Rule 424 (b) (3)
Registration No. 333-155631
CALCULATION OF REGISTRATION FEE
Title of Each Class of Securities Offered		Maximum Aggregate Offering Price		Amount of Registration Fee(1)(2)
Senior Debt Securities		$500,000.00		$19.65
(1)	Calculated in accordance with Rule 457(r) of the Securities Act of 1933.
(2)	Pursuant to Rule 457(p) under the Securities Act of 1933, unused filing fees of $16,249.21 have already been paid with respect to unsold securities that were previously registered pursuant to a Registration Statement on Form S-3 (No. 333-115248) filed by National Rural Utilities Cooperative Finance Corporation on May 6, 2004, and have been carried forward, of which $19.65 offset against the registration fee due for this offering and of which $16,229.56 remains available for future registration fees. No additional registration fee has been paid with respect to this offering.
TRADE DATE: December 29, 2008
PRICING SUPPLEMENT NO. 4572 DATED December 29, 2008
TO PROSPECTUS SUPPLEMENT DATED November 26, 2008
AND PROSPECTUS DATED November 24, 2008
NATIONAL RURAL UTILITES COOPERATIVE FINANCE CORPORATION
Medium-Term Notes, Series C
Due Nine Months or More from Date of Issuance
Principal Amount:			$500,000.00
Issue Price:			100% of Principal Amount
Original Issue Date:			01/02/2009
Maturity Date:			08/16/2010
Interest Rate:			4.70% per annum
Regular Record Dates:			Each January 1 and July 1
Interest Payment Dates:			Each January 15 and July 15
Redemption Date:			None
Agent's Commission:			None
Form of Note:			Certificated
(Book-Entry or Certificated)
Other Terms:			None
Medium-Term Notes, Series C, may be issued by National Rural Utilities Cooperative Finance Corporation in an unlimited aggregate principal amount.