X0202 4 2004-09-30 0000716054 CYPRESS BIOSCIENCE INC CYPB 0001055666 KRANZLER JAY D 4350 EXECUTIVE DRIVE SUITE 325 SAN DIEGO CA 92121 1 1 0 0 CEO Common Stock 2004-09-30 4 I 0 8143 11.55 D 75757 I 401(k) Common Stock 2004-09-30 4 I 0 4100 11.65 D 71657 I 401(k) Common Stock 2004-09-30 4 I 0 600 11.64 D 71057 I 401(k) Common Stock 2004-09-30 4 I 0 500 11.67 D 70557 I 401(k) Common Stock 2004-09-30 4 I 0 500 11.60 D 70057 I 401(k) Common Stock 2004-09-30 4 I 0 500 11.58 D 69557 I 401(k) Common Stock 2004-09-30 4 I 0 200 11.63 D 69357 I 401(k) Common Stock 2004-09-30 4 I 0 100 11.54 D 69257 I 401(k) Common Stock 2004-10-01 4 M 0 5336 2.50 A 107280 D Common Stock 2004-10-01 4 M 0 60232 2.50 A 167512 D Common Stock 2004-10-01 4 M 0 126113 1.4062 A 293625 D Common Stock 2004-10-01 4 S 0 191681 11.20 D 101944 D Common Stock 2004-10-01 4 S 0 101319 11.20 D 625 D Common Stock 141500 I By Trust Stock Option (right to buy) 2.50 2004-10-01 4 M 0 5336 0 D 1996-01-19 2006-01-19 Common Stock 5336 240260 D Stock Option (right to buy) 2.50 2004-10-01 4 M 0 60232 0 D 2000-01-28 2006-06-27 Common Stock 60232 0 D Stock Option (right to buy) 1.4062 2004-10-01 4 M 0 126113 0 D 2001-03-20 2011-03-20 Common Stock 126113 0 D Includes 4,720 shares acquired on June 30, 2004 under the Issuer's 401(k) Plan, of which the Reporting Person is the Trustee and has voting power over such shares. The 14,643 shares reported as disposed of pursuant to the Issuer's 401(k) Plan were sold on behalf of an affiliate who participates in the Issuer's 401(k) Plan. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed and admission of beneficial ownership of all the reported shares for the purposes of Section 16 or for any other purpose. The shares subject to the option were fully vested as of January 1, 1999. The shares subject to the option were fully vested as of December 31, 2001. The shares subject to the option were fully vested as of March 21, 2003. Sabrina Martucci Johnson Attorney-in-Fact 2004-10-04