X0202 4 2007-09-24 0000716054 CYPRESS BIOSCIENCE INC CYPB 0001055666 KRANZLER JAY D 4350 EXECUTIVE DRIVE SUITE 325 SAN DIEGO CA 92121 1 1 0 0 CEO Common Stock 2007-09-24 4 S 0 300 14.52 D 93024 I By Trust Common Stock 2007-09-24 4 S 0 400 14.55 D 92624 I By Trust Common Stock 2007-09-24 4 S 0 400 14.56 D 92224 I By Trust Common Stock 2007-09-24 4 S 0 300 14.57 D 91924 I By Trust Common Stock 2007-09-24 4 S 0 200 14.59 D 91724 I By Trust Common Stock 2007-09-24 4 S 0 500 14.60 D 91224 I By Trust Common Stock 2007-09-24 4 S 0 300 14.62 D 90924 I By Trust Common Stock 2007-09-24 4 S 0 1100 14.63 D 89824 I By Trust Common Stock 2007-09-24 4 S 0 300 14.75 D 89524 I By Trust Common Stock 2007-09-24 4 S 0 1000 14.77 D 88524 I By Trust Common Stock 2007-09-24 4 S 0 1200 14.78 D 87324 I By Trust Common Stock 2007-09-24 4 S 0 1700 14.79 D 85624 I By Trust Common Stock 2007-09-24 4 S 0 4100 14.80 D 81524 I By Trust Common Stock 2007-09-24 4 S 0 4100 14.81 D 77424 I By Trust Common Stock 2007-09-24 4 S 0 3498 14.82 D 73926 I By Trust Common Stock 2007-09-24 4 S 0 1871 14.83 D 72055 I By Trust Common Stock 2007-09-24 4 S 0 1931 14.84 D 70124 I By Trust Common Stock 2007-09-24 4 S 0 200 14.85 D 69924 I By Trust Common Stock 2007-09-24 4 S 0 300 14.86 D 69624 I By Trust Common Stock 2007-09-24 4 S 0 300 14.89 D 69324 I By Trust Common Stock 2007-09-24 4 S 0 100 14.91 D 69224 I By Trust Common Stock 2007-09-24 4 S 0 300 14.92 D 68924 I By Trust Common Stock 2007-09-24 4 S 0 300 14.94 D 68624 I By Trust Common Stock 2007-09-24 4 S 0 300 14.97 D 68324 I By Trust Common Stock 625 D Common Stock 80556 I By 401(k) plan The sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 1, 2007. /s/ Denise Wheeler Attorney-in-Fact 2007-09-24