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Asset Impairment, Restructuring, and Other Special Charges (Details) - USD ($)
$ in Millions
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Business Acquisition [Line Items]    
Severance $ (3.6) $ 7.3
Asset impairment and other special charges 427.5 49.5
Total asset impairment, restructuring, and other special charges 423.9 $ 56.8
Loxo Oncology, Inc.    
Business Acquisition [Line Items]    
Asset impairment and other special charges $ 400.7