X0201 42003-12-18 0000716054 CYPRESS BIOSCIENCE INC cypb 0001205698 VAUGHN JACK H 4350 EXECUTIVE DRIVE SUITE 325 SAN DIEGO CA 92121 1000Common Stock2003-12-184M075002.50A19625DCommon Stock2003-12-184M025002.51A22125DStock Option (Right to Buy)2.502003-12-184M01250D1995-06-262005-06-26Common Stock12500DStock Option (Right to Buy)2.502003-12-184M01250D1998-06-302006-06-27Common Stock12500DStock Option (Right to Buy)2.502003-12-184M01250D1997-10-152006-06-27Common Stock12500DStock Option (Right to Buy)2.502003-12-184M01250D1996-04-152006-04-15Common Stock12500DStock Option (Right to Buy)2.502003-12-184M01250D1999-09-142006-06-27Common Stock12500DStock Option (Right to Buy)2.502003-12-184M01250D2000-07-272006-06-27Common Stock12500DStock Option (Right to Buy)2.512003-12-184M02500D2003-03-272013-03-27Common Stock250061536DNot ApplicableTwenty-five thousand (25,000) of the shares subject to the option vested on March 27, 2003 with the remainder vesting thereafter on a daily basis over four years, such that all shares subject to the option will be fully vested and exercisable as of March 27, 2007.Sabrina Martucci Johnson Attorney-in-Fact2003-12-18