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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 QKnNxOrVRlqcTIF70LpXDmMPMPleEyYhGE2hsW9qFMsD7oY5W50vqwk0vc2GbYg3
 jAqf+N9SPB11hlMgAcdgUA==

<SEC-DOCUMENT>0000005768-10-000024.txt : 20101101
<SEC-HEADER>0000005768-10-000024.hdr.sgml : 20101101
<ACCEPTANCE-DATETIME>20101101144749
ACCESSION NUMBER:		0000005768-10-000024
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20101029
FILED AS OF DATE:		20101101
DATE AS OF CHANGE:		20101101

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Callerame Joseph
		CENTRAL INDEX KEY:			0001293565

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-06549
		FILM NUMBER:		101154532

	MAIL ADDRESS:	
		STREET 1:		829 MIDDLESEX TURNPIKE
		CITY:			BILLERICA
		STATE:			MA
		ZIP:			01821

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AMERICAN SCIENCE & ENGINEERING, INC.
		CENTRAL INDEX KEY:			0000005768
		STANDARD INDUSTRIAL CLASSIFICATION:	X-RAY APPARATUS & TUBES & RELATED IRRADIATION APPARATUS [3844]
		IRS NUMBER:				042240991
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			0331

	BUSINESS ADDRESS:	
		STREET 1:		C/O AS&E
		STREET 2:		829 MIDDLESEX TURNPIKE
		CITY:			BILLERICA
		STATE:			MA
		ZIP:			01821
		BUSINESS PHONE:		9782628700

	MAIL ADDRESS:	
		STREET 1:		C/O AS&E
		STREET 2:		829 MIDDLESEX TURNPIKE
		CITY:			BILLERICA
		STATE:			MA
		ZIP:			01821

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AMERICAN SCIENCE & ENGINEERING INC
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-10-29</periodOfReport>

    <issuer>
        <issuerCik>0000005768</issuerCik>
        <issuerName>AMERICAN SCIENCE &amp; ENGINEERING, INC.</issuerName>
        <issuerTradingSymbol>ASEI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001293565</rptOwnerCik>
            <rptOwnerName>Callerame Joseph</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>AMERICAN SCIENCE AND ENGINEERING, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>829 MIDDLESEX TURNPIKE</rptOwnerStreet2>
            <rptOwnerCity>BILLERICA</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>01821</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>SVP</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2010-10-29</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>2000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>83.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>14877</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 13, 2010.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>M. Colette Cooke</signatureName>
        <signatureDate>2010-11-01</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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