The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1 800 FLOWERS COM INC CL A 68243Q106 1,048 37,947 SH   DFND 1 37,947 0 0
10X GENOMICS INC CL A COM 88025U109 74,213 410,018 SH   DFND 1 408,552 0 1,466
ABBOTT LABS COM 002824100 13,666 114,036 SH   DFND 1 38,943 0 75,093
ABBVIE INC COM 00287Y109 79,852 737,871 SH   DFND 1 723,294 0 14,577
ABCAM PLC ADS 000380204 8,409 437,539 SH   DFND 1 436,363 0 1,176
ACACIA RESH CORP ACACIA TCH COM 003881307 1,069 160,783 SH   DFND 1 160,783 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 60,263 1,054,655 SH   DFND 1 1,054,655 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 8,681 151,922 SH   OTR 2 151,922 0 0
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 4,603 16,661 SH   DFND 1 16,661 0 0
ACCOLADE INC COM 00437E102 30,931 681,748 SH   DFND 1 681,748 0 0
ACCOLADE INC COM 00437E102 4,538 100,020 SH   OTR 2 100,020 0 0
ACTIVISION BLIZZARD INC COM 00507V109 1,548 16,648 SH   DFND 1 16,648 0 0
ACV AUCTIONS INC COM CL A 00091G104 13,129 379,334 SH   DFND 1 379,334 0 0
ACV AUCTIONS INC COM CL A 00091G104 1,974 57,033 SH   OTR 2 57,033 0 0
ADECOAGRO S A COM L00849106 15,423 1,962,325 SH   DFND 1 1,962,325 0 0
ADECOAGRO S A COM L00849106 2,509 319,152 SH   OTR 2 319,152 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 3,024,606 6,362,635 SH   DFND 1 6,128,286 0 234,349
ADOBE SYSTEMS INCORPORATED COM 00724F101 35,292 74,241 SH   OTR 2 74,241 0 0
ADTALEM GLOBAL ED INC COM 00737L103 1,083 27,397 SH   DFND 1 27,397 0 0
ADVANCED DRAIN SYS INC DEL COM 00790R104 1,789 17,307 SH   DFND 1 17,307 0 0
ADVANCED MICRO DEVICES INC COM 007903107 3,554 45,272 SH   DFND 1 45,272 0 0
AES CORP COM 00130H105 89,786 3,348,983 SH   DFND 1 3,348,983 0 0
AES CORP UNIT 99/99/9999 00130H204 35,019 339,000 SH   DFND 1 339,000 0 0
AFFIRM HLDGS INC COM CL A 00827B106 171,983 2,431,891 SH   DFND 1 2,431,891 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 59,389 467,117 SH   DFND 1 464,443 0 2,674
AGNICO EAGLE MINES LTD COM 008474108 9,885 170,985 SH   DFND 1 170,884 0 101
AGORA INC ADS 00851L103 5,233 104,100 SH   DFND 1 104,100 0 0
AIRBNB INC COM CL A 009066101 585,484 3,115,276 SH   DFND 1 2,764,703 0 350,573
AIRBNB INC COM CL A 009066101 45,793 243,655 SH   OTR 2 243,655 0 0
ALCOA CORP COM 013872106 3,757 115,645 SH   DFND 1 115,593 0 52
ALCON AG ORD SHS H01301128 72,827 1,039,215 SH   DFND 1 1,038,983 0 232
ALCON AG ORD SHS H01301128 984 14,046 SH   OTR 2 14,046 0 0
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 23,259 141,562 SH   DFND 1 141,562 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 3,299 21,575 SH   DFND 1 21,575 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 280 1,234 SH   DFND 1 1,234 0 0
ALIGN TECHNOLOGY INC COM 016255101 83,371 153,955 SH   DFND 1 153,370 0 585
ALLAKOS INC COM 01671P100 12,774 111,292 SH   DFND 1 111,292 0 0
ALLEGHANY CORP DEL COM 017175100 16,786 26,803 SH   DFND 1 26,803 0 0
ALLIANT ENERGY CORP COM 018802108 102,124 1,885,598 SH   DFND 1 1,885,598 0 0
ALPHABET INC CAP STK CL A 02079K305 2,928,491 1,419,861 SH   DFND 1 1,375,619 0 44,242
