X0202 4 2007-05-29 0000716054 CYPRESS BIOSCIENCE INC CYPB 0001055666 KRANZLER JAY D 4350 EXECUTIVE DRIVE SUITE 325 SAN DIEGO CA 92121 1 1 0 0 CEO Common Stock 2007-05-29 4 S 0 2200 D 171124 I By Trust Common Stock 2007-05-29 4 S 0 3600 D 167524 I By Trust Common Stock 2007-05-29 4 S 0 2300 D 165224 I By Trust Common Stock 2007-05-29 4 S 0 500 D 164724 I By Trust Common Stock 2007-05-29 4 S 0 100 16.64 D 164624 I By Trust Common Stock 2007-05-29 4 S 0 500 D 164124 I By Trust Common Stock 2007-05-29 4 S 0 500 D 163624 I By Trust Common Stock 2007-05-29 4 S 0 300 D 163324 I By Trust Common Stock 2007-05-29 4 S 0 1100 D 162224 I By Trust Common Stock 2007-05-29 4 S 0 1900 D 160324 I By Trust Common Stock 2007-05-29 4 S 0 1700 D 158624 I By Trust Common Stock 2007-05-29 4 S 0 300 D 158324 I By Trust Common Stock 625 D Common Stock 78400 I By 401(k) plan. The sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 12, 2006. Shares were sold at prices ranging from $16.21 to $16.31. Shares were sold at prices ranging from $16.32 to $16.40. Shares were sold at prices ranging from $16.43 to $16.52. Shares were sold at prices ranging from $16.53 to $16.62. Shares were sold at prices ranging from $16.73 to $16.82. Shares were sold at prices ranging from $16.83 to $16.90. Shares were sold at prices ranging from $16.93 to $16.95. Shares were sold at prices ranging from $17.08 to $17.11. Shares were sold at prices ranging from $17.13 to $17.20. Shares were sold at prices ranging from $17.24 to $17.31. Shares were sold at prices ranging from $17.67 to $17.70. Between February 27, 2007 and May 30, 2007, 7,241 shares of Common Stock were transferred out of the Cypress Bioscience, Inc. 401(k) plan, of which the Reporting Person is the trustee and has voting power over such shares. Report 1 of 2 /s/ Sabrina Martucci Johnson Attorney-in-Fact 2007-05-31