X0202 3 2007-10-26 0 0000716054 CYPRESS BIOSCIENCE INC CYPB 0001279110 WHEELER DENISE 4350 EXECUTIVE DRIVE SUITE 325 SAN DIEGO CA 92121 0 1 0 0 General Counsel Stock Option (right to buy) 5.78 2016-01-02 Common Stock 30000 D Stock Option (right to buy) 7.75 2017-01-02 Common Stock 46060 D 50% of the shares subject to the option shall vest daily and ratably during 2006, and the remaining 50% shall vest daily and ratably over the next three years, such that the option shall be fully vested on January 2, 2010. The shares subject to the option shall vest daily and ratably over four years from the date of grant, such that the option shall be fully vested on January 2, 2011. /s/ Sabrina Martucci Johnson Attorney-in-Fact 2007-11-01