ALPHABET INC CAP STK CL A 02079K305 34,698 16,823 SH   OTR 2 16,823 0 0
ALPHABET INC CAP STK CL C 02079K107 2,845,545 1,375,570 SH   DFND 1 1,301,078 0 74,492
ALPHABET INC CAP STK CL C 02079K107 34,538 16,696 SH   OTR 2 16,696 0 0
ALTICE USA INC CL A 02156K103 1,916 58,900 SH   DFND 1 58,900 0 0
AMAZON COM INC COM 023135106 8,345,851 2,697,361 SH   DFND 1 2,576,335 0 121,026
AMAZON COM INC COM 023135106 155,892 50,384 SH   OTR 2 50,384 0 0
AMEREN CORP COM 023608102 179,262 2,203,314 SH   DFND 1 2,203,314 0 0
AMERESCO INC CL A 02361E108 3,385 69,613 SH   DFND 1 69,574 0 39
AMERICAN CAMPUS CMNTYS INC COM 024835100 78,446 1,817,153 SH   DFND 1 1,817,153 0 0
AMERICAN ELEC PWR CO INC COM 025537101 68,123 804,281 SH   DFND 1 804,281 0 0
AMERICAN ELEC PWR CO INC UNIT 08/01/2021 025537127 7,343 152,152 SH   DFND 1 152,152 0 0
AMERICAN EXPRESS CO COM 025816109 822 5,810 SH   DFND 1 5,810 0 0
AMERICAN TOWER CORP NEW COM 03027X100 141,626 592,429 SH   DFND 1 453,559 0 138,870
AMERICAN WTR WKS CO INC NEW COM 030420103 86,732 578,520 SH   DFND 1 578,520 0 0
AMERIS BANCORP COM 03076K108 28,488 542,511 SH   DFND 1 542,511 0 0
AMERIS BANCORP COM 03076K108 3,817 72,700 SH   OTR 2 72,700 0 0
AMETEK INC COM 031100100 51,216 400,972 SH   DFND 1 398,578 0 2,394
AMGEN INC COM 031162100 1,432 5,754 SH   DFND 1 5,754 0 0
AMICUS THERAPEUTICS INC COM 03152W109 52,974 5,361,763 SH   DFND 1 5,361,763 0 0
AMICUS THERAPEUTICS INC COM 03152W109 3,673 371,716 SH   OTR 2 371,716 0 0
AMKOR TECHNOLOGY INC COM 031652100 2,064 87,048 SH   DFND 1 87,048 0 0
AMPHENOL CORP NEW CL A 032095101 60,492 916,959 SH   DFND 1 912,092 0 4,867
ANTERO MIDSTREAM CORP COM 03676B102 3,733 413,426 SH   DFND 1 413,426 0 0
AON PLC SHS CL A G0403H108 1,443 6,273 SH   DFND 1 6,273 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 112,632 2,624,833 SH   DFND 1 2,624,833 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 3,692 86,044 SH   OTR 2 86,044 0 0
APOLLO GLOBAL MGMT INC COM CL A 03768E105 37,227 791,904 SH   DFND 1 786,925 0 4,979
APPLE INC COM 037833100 6,643,213 54,385,702 SH   DFND 1 51,995,327 0 2,390,375
APPLE INC COM 037833100 133,575 1,093,531 SH   OTR 2 1,093,531 0 0
APTIV PLC SHS G6095L109 35,350 256,345 SH   DFND 1 254,879 0 1,466
ARBOR REALTY TRUST INC COM 038923108 1,511 95,033 SH   DFND 1 95,033 0 0
ARES MANAGEMENT CORPORATION CL A COM STK 03990B101 62,153 1,109,273 SH   DFND 1 1,104,880 0 4,393
ARGENX SE SPONSORED ADR 04016X101 197,045 715,513 SH   DFND 1 714,716 0 797
ARGENX SE SPONSORED ADR 04016X101 1,185 4,302 SH   OTR 2 4,302 0 0
ARRIVAL GROUP SHS L0423Q108 9,719 605,168 SH   DFND 1 601,353 0 3,815
ARTISAN PARTNERS ASSET MGMT CL A 04316A108 2,240 42,928 SH   DFND 1 42,928 0 0
ARVINAS INC COM 04335A105 10,816 163,635 SH   DFND 1 163,635 0 0
ASBURY AUTOMOTIVE GROUP INC COM 043436104 1,470 7,483 SH   DFND 1 7,483 0 0
ASGN INC COM 00191U102 22,451 235,244 SH   DFND 1 235,244 0 0
ASGN INC COM 00191U102 3,319 34,772 SH   OTR 2 34,772 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 26,371 42,716 SH   DFND 1 42,418 0 298
