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Note 14 - Commitments (Tables)
12 Months Ended
Dec. 31, 2015
Notes Tables  
Contractual Obligation, Fiscal Year Maturity Schedule [Table Text Block]
 
 
Contractual obligations
 
   
Operating
leases for lab
and office
space
   
Principal
payments on
credit facility
and exit fee
 
                 
2016
  266,100     900,000  
2017
    185,100       1,785,000  
Total
  $ 451,200     $ 2,685,000