The Prudential Series Fund

655 Broad Street, 17th Floor
Newark, New Jersey 07102

April 28, 2022

VIA EDGAR

U.S. Securities and Exchange Commission
100 F Street, N.E.
Washington, D.C. 20549-1520

Re:

497(j) Filing for The Prudential Series Fund
Registration numbers 002-80896 and 811-03623

Dear Sir or Madam:

Pursuant to Rule 497(j) under the Securities Act of 1933, as amended, please accept this certification that the Prospectus and Statement of Additional Information for the above-referenced Registrant do not differ from that contained in Post-Effective Amendment No. 92 to the Registrant’s Registration Statement on Form N-1A, which was electronically filed with the Commission on April 13, 2022.

Thank you for your attention to this filing. Please direct any questions regarding this filing to the undersigned at 973-716-6422.

Sincerely,

/s/ Patrick McGuinness

Patrick McGuinness
Assistant Secretary