CALCULATION OF REGISTRATION FEE

Title of Each Class of Securities Offered	Maximum Aggregate Offering Price	Amount of Registration Fee(1)(2)
4.100% InterNotes® Due April 15, 2020	$5,992,000	$695.67

(1)	Calculated in accordance with Rule 457(r) under the Securities Act of 1933.
(2)	The amount in this column has been transmitted to the SEC in connection with the securities offered by means of this pricing supplement.


Filed Under Rule 424(b)(3), Registration Statement No. 333-155631
Pricing Supplement Number 221 Dated 04/25/2011
(To: Prospectus Dated November 24, 2008 and Prospectus Supplement Dated: November 26, 2008)

CUSIP Number

Principal Amount

Selling Price

Gross Concession

Net Proceeds

Coupon Type

Coupon Rate

Coupon Frequency

Maturity Date

1st Coupon Date

1st Coupon Amount

Survivor's Option

Product Ranking

63743FMR4

$5,992,000.00

100.000%

1.650%

$5,893,132.00

FIXED

4.100%

SEMI-ANNUAL

04/15/2020

10/15/2011

$19.02

YES

Senior Unsecured Notes

Redemption Information: Non-Callable.

 
  National Rural Utilities Cooperative Finance Corp Offering Dates: April 25, 2011 through April 25, 2011
Trade Date: Monday, April 25, 2011 @12:00 PM ET
Settle Date: Thursday, April 28, 2011
Minimum Denomination/Increments: $1,000.00/$1,000.00
Initial trades settle flat and clear SDFS: DTC Book Entry only
DTC number: 0235 via RBC Dain Rauscher Inc. Agents: Banc of America Securities LLC, Incapital, LLC , Charles Schwab & Co., Inc., Comerica Securities, Edward D. Jones & Co., L.P., J.J.B. Hilliard, W.L. Lyons, Inc., Merrill Lynch & Co., Morgan Stanley, UBS Securities LLC If the maturity date or an interest payment date for any note is not a Business Day (as term is defined in Prospectus), principal, premium, if any, and interest for that note is paid on the next Business Day, and no interest will accrue from, and after, the maturity date or interest payment date. InterNotes® is a registered trademark of Incapital Holdings LLC. All rights reserved National Rural Utilities Cooperative Finance Corporation
InterNotes
Prospectus Dated 24-Nov-08 and Prospectus Supplement Dated: 26-Nov-08