<?xml version="1.0" encoding="us-ascii"?><InstanceReport xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><Version>2.2.0.25</Version><hasSegments>true</hasSegments><hasScenarios>false</hasScenarios><ReportLongName>0208 - Disclosure - Investments in Marketable Securities</ReportLongName><DisplayLabelColumn>true</DisplayLabelColumn><ShowElementNames>false</ShowElementNames><RoundingOption /><HasEmbeddedReports>false</HasEmbeddedReports><Columns><Column><Id>1</Id><IsAbstractGroupTitle>false</IsAbstractGroupTitle><LabelColumn>false</LabelColumn><CurrencyCode>USD</CurrencyCode><FootnoteIndexer /><hasSegments>false</hasSegments><hasScenarios>false</hasScenarios><MCU><KeyName>1/1/2011 - 3/31/2011
USD ($) / shares

USD ($)

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   &lt;!-- Begin Block Tagged Note 7 - us-gaap:MarketableSecuritiesTextBlock--&gt;
   &lt;div style="font-family: 'Times New Roman',Times,serif; margin-left: 0in; "&gt;
   &lt;div align="justify" style="font-size: 10pt; margin-top: 10pt"&gt;&lt;b&gt;7. Investments in Marketable Securities&lt;/b&gt;
   &lt;/div&gt;
   &lt;div align="justify" style="font-size: 10pt; margin-top: 10pt; text-indent: 4%"&gt;As of March&amp;#160;31, 2011, the Company held auction rate securities with a fair value of $45
   million ($69&amp;#160;million par value), which are classified as available-for-sale securities and
   noncurrent assets on the Company&amp;#8217;s condensed consolidated balance sheets. Contractual maturities
   for these auction rate securities range from 22 to 25&amp;#160;years. As a result of the liquidity issues
   experienced in the global credit and capital markets, all of the Company&amp;#8217;s auction rate securities
   have experienced failed auctions since August&amp;#160;2007. The estimated fair value of these auction rate
   securities no longer approximates par value. Refer to Note 8 for discussion on how the Company
   determines the fair value of its investments in auction rate securities.
   &lt;/div&gt;
   &lt;div align="justify" style="font-size: 10pt; margin-top: 10pt; text-indent: 4%"&gt;In the three months ended March&amp;#160;31, 2011, the Company sold certain investments in auction rate
   securities for proceeds of $12&amp;#160;million. Proceeds from the auction rate security sale transactions
   approximated the carrying amount of the investments.
   &lt;/div&gt;
   &lt;div align="justify" style="font-size: 10pt; margin-top: 10pt; text-indent: 4%"&gt;In the three months ended March&amp;#160;31, 2010, the Company sold certain investments in auction rate
   securities for proceeds of $132&amp;#160;million, resulting in $49&amp;#160;million of net realized gains recorded in
   nonoperating expense, net, of which $48&amp;#160;million represents the reclassification of prior period net
   unrealized gains from other comprehensive income as determined on a specific-identification basis.
   Additionally, in the first quarter of 2010, the Company recorded net unrealized losses of $1
   million in other comprehensive income related to the decline in fair value of certain investments
   in auction rate securities, which offset previously recognized unrealized gains.
   &lt;/div&gt;
   &lt;div align="justify" style="font-size: 10pt; margin-top: 10pt; text-indent: 4%"&gt;The Company continues to monitor the market for auction rate securities and consider its
   impact (if any) on the fair value of its remaining investments in these securities. If the current
   market conditions deteriorate, the Company may be required to record additional impairment charges
   in other nonoperating expense, net in future periods.
   &lt;/div&gt;
   &lt;!-- Folio --&gt;
   &lt;!-- /Folio --&gt;
   &lt;/div&gt;
   &lt;!-- PAGEBREAK --&gt;
   &lt;div style="font-family: 'Times New Roman',Times,serif; margin-left: 0in; "&gt;
   &lt;/div&gt;
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1/1/2011 - 3/31/2011
USD ($)
</KeyName><CurrencySymbol>$</CurrencySymbol><contextRef><ContextID>ThreeMonthsEnded_31Mar2011_Subsidiaries_Member</ContextID><EntitySchema>http://www.sec.gov/CIK</EntitySchema><EntityValue>0000701345</EntityValue><PeriodDisplayName /><PeriodType>duration</PeriodType><PeriodStartDate>2011-01-01T00:00:00</PeriodStartDate><PeriodEndDate>2011-03-31T00:00:00</PeriodEndDate><Segments><anyType xsi:type="Segment"><IsDefaultForEntity>false</IsDefaultForEntity><Name /><IsFromEntityGroup>false</IsFromEntityGroup><ValueName>US Airways, Inc. [Member]</ValueName><ValueType>dei_LegalEntityAxis</ValueType><Namespace>xbrldi</Namespace><Schema>http://xbrl.org/2006/xbrldi</Schema><DimensionInfo><Id>us-gaap_SubsidiariesMember</Id><dimensionId>dei_LegalEntityAxis</dimensionId><type>explicitMember</type></DimensionInfo></anyType></Segments><Scenarios /></contextRef><UPS><UnitProperty><UnitID>USD</UnitID><UnitType>Standard</UnitType><StandardMeasure><MeasureSchema>http://www.xbrl.org/2003/iso4217</MeasureSchema><MeasureValue>USD</MeasureValue><MeasureNamespace>iso4217</MeasureNamespace></StandardMeasure><Scale>0</Scale></UnitProperty></UPS><CurrencyCode>USD</CurrencyCode><OriginalCurrencyCode>USD</OriginalCurrencyCode></MCU><CurrencySymbol>$</CurrencySymbol><Labels><Label Id="1" Label="US Airways, Inc. [Member]" /><Label Id="2" Label="1/1/2011 - 3/31/2011" /></Labels></Columns></OriginalInstanceReportColumns><Unit>Other</Unit><ElementDataType /><SimpleDataType>na</SimpleDataType><ElementDefenition>No definition available.