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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0000316011</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000059478</issuerCik>
      <issuerName>ELI LILLY &amp; Co</issuerName>
      <secFileNumber>001-06351</secFileNumber>
      <issuerAddress>
        <com:street1>LILLY CORPORATE CTR</com:street1>
        <com:street2>DROP CODE 1094</com:street2>
        <com:city>INDIANAPOLIS</com:city>
        <com:stateOrCountry>IN</com:stateOrCountry>
        <com:zipCode>46285</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>3172762000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>LILLY ENDOWMENT INC</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Capital Markets</name>
        <address>
          <com:street1>640 Fifth Avenue</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10019</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>220000</noOfUnitsSold>
      <aggregateMarketValue>89278200.00</aggregateMarketValue>
      <noOfUnitsOutstanding>949272933</noOfUnitsOutstanding>
      <approxSaleDate>05/02/2023</approxSaleDate>
      <securitiesExchangeName>NYSE, NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>02/10/1948</acquiredDate>
      <natureOfAcquisitionTransaction>Gift</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>J.K. Lilly Sr. Trust</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>Y</isGiftTransaction>
      <donarAcquiredDate>01/21/1937</donarAcquiredDate>
      <amountOfSecuritiesAcquired>38400000</amountOfSecuritiesAcquired>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lilly Endowment, Inc.</name>
        <address>
          <com:street1>2801 North Meridian Street</com:street1>
          <com:city>Indianapolis</com:city>
          <com:stateOrCountry>IN</com:stateOrCountry>
          <com:zipCode>46208-0068</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Eli Lilly and Company Common Stock</securitiesClassTitle>
      <saleDate>03/24/2023</saleDate>
      <amountOfSecuritiesSold>200000</amountOfSecuritiesSold>
      <grossProceeds>67164540.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lilly Endowment, Inc.</name>
        <address>
          <com:street1>2801 North Meridian Street</com:street1>
          <com:city>Indianapolis</com:city>
          <com:stateOrCountry>IN</com:stateOrCountry>
          <com:zipCode>46208-0068</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Eli Lilly and Company Common Stock</securitiesClassTitle>
      <saleDate>03/31/2023</saleDate>
      <amountOfSecuritiesSold>205000</amountOfSecuritiesSold>
      <grossProceeds>70111927.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lilly Endowment, Inc.</name>
        <address>
          <com:street1>2801 North Meridian Street</com:street1>
          <com:city>Indianapolis</com:city>
          <com:stateOrCountry>IN</com:stateOrCountry>
          <com:zipCode>46208-0068</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Eli Lilly and Company Common Stock</securitiesClassTitle>
      <saleDate>04/03/2023</saleDate>
      <amountOfSecuritiesSold>210000</amountOfSecuritiesSold>
      <grossProceeds>73603572.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lilly Endowment, Inc.</name>
        <address>
          <com:street1>2801 North Meridian Street</com:street1>
          <com:city>Indianapolis</com:city>
          <com:stateOrCountry>IN</com:stateOrCountry>
          <com:zipCode>46208-0068</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Eli Lilly and Company Common Stock</securitiesClassTitle>
      <saleDate>04/05/2023</saleDate>
      <amountOfSecuritiesSold>69703</amountOfSecuritiesSold>
      <grossProceeds>25327944.26</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lilly Endowment, Inc.</name>
        <address>
          <com:street1>2801 North Meridian Street</com:street1>
          <com:city>Indianapolis</com:city>
          <com:stateOrCountry>IN</com:stateOrCountry>
          <com:zipCode>46208-0068</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Eli Lilly and Company Common Stock</securitiesClassTitle>
      <saleDate>04/06/2023</saleDate>
      <amountOfSecuritiesSold>130297</amountOfSecuritiesSold>
      <grossProceeds>47853840.42</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lilly Endowment, Inc.</name>
        <address>
          <com:street1>2801 North Meridian Street</com:street1>
          <com:city>Indianapolis</com:city>
          <com:stateOrCountry>IN</com:stateOrCountry>
          <com:zipCode>46208-0068</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Eli Lilly and Company Common Stock</securitiesClassTitle>
      <saleDate>04/28/2023</saleDate>
      <amountOfSecuritiesSold>225000</amountOfSecuritiesSold>
      <grossProceeds>89657617.50</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>05/02/2023</noticeDate>
      <signature>/s/ Diane M. Stenson</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
