<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001510815</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000006951</issuerCik>
      <issuerName>APPLIED MATERIALS INC /DE</issuerName>
      <secFileNumber>000-06920</secFileNumber>
      <issuerAddress>
        <com:street1>3050 BOWERS AVE</com:street1>
        <com:city>SANTA CLARA</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>95054-3299</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>4085635300</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Nalamasu Omkaram</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>245 Summer Street</com:street1>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>21554</noOfUnitsSold>
      <aggregateMarketValue>4417492.30</aggregateMarketValue>
      <noOfUnitsOutstanding>796642427</noOfUnitsOutstanding>
      <approxSaleDate>09/30/2025</approxSaleDate>
      <securitiesExchangeName>nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/19/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Award </natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Applied Material </nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>19012</amountOfSecuritiesAcquired>
      <paymentDate>12/19/2021</paymentDate>
      <natureOfPayment>Compensation </natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/19/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Award	</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Applied Material	</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2231</amountOfSecuritiesAcquired>
      <paymentDate>12/19/2022</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/28/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Dividend reinvestment</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Applied Material	</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>57</amountOfSecuritiesAcquired>
      <paymentDate>02/28/2022</paymentDate>
      <natureOfPayment>n/a</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/12/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Dividend reinvestment	</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Applied Material	</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>97</amountOfSecuritiesAcquired>
      <paymentDate>03/12/2025</paymentDate>
      <natureOfPayment>n/a</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>06/11/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Dividend reinvestment	</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Applied Material	</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>97</amountOfSecuritiesAcquired>
      <paymentDate>06/11/2025</paymentDate>
      <natureOfPayment>n/a</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>09/10/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Dividend reinvestment	</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Applied Material	</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>61</amountOfSecuritiesAcquired>
      <paymentDate>09/10/2025</paymentDate>
      <natureOfPayment>n/a</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>shares are being sold from NANDINI PATEL TTEE SUKANYA NALAMASU IRRVOC TR U/A 12/17/24</remarks>
    <noticeSignature>
      <noticeDate>09/30/2025</noticeDate>
      <signature>/s/ Audrey Skillern as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for SUKANYA NALAMASU IRRV TR 12/17/24</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
