X0306 4 2022-02-04 0000702325 FIRST MIDWEST BANCORP INC FMBI 0001471708 Sander Mark G 8750 WEST BRYN MAWR AVENUE SUITE 1300 CHICAGO IL 60631 1 1 President & COO Common Stock 2022-02-04 4 F 0 3838 20.88 D 249219 D Common Stock 2022-02-04 4 F 0 3925 20.88 D 245294 D Common Stock 399.9386 I Profit Sharing Plan Trust Reflects shares of the Issuer's common stock surrendered by the Reporting Person to satisfy tax withholding obligations upon the vesting of shares granted under a restricted stock award. Between January 26, 2021 and December 15, 2021, the Reporting Person acquired 11.0525 shares of First Midwest Bancorp, Inc. common stock pursuant to the Dividend Reinvestment feature of the First Midwest Bancorp, Inc. Savings and Profit Sharing Plan. The information in this report is based on plan statements dated April 13, 2021, July 13, 2021, October 12, 2021 and December 15, 2021. /s/ Andrea L. Stangl, Attorney-in-fact for Mark G. Sander 2022-02-08