X0202 4 2005-08-22 1 0000716054 CYPRESS BIOSCIENCE INC CYPB 0001055666 KRANZLER JAY D 4350 EXECUTIVE DRIVE SUITE 325 SAN DIEGO CA 92121 1 1 0 0 CEO Common Stock 2005-08-23 4 S 0 700 12.50 D 145100 I By Trust Common Stock 2005-08-23 4 S 0 700 12.52 D 144400 I By Trust Common Stock 2005-08-23 4 S 0 700 12.53 D 143700 I By Trust Common Stock 2005-08-23 4 S 0 700 12.54 D 143000 I By Trust Common Stock 2005-08-23 4 S 0 800 12.63 D 142200 I By Trust Common Stock 2005-08-23 4 S 0 700 12.65 D 141500 I By Trust Common Stock 625 D Common Stock 68724 I By 401(k) plan The shares subject to the option were fully vested as of January 1, 1999. Between July 1, 2005 and August 23, 2005, 7,907 shares of Common Stock were transfered out of the Cypress Bioscience, Inc. 401(k) plan, of which the Reporting Person is the trustee and has voting power over such shares. The sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 14, 2005. 2 of 2 Denise Woolard Attorney-in-Fact 2005-08-24