</ElementDefenition><ElementReferences>No authoritative reference available.</ElementReferences><IsTotalLabel>false</IsTotalLabel><IsEPS>false</IsEPS><Label>US Airways, Inc. [Member]</Label></Row><Row><Id>4</Id><IsAbstractGroupTitle>false</IsAbstractGroupTitle><Level>0</Level><ElementName>us-gaap_MarketableSecuritiesTextBlock</ElementName><ElementPrefix>us-gaap</ElementPrefix><IsBaseElement>true</IsBaseElement><BalanceType>na</BalanceType><PeriodType>duration</PeriodType><ShortDefinition>No definition available.</ShortDefinition><IsReportTitle>false</IsReportTitle><IsSegmentTitle>false</IsSegmentTitle><IsSubReportEnd>false</IsSubReportEnd><IsCalendarTitle>false</IsCalendarTitle><IsTuple>false</IsTuple><IsEquityPrevioslyReportedAsRow>false</IsEquityPrevioslyReportedAsRow><IsEquityAdjustmentRow>false</IsEquityAdjustmentRow><IsBeginningBalance>false</IsBeginningBalance><IsEndingBalance>false</IsEndingBalance><IsReverseSign>false</IsReverseSign><PreferredLabelRole>verboselabel</PreferredLabelRole><FootnoteIndexer /><Cells><Cell><Id>1</Id><IsNumeric>false</IsNumeric><IsRatio>false</IsRatio><DisplayZeroAsNone>false</DisplayZeroAsNone><NumericAmount>0</NumericAmount><RoundedNumericAmount>0</RoundedNumericAmount><NonNumbericText>&lt;!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --&gt;
   &lt;!-- Begin Block Tagged Note 18 - us-gaap:MarketableSecuritiesTextBlock--&gt;
   &lt;div style="font-family: 'Times New Roman',Times,serif; margin-left: 0in; "&gt;
   &lt;div align="justify" style="font-size: 10pt; margin-top: 10pt"&gt;&lt;b&gt;7. Investments in Marketable Securities&lt;/b&gt;
   &lt;/div&gt;
   &lt;div align="justify" style="font-size: 10pt; margin-top: 10pt; text-indent: 4%"&gt;As of March&amp;#160;31, 2011, US Airways held auction rate securities with a fair value of $45&amp;#160;million
   ($69&amp;#160;million par value), which are classified as available-for-sale securities and noncurrent
   assets on US Airways&amp;#8217; condensed consolidated balance sheets. Contractual maturities for these
   auction rate securities range from 22 to 25&amp;#160;years. As a result of the liquidity issues experienced
   in the global credit and capital markets, all of US Airways&amp;#8217; auction rate securities have
   experienced failed auctions since August&amp;#160;2007. The estimated fair value of these auction rate
   securities no longer approximates par value. Refer to Note 8 for discussion on how US Airways
   determines the fair value of its investments in auction rate securities.
   &lt;/div&gt;
   &lt;div align="justify" style="font-size: 10pt; margin-top: 10pt; text-indent: 4%"&gt;In the three months ended March&amp;#160;31, 2011, US Airways sold certain investments in auction rate
   securities for proceeds of $12&amp;#160;million. Proceeds from the auction rate security sale transactions
   approximated the carrying amount of the investments.
   &lt;/div&gt;
   &lt;div align="justify" style="font-size: 10pt; margin-top: 10pt; text-indent: 4%"&gt;In the three months ended March&amp;#160;31, 2010, US Airways sold certain investments in auction rate
   securities for proceeds of $132&amp;#160;million, resulting in $49&amp;#160;million of net realized gains recorded in
   nonoperating expense, net, of which $48&amp;#160;million represents the reclassification of prior period net
   unrealized gains from other comprehensive income as determined on a specific-identification basis.
   Additionally, in the first quarter of 2010, US Airways recorded net unrealized losses of $1&amp;#160;million
   in other comprehensive income related to the decline in fair value of certain investments in
   auction rate securities, which offset previously recognized unrealized gains.
   &lt;/div&gt;
   &lt;div align="justify" style="font-size: 10pt; margin-top: 10pt; text-indent: 4%"&gt;US Airways continues to monitor the market for auction rate securities and consider its impact
   (if any) on the fair value of its remaining investments in these securities. If the current market
   conditions deteriorate, US Airways may be required to record additional impairment charges in other
   nonoperating expense, net in future periods.
   &lt;/div&gt;
   &lt;!-- Folio --&gt;
   &lt;!-- /Folio --&gt;
   &lt;/div&gt;
   &lt;!-- PAGEBREAK --&gt;
   &lt;div style="font-family: 'Times New Roman',Times,serif; margin-left: 0in; "&gt;
   &lt;/div&gt;
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