X0202 4 2007-01-12 0000716054 CYPRESS BIOSCIENCE INC CYPB 0001199104 GENDREAU R MICHAEL 4350 EXECUTIVE DRIVE SUITE 325 SAN DIEGO CA 92121 0 1 0 0 Chief Medical Officer Common Stock 2007-01-12 4 M 0 688 3.25 A 73494 D Common Stock 2007-01-12 4 M 0 731 2.51 A 74225 D Common Stock 2007-01-12 4 S 0 1419 8.1034 D 72806 D Common Stock 2007-01-12 4 S 0 37000 8.1034 D 35806 D Common Stock 2007-01-16 4 M 0 14066 2.60 A 49872 D Common Stock 2007-01-16 4 M 0 25121 3.25 A 74993 D Common Stock 2007-01-16 4 M 0 25742 3.25 A 100735 D Common Stock 2007-01-16 4 M 0 32495 2.51 A 133230 D Common Stock 2007-01-16 4 F 0 33945 8.35 D 99285 D Stock Option (right to buy) 3.25 2007-01-12 4 M 0 688 0 D 2012-04-29 Common Stock 688 25742 D Stock Option (right to buy) 2.51 2007-01-12 4 M 0 731 0 D 2013-03-27 Common Stock 731 32495 D Stock Option (right to buy) 2.60 2007-01-16 4 M 0 14066 0 D 2012-02-12 Common Stock 14066 0 D Stock Option (right to buy) 3.25 2007-01-16 4 M 0 25121 0 D 2012-04-29 Common Stock 25121 0 D Stock Option (right to buy) 3.25 2007-01-16 4 M 0 25742 0 D 2012-04-29 Common Stock 25742 0 D Stock Option (right to buy) 2.51 2007-01-16 4 M 0 32495 0 D 2013-03-27 Common Stock 32495 1803 D The shares subject to the option vested daily and ratably over a period of two years beginning April 29, 2004. 25% of the shares subject to the option vested on March 27, 2003 and the remainder vests daily and ratably over four years such that the option shall be fully vested on March 27, 2007. 25% of the shares subject to the option vested on December 1, 2001 and the remainder vested daily and ratably over four years such that the option was fully vested on December 1, 2005. The shares subject to the option vested daily and ratably over a period of four years beginning April 29, 2002. /s/ Sabrina Martucci Johnson Attorney-in-Fact 2007-01-17