X0201 42004-01-09 0000716054 CYPRESS BIOSCIENCE INC cypb 0001055666 KRANZLER JAY D 4350 EXECUTIVE DRIVE, SUITE 325 SAN DIEGO CA 92121 1100CEO and SecretaryCommon Stock2004-01-094M0231.4062A55750IBy TrustCommon Stock2004-01-094M0632272.50A118977IBy TrustCommon Stock2004-01-094M0145063.25A133483IBy TrustCommon Stock2004-01-094F0931615.71D124167IBy TrustCommon Stock2004-01-094F0374915.71D101944DCommon Stock79180IBy 401(k) PlanStock Option (right to buy)1.40622004-01-094M023D2001-03-202011-03-20Common Stock230DStock Option (right to buy)2.502004-01-094M063227D2000-01-272006-06-27Common Stock632271540DStock Option (right to buy)3.252004-01-094M014506D2002-04-292012-04-29Common Stock1450672260DThe shares subject to the option vest daily and ratably over a period of two years beginning March 20, 2001.The shares subject to the option vest daily and ratable over a period of four years beginning January 27, 2000.The shares subject to the option vest daily and ratable over a period of four years beginning April 29, 2002.Not ApplicableBetween July 1, 2003 and December 31, 2003, 2,333 shares of Common Stock were transferred to the Cypress Bioscience, Inc. 401(k) plan, of which the Reporting Person is the trustee and has voting power over such shares.Sabrina Martucci Johnson Attorney-in-Fact2004-01-13