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  <headerData>
    <submissionType>13F-NT</submissionType>
    <filerInfo>
      <liveTestFlag>LIVE</liveTestFlag>
      <flags>
        <confirmingCopyFlag>false</confirmingCopyFlag>
        <returnCopyFlag>true</returnCopyFlag>
        <overrideInternetFlag>false</overrideInternetFlag>
      </flags>
      <filer>
        <credentials>
          <cik>0000700733</cik>
          <ccc>XXXXXXXX</ccc>
        </credentials>
      </filer>
      <periodOfReport>09-30-2015</periodOfReport>
    </filerInfo>
  </headerData>
  <formData>
    <coverPage>
      <reportCalendarOrQuarter>09-30-2015</reportCalendarOrQuarter>
      <filingManager>
        <name>National Penn Bancshares Inc</name>
        <address>
          <ns1:street1>645 Hamilton Street, #1100</ns1:street1>
          <ns1:city>Allentown</ns1:city>
          <ns1:stateOrCountry>PA</ns1:stateOrCountry>
          <ns1:zipCode>18101</ns1:zipCode>
        </address>
      </filingManager>
      <reportType>13F NOTICE</reportType>
      <form13FFileNumber>028-17044</form13FFileNumber>
      <otherManagersInfo>
        <otherManager>
          <form13FFileNumber>028-05095</form13FFileNumber>
          <name>National Penn Investors Trust Co</name>
        </otherManager>
      </otherManagersInfo>
      <provideInfoForInstruction5>N</provideInfoForInstruction5>
    </coverPage>
    <signatureBlock>
      <name>Scott V. Fainor</name>
      <title>President and CEO</title>
      <phone>800-822-3321</phone>
      <signature>/s/ Scott V. Fainor</signature>
      <city>Allentown</city>
      <stateOrCountry>PA</stateOrCountry>
      <signatureDate>11-16-2015</signatureDate>
    </signatureBlock>
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