X0202 4 2007-03-26 0000716054 CYPRESS BIOSCIENCE INC CYPB 0001055666 KRANZLER JAY D 4350 EXECUTIVE DRIVE SUITE 325 SAN DIEGO CA 92121 1 1 0 0 CEO Common Stock 2007-03-26 4 S 0 300 7.93 D 183024 I By Trust Common Stock 2007-03-26 4 S 0 100 7.95 D 182924 I By Trust Common Stock 2007-03-26 4 S 0 100 7.98 D 182824 I By Trust Common Stock 2007-03-26 4 S 0 400 7.99 D 182424 I By Trust Common Stock 2007-03-26 4 S 0 200 8.00 D 182224 I By Trust Common Stock 2007-03-26 4 S 0 833 8.01 D 181391 I By Trust Common Stock 2007-03-26 4 S 0 200 8.02 D 181191 I By Trust Common Stock 2007-03-26 4 S 0 800 8.03 D 180391 I By Trust Common Stock 2007-03-26 4 S 0 600 8.04 D 179791 I By Trust Common Stock 2007-03-26 4 S 0 35 8.05 D 179756 I By Trust Common Stock 2007-03-26 4 S 0 65 8.06 D 179691 I By Trust Common Stock 2007-03-26 4 S 0 200 8.09 D 179491 I By Trust Common Stock 2007-03-26 4 S 0 467 8.10 D 179024 I By Trust Common Stock 2007-03-26 4 S 0 100 8.14 D 178924 I By Trust Common Stock 2007-03-26 4 S 0 100 8.18 D 178824 I By Trust Common Stock 2007-03-26 4 S 0 200 8.22 D 178624 I By Trust Common Stock 2007-03-26 4 S 0 100 8.24 D 178524 I By Trust Common Stock 2007-03-26 4 S 0 100 8.25 D 178424 I By Trust Common Stock 2007-03-26 4 S 0 100 8.26 D 178324 I By Trust Common Stock 625 D Common Stock 85641 I By 401(k) plan The sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 12, 2006. /s/ Denise Wheeler Attorney-in-Fact 2007-03-28