X0101 42003-07-22 0000716054 CYPRESS BIOSCIENCE INC cypb 0001205698 VAUGHN JACK A 1000Common Stock2003-07-224M0100002.51A14780DStock Option (Right to Buy)2.512003-07-224M0100000D2003-03-272013-03-27Common Stock1000064036DTwenty-five thousand (25,000) of the shares subject to the option vested on March 27, 2003 with the remainder vesting thereafter on a daily basis over four years, such that all shares subject to the option will be fully vested and exercisable as of March 27, 2007.Sabrina Martucci Johnson Attorney-in-Fact2003-07-23