ASPEN TECHNOLOGY INC COM 045327103 1,469 10,176 SH   DFND 1 10,176 0 0
ASSETMARK FINL HLDGS INC COM 04546L106 11,472 491,505 SH   DFND 1 491,505 0 0
ASSETMARK FINL HLDGS INC COM 04546L106 1,667 71,423 SH   OTR 2 71,423 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 145,788 2,932,179 SH   DFND 1 2,932,179 0 0
ATKORE INC COM 047649108 1,893 26,323 SH   DFND 1 26,323 0 0
ATLANTIC UN BANKSHARES CORP COM 04911A107 10,815 281,929 SH   DFND 1 281,929 0 0
ATLANTIC UN BANKSHARES CORP COM 04911A107 2,981 77,720 SH   OTR 2 77,720 0 0
ATLASSIAN CORP PLC CL A G06242104 1,289,177 6,116,802 SH   DFND 1 5,864,052 0 252,750
ATLASSIAN CORP PLC CL A G06242104 31,069 147,414 SH   OTR 2 147,414 0 0
AVALARA INC COM 05338G106 35,061 262,764 SH   DFND 1 261,261 0 1,503
AVANGRID INC COM 05351W103 33,543 673,427 SH   DFND 1 673,427 0 0
AVANTOR INC COM 05352A100 98,002 3,387,562 SH   DFND 1 3,380,343 0 7,219
AVERY DENNISON CORP COM 053611109 4,056 22,085 SH   DFND 1 22,085 0 0
AVID BIOSERVICES INC COM 05368M106 3,192 175,115 SH   DFND 1 175,115 0 0
AVID BIOSERVICES INC COM 05368M106 865 47,449 SH   OTR 2 47,449 0 0
AVIENT CORPORATION COM 05368V106 74,018 1,565,835 SH   DFND 1 1,565,835 0 0
AVIENT CORPORATION COM 05368V106 10,089 213,444 SH   OTR 2 213,444 0 0
AXCELIS TECHNOLOGIES INC COM NEW 054540208 1,031 25,089 SH   DFND 1 25,089 0 0
AXIS CAP HLDGS LTD SHS G0692U109 33,797 681,815 SH   DFND 1 681,815 0 0
AXIS CAP HLDGS LTD SHS G0692U109 3,897 78,612 SH   OTR 2 78,612 0 0
AXOS FINANCIAL INC COM 05465C100 2,420 51,484 SH   DFND 1 51,484 0 0
AZEK CO INC CL A 05478C105 60,769 1,445,154 SH   DFND 1 1,438,844 0 6,310
AZEK CO INC CL A 05478C105 1,731 41,167 SH   OTR 2 41,167 0 0
BALLYS CORPORATION COM 05875B106 7,629 117,406 SH   DFND 1 117,406 0 0
BALLYS CORPORATION COM 05875B106 2,150 33,084 SH   OTR 2 33,084 0 0
BANDWIDTH INC COM CL A 05988J103 50,107 395,349 SH   DFND 1 395,349 0 0
BANDWIDTH INC COM CL A 05988J103 9,482 74,815 SH   OTR 2 74,815 0 0
BANKUNITED INC COM 06652K103 62,858 1,430,205 SH   DFND 1 1,430,205 0 0
BANKUNITED INC COM 06652K103 8,456 192,402 SH   OTR 2 192,402 0 0
BARRICK GOLD CORP COM 067901108 8,716 440,196 SH   DFND 1 439,925 0 271
BEAZER HOMES USA INC COM NEW 07556Q881 1,044 49,924 SH   DFND 1 49,924 0 0
BECTON DICKINSON & CO COM 075887109 66,560 273,742 SH   DFND 1 273,742 0 0
BEIGENE LTD SPONSORED ADR 07725L102 6,996 20,099 SH   DFND 1 20,099 0 0
BERKELEY LTS INC COM 084310101 2,096 41,720 SH   DFND 1 41,720 0 0
BHP GROUP LTD SPONSORED ADS 088606108 19,865 286,284 SH   DFND 1 286,115 0 169
BILIBILI INC SPONS ADS REP Z 090040106 112,379 1,049,678 SH   DFND 1 1,049,565 0 113
BILIBILI INC SPONS ADS REP Z 090040106 1,147 10,715 SH   OTR 2 10,715 0 0
BIO RAD LABS INC CL A 090572207 12,485 21,858 SH   DFND 1 21,803 0 55
BIOGEN INC CALL OPTIONS 09062X103 8,393 30,000 SH Call DFND 1 0 0 0
BIOGEN INC COM 09062X103 18,418 65,838 SH   DFND 1 65,838 0 0
BIOLIFE SOLUTIONS INC COM NEW 09062W204 9,114 253,162 SH   DFND 1 253,162 0 0
BIOLIFE SOLUTIONS INC COM NEW 09062W204 2,055 57,096 SH   OTR 2 57,096 0 0
