X0202 4 2004-06-02 0000716054 CYPRESS BIOSCIENCE INC CYPB 0001199104 GENDREAU R MICHAEL 4350 EXECUTIVE DRIVE SUITE 325 SAN DIEGO CA 92121 0 1 0 0 VP & Chief Medical Officer Common Stock 2004-06-02 4 M 0 6250 2.50 A 19275 D Common Stock 2004-06-02 4 M 0 5023 2.50 A 24298 D Common Stock 2004-06-02 4 M 0 10801 2.50 A 35099 D Common Stock 2004-06-02 4 M 0 6443 1.4062 A 41542 D Common Stock 2004-06-02 4 M 0 35934 2.60 A 77476 D Common Stock 2004-06-02 4 M 0 8355 3.25 A 85831 D Common Stock 2004-06-02 4 F 0 13025 2.50 D 72806 D Stock Option (right to buy) 2.50 2004-06-02 4 M 0 6250 D 1999-01-01 2006-06-27 Common Stock 6250 0 D Stock Option (right to buy) 2.50 2004-06-02 4 M 0 5023 D 1999-08-10 2006-06-27 Common Stock 5023 0 D Stock Option (right to buy) 2.50 2004-06-02 4 M 0 10801 D 2000-01-27 2006-06-27 Common Stock 10801 0 D Stock Option (right to buy) 1.4062 2004-06-02 4 M 0 6443 D 2001-03-20 2011-03-20 Common Stock 6443 0 D Stock Option (right to buy) 2.60 2004-06-02 4 M 0 35934 D 2000-02-12 2012-02-12 Common Stock 35934 14066 D Stock Option (right to buy) 3.25 2004-06-02 4 M 0 8355 D 2002-04-29 2012-04-29 Common Stock 8355 25121 D The shares subject to the option vested 25% after one year, with the remaining options vesting daily and ratably over a period of three years beginning January 1, 1998, and as of January 1, 2002, were fully vested. The shares subject to the option vested 25% after one year, with the remaining options vesting daily and ratably over a period of three years beginning August 10, 1998, and as of August 10, 2002, were fully vested. The shares subject to the option vested daily and ratably over a period of four years beginning January 27, 2000, and as of January 27, 2004, were fully vested. The shares subject to the option vested daily and ratably over a period of two years beginning March 20, 2001, and as of March 19, 2003, were fully vested. The shares subject to the option vest 25% immediately with the remaining options to vest daily and ratably over a period of 4 years such that they are fully vested on December 1, 2005. The shares subject to the option vest daily and ratably over a period of four years beginning April 29, 2002. Not Applicable Sabrina Martucci Johnson Attorney-in-Fact 2004-06-03