X0202 4 2007-11-26 0000716054 CYPRESS BIOSCIENCE INC CYPB 0001055666 KRANZLER JAY D 4350 EXECUTIVE DRIVE SUITE 325 SAN DIEGO CA 92121 1 1 0 0 CEO Common Stock 2007-11-26 4 S 0 300 11.55 D 18324 I By Trust Common Stock 625 D Common Stock 75173 I By 401(k) plan The sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 1, 2007. Between October 23, 2007 and November 26, 2007, 2,183 shares of Common Stock were transferred out of the Cypress Bioscience, Inc. 401(k) plan, of which the Reporting Person is the trustee and has voting power over such shares. Report 2 of 2 /s/ Denise Wheeler Attorney-in-Fact 2007-11-27