X0201 42003-08-11 0000716054 CYPRESS BIOSCIENCE INC cypb 0001055666 KRANZLER JAY D 4350 EXECUTIVE DRIVE, SUITE 325 SAN DIEGO CA 92121 1100Chief Executive Officer & Sec.Stock Option (right to buy)4.532003-08-114A05000004.53A2003-08-112013-08-11Common Stock500000500000DThe shares subject to the option vest daily and ratably over a period of four years beginning August 11, 2003.Sabrina Martucci Johnson Attorney-in-Fact2003-08-13