X0202 4 2005-08-22 1 0000716054 CYPRESS BIOSCIENCE INC CYPB 0001055666 KRANZLER JAY D 4350 EXECUTIVE DRIVE SUITE 325 SAN DIEGO CA 92121 1 1 0 0 CEO Common Stock 2005-08-22 4 M 0 20000 2.50 A 161500 I By Trust Common Stock 2005-08-23 4 M 0 20000 2.50 A 181500 I By Trust Common Stock 2005-08-22 4 S 0 700 12.90 D 180800 I By Trust Common Stock 2005-08-22 4 S 0 800 12.95 D 180000 I By Trust Common Stock 2005-08-22 4 S 0 700 12.98 D 179300 I By Trust Common Stock 2005-08-22 4 S 0 1400 12.99 D 177900 I By Trust Common Stock 2005-08-22 4 S 0 4500 13.00 D 173400 I By Trust Common Stock 2005-08-22 4 S 0 700 13.01 D 172700 I By Trust Common Stock 2005-08-22 4 S 0 800 13.02 D 171900 I By Trust Common Stock 2005-08-22 4 S 0 1600 13.03 D 170300 I By Trust Common Stock 2005-08-22 4 S 0 800 13.05 D 169500 I By Trust Common Stock 2005-08-22 4 S 0 1600 13.06 D 167900 I By Trust Common Stock 2005-08-22 4 S 0 800 13.07 D 167100 I By Trust Common Stock 2005-08-22 4 S 0 800 13.10 D 166300 I By Trust Common Stock 2005-08-22 4 S 0 800 13.11 D 165500 I By Trust Common Stock 2005-08-22 4 S 0 1600 13.13 D 163900 I By Trust Common Stock 2005-08-22 4 S 0 2400 13.15 D 161500 I By Trust Common Stock 2005-08-23 4 S 0 800 12.17 D 160700 I By Trust Common Stock 2005-08-23 4 S 0 800 12.28 D 159900 I By Trust Common Stock 2005-08-23 4 S 0 800 12.29 D 159100 I By Trust Common Stock 2005-08-23 4 S 0 1600 12.30 D 157500 I By Trust Common Stock 2005-08-23 4 S 0 800 12.31 D 156700 I By Trust Common Stock 2005-08-23 4 S 0 800 12.32 D 155900 I By Trust Common Stock 2005-08-23 4 S 0 800 12.33 D 155100 I By Trust Common Stock 2005-08-23 4 S 0 800 12.39 D 154300 I By Trust Common Stock 2005-08-23 4 S 0 2100 12.40 D 152200 I By Trust Common Stock 2005-08-23 4 S 0 1500 12.42 D 150700 I By Trust Common Stock 2005-08-23 4 S 0 700 12.43 D 150000 I By Trust Common Stock 2005-08-23 4 S 0 2800 12.45 D 147200 I By Trust Common Stock 2005-08-23 4 S 0 1400 12.49 D 145800 I By Trust Stock Option (right to buy) 2.50 2005-08-22 4 M 0 20000 0 D 1996-01-19 2006-01-19 Common Stock 20000 180260 D Stock Option (right to buy) 2.50 2005-08-23 4 M 0 20000 0 D 1996-01-19 2006-01-19 Common Stock 20000 160260 D The shares subject to the option were fully vested as of January 1, 1999. The sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 14, 2005. 1 of 2 Denise Woolard Attorney-in-Fact 2005-08-24