X0202 4 2007-12-24 0000716054 CYPRESS BIOSCIENCE INC CYPB 0001055666 KRANZLER JAY D 4350 EXECUTIVE DRIVE SUITE 325 SAN DIEGO CA 92121 1 1 0 0 CEO Common Stock 2007-12-24 4 S 0 671 11.51 D 17653 I By Trust Common Stock 2007-12-24 4 S 0 729 11.55 D 16924 I By Trust Common Stock 2007-12-24 4 S 0 300 11.56 D 16624 I By Trust Common Stock 2007-12-24 4 S 0 1500 11.57 D 15124 I By Trust Common Stock 2007-12-24 4 S 0 300 11.58 D 14824 I By Trust Common Stock 2007-12-24 4 S 0 400 11.59 D 14424 I By Trust Common Stock 2007-12-24 4 S 0 300 11.60 D 14124 I By Trust Common Stock 2007-12-24 4 S 0 300 11.63 D 13824 I By Trust Common Stock 2007-12-24 4 S 0 1400 11.65 D 12424 I By Trust Common Stock 2007-12-24 4 S 0 1000 11.66 D 11424 I By Trust Common Stock 2007-12-24 4 S 0 1600 11.67 D 9824 I By Trust Common Stock 2007-12-24 4 S 0 700 11.68 D 9124 I By Trust Common Stock 2007-12-24 4 S 0 1899 11.69 D 7225 I By Trust Common Stock 2007-12-24 4 S 0 2201 11.70 D 5024 I By Trust Common Stock 2007-12-24 4 S 0 400 11.71 D 4624 I By Trust Common Stock 2007-12-24 4 S 0 300 11.72 D 4324 I By Trust Common Stock 2007-12-24 4 S 0 24 11.75 D 4300 I By Trust Common Stock 2007-12-24 4 S 0 300 11.76 D 4000 I By Trust Common Stock 2007-12-19 4 G 0 4000 D 0 I By Trust Common Stock 625 D The sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 1, 2007. Gift to an organization not affilitated with the Reporting Person. /s/ Sabrina Martucci Johnson Attorney-in-Fact 2007-12-27