X0201 42004-01-01 0000716054 CYPRESS BIOSCIENCE INC cypb 0001199112 NEMEROFF CHARLES B 4350 EXECUTIVE DRIVE, SUITE 325 SAN DIEGO CA 92121 1000Stock Option (right to buy)15.032004-01-014A013000A2014-01-01Common Stock1300013000DThe shares subject to the option shall vest daily and ratably over a period of one year beginning January 1, 2004, such that the option will be fully vested on January 1, 2005.Not ApplicableSabrina Martucci Johnson Attorney-in-Fact2004-01-13