Income Taxes - Schedule of Reconciliation of Income Taxes (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Income Tax Disclosure [Abstract]
Income tax at the U.S. federal statutory tax rate	$ 2,662.9	$ 1,376.5	$ 1,429.3
Add (deduct):
Non-deductible acquired IPR&D	566.0	677.2	68.3
Foreign-derived intangible income deduction	(307.0)	(236.7)	(287.5)
International operations, including Puerto Rico	(302.1)	(187.1)	(299.5)
General business credits	(290.6)	(258.0)	(155.0)
Stock-based compensation	(184.7)	(79.9)	(48.9)
Valuation allowance release	(23.9)	(4.2)	(116.4)
Other	(30.2)	26.4	(28.7)
Income taxes	$ 2,090.4	$ 1,314.2	$ 561.6