 1 0 0 CEO Common Stock 2009-02-02 4 M 0 14906 2.51 A 111648 I By Trust Common Stock 2009-02-02 4 M 0 60094 2.51 A 171742 I By Trust Common Stock 2009-02-02 4 S 0 5000 8.50 D 166742 I By Trust Common Stock 2009-02-02 4 S 0 4000 8.52 D 162742 I By Trust Common Stock 2009-02-02 4 S 0 1000 8.53 D 161742 I By Trust Common Stock 2009-02-02 4 S 0 2000 8.54 D 159742 I By Trust Common Stock 2009-02-02 4 S 0 2200 8.55 D 157542 I By Trust Common Stock 2009-02-02 4 S 0 2000 8.57 D 155542 I By Trust Common Stock 2009-02-02 4 S 0 2000 8.573 D 153542 I By Trust Common Stock 2009-02-02 4 S 0 2000 8.5745 D 151542 I By Trust Common Stock 2009-02-02 4 S 0 4000 8.58 D 147542 I By Trust Common Stock 2009-02-02 4 S 0 3000 8.5866 D 144542 I By Trust Common Stock 2009-02-02 4 S 0 2000 8.587 D 142542 I By Trust Common Stock 2009-02-02 4 S 0 2000 8.5939 D 140542 I By Trust Common Stock 2009-02-02 4 S 0 2000 8.594 D 138542 I By Trust Common Stock 2009-02-02 4 S 0 2000 8.5977 D 136542 I By Trust Common Stock 2009-02-02 4 S 0 1800 8.60 D 134742 I By Trust Common Stock 2009-02-02 4 S 0 2000 8.6005 D 132742 I By Trust Common Stock 2009-02-02 4 S 0 2000 8.6015 D 130742 I By Trust Common Stock 2009-02-02 4 S 0 3000 8.61 D 127742 I By Trust Common Stock 2009-02-02 4 S 0 2000 8.6155 D 125742 I By Trust Common Stock 2009-02-02 4 S 0 2000 8.62 D 123742 I By Trust Common Stock 2009-02-02 4 S 0 2000 8.622 D 121742 I By Trust Common Stock 2009-02-02 4 S 0 5000 8.63 D 116742 I By Trust Common Stock 2009-02-02 4 S 0 5700 8.64 D 111042 I By Trust Common Stock 2009-02-02 4 S 0 10000 8.65 D 101042 I By Trust Common Stock 2009-02-02 4 S 0 300 8.67 D 100742 I By Trust Common Stock 2009-02-02 4 S 0 4000 8.68 D 96742 I By Trust Common Stock 625 D Common Stock 132225 I By 401(k) plan Stock Options (right to buy) 2.51 2009-02-02 4 M 0 14906 0 D 2007-03-27 2013-03-27 Common Stock 14906 0 D Stock Options (right to buy) 2.51 2009-02-02 4 M 0 60094 0 D 2007-03-27 2013-03-27 Common Stock 60094 0 D The sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on February 1, 2009. Includes 7,384 shares acquired on December 31, 2007, 25,748 shares acquired on June 30, 2008 and 23,806 shares acquired on December 31, 2008 under the Issuer's 401(k) Plan, of which the Reporting Person is the Trustee and has voting power over such shares. The shares subject to the option were fully vested as of March 27, 2007. /s/ Denise Wheeler Attorney-in-Fact 2009-02-04