BIONTECH SE PUT OPTIONS 09075V102 5,449 49,900 SH Put DFND 1 49,900 0 0
BIONTECH SE SPONSORED ADS 09075V102 32,599 298,555 SH   DFND 1 298,555 0 0
BJS RESTAURANTS INC COM 09180C106 5,449 93,815 SH   DFND 1 93,815 0 0
BJS RESTAURANTS INC COM 09180C106 878 15,123 SH   OTR 2 15,123 0 0
BJS WHSL CLUB HLDGS INC COM 05550J101 53,573 1,194,239 SH   DFND 1 1,194,239 0 0
BJS WHSL CLUB HLDGS INC COM 05550J101 6,473 144,286 SH   OTR 2 144,286 0 0
BK OF AMERICA CORP COM 060505104 195,367 5,049,538 SH   DFND 1 4,986,827 0 62,711
BLACKLINE INC COM 09239B109 1,304 12,028 SH   DFND 1 12,028 0 0
BLACKSTONE GROUP INC COM 09260D107 77,636 1,041,681 SH   DFND 1 1,041,681 0 0
BLOOMIN BRANDS INC COM 094235108 44,918 1,660,532 SH   DFND 1 1,660,532 0 0
BLOOMIN BRANDS INC COM 094235108 6,559 242,490 SH   OTR 2 242,490 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 40,148 412,913 SH   DFND 1 412,913 0 0
BOISE CASCADE CO DEL COM 09739D100 1,935 32,342 SH   DFND 1 32,342 0 0
BOOT BARN HLDGS INC COM 099406100 30,477 489,120 SH   DFND 1 489,120 0 0
BOOT BARN HLDGS INC COM 099406100 4,886 78,414 SH   OTR 2 78,414 0 0
BOSTON SCIENTIFIC CORP COM 101137107 30,960 801,037 SH   DFND 1 801,037 0 0
BRIGHTSPHERE INVT GROUP INC COM 10948W103 70,914 3,479,577 SH   DFND 1 3,479,577 0 0
BRIGHTSPHERE INVT GROUP INC COM 10948W103 8,501 417,136 SH   OTR 2 417,136 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 94,411 1,495,502 SH   DFND 1 1,495,502 0 0
BROADCOM INC COM 11135F101 148,113 319,443 SH   DFND 1 316,073 0 3,370
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 1,599 10,442 SH   DFND 1 10,442 0 0
BROOKDALE SR LIVING INC COM 112463104 1,343 222,016 SH   DFND 1 222,016 0 0
BROOKFIELD RENEWABLE CORP CL A SUB VTG 11284V105 2,822 60,305 SH   DFND 1 60,305 0 0
BROOKLINE BANCORP INC DEL COM 11373M107 19,069 1,271,288 SH   DFND 1 1,271,288 0 0
BROOKLINE BANCORP INC DEL COM 11373M107 5,381 358,741 SH   OTR 2 358,741 0 0
BROOKS AUTOMATION INC NEW COM 114340102 64,546 790,519 SH   DFND 1 790,519 0 0
BROOKS AUTOMATION INC NEW COM 114340102 9,090 111,326 SH   OTR 2 111,326 0 0
BRUNSWICK CORP COM 117043109 92,542 970,340 SH   DFND 1 970,340 0 0
BRUNSWICK CORP COM 117043109 10,808 113,330 SH   OTR 2 113,330 0 0
BUCKLE INC COM 118440106 1,674 42,610 SH   DFND 1 42,610 0 0
BUMBLE INC COM CL A 12047B105 96,687 1,549,972 SH   DFND 1 1,549,972 0 0
BUNGE LIMITED COM G16962105 8,939 112,766 SH   DFND 1 112,704 0 62
BURLINGTON STORES INC COM 122017106 79,815 267,117 SH   DFND 1 265,875 0 1,242
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 52,119 1,936,078 SH   DFND 1 1,936,078 0 0
BYLINE BANCORP INC COM 124411109 15,485 732,116 SH   DFND 1 732,116 0 0
BYLINE BANCORP INC COM 124411109 3,787 179,066 SH   OTR 2 179,066 0 0
C H ROBINSON WORLDWIDE INC COM NEW 12541W209 4,291 44,964 SH   DFND 1 44,964 0 0
C4 THERAPEUTICS INC COM STK 12529R107 16,480 445,511 SH   DFND 1 445,511 0 0
C4 THERAPEUTICS INC COM STK 12529R107 1,688 45,637 SH   OTR 2 45,637 0 0
CABOT OIL & GAS CORP COM 127097103 5,827 310,301 SH   DFND 1 310,119 0 182
CACTUS INC CL A 127203107 21,287 695,218 SH   DFