X0202 4 2004-12-02 0000716054 CYPRESS BIOSCIENCE INC CYPB 0001199104 GENDREAU R MICHAEL 4350 EXECUTIVE DRIVE SUITE 325 SAN DIEGO CA 92121 0 1 0 0 VP & Chief Medical Officer Common Stock 2004-12-02 4 M 0 2100 2.50 A 2100 D Common Stock 2004-12-02 4 M 0 2500 2.50 A 4600 D Common Stock 2004-12-02 4 M 0 3125 2.50 A 7725 D Common Stock 2004-12-02 4 M 0 10000 2.50 A 17725 D Common Stock 2004-12-02 4 M 0 7477 2.50 A 25202 D Common Stock 2004-12-02 4 M 0 4824 2.50 A 30026 D Common Stock 2004-12-02 4 M 0 9833 1.4062 A 39859 D Common Stock 2004-12-02 4 M 0 12423 2.51 A 52282 D Common Stock 2004-12-02 4 M 0 7045 3.25 A 59327 D Common Stock 2004-12-02 4 S 0 59327 12.5589 D 0 D Stock Option (right to buy) 2.50 2004-12-02 4 M 0 2100 0 D 1995-03-31 1999-01-31 Common Stock 2100 0 D Stock Option (right to buy) 2.50 2004-12-02 4 M 0 2500 0 D 1996-04-29 2006-04-29 Common Stock 2500 0 D Stock Option (right to buy) 2.50 2004-12-02 4 M 0 3125 0 D 1996-04-29 2006-04-29 Common Stock 3125 0 D Stock Option (right to buy) 2.50 2004-12-02 4 M 0 10000 0 D 1996-04-29 2006-04-29 Common Stock 10000 0 D Stock Option (right to buy) 2.50 2004-12-02 4 M 0 7477 0 D 1998-08-10 2006-06-27 Common Stock 7477 0 D Stock Option (right to buy) 2.50 2004-12-02 4 M 0 4824 0 D 1998-08-10 2006-06-27 Common Stock 4824 0 D Stock Option (right to buy) 1.4062 2004-12-02 4 M 0 9833 0 D 2001-03-20 2011-03-20 Common Stock 9833 0 D Stock Option (right to buy) 2.51 2004-12-02 4 M 0 12423 0 D 2003-03-27 2013-03-27 Common Stock 12423 731 D Stock Option (right to buy) 3.25 2004-12-02 4 M 0 7045 0 D 2004-04-29 2012-04-29 Common Stock 7045 688 D The shares subject to the option vested daily and ratably over a period of four years beginning March 31, 1995, and as of January 31, 1999, were fully vested. The shares subject to the option vested 100% as of April 29, 1996. The shares subject to the option vested daily and ratably over a period of four years beginning April 29, 1996, and as of April 29, 1999, were fully vested. The shares subject to the option began vesting August 10, 1998, and as of February 10, 2002, were fully vested. The shares subject to the option began vesting March 21, 2001, and as of December 31, 2002, were fully vested. The shares subject to the option began vesting March 27, 2003, and as of December 1, 2003, 12,423 were fully vested with the remaining 731 options vesting daily and ratably until fully vested as of December 31, 2004. The shares subject to the option vest daily and ratably over a period of two years beginning April 29, 2004 Sabrina Martucci Johnson Attorney-in-Fact 2004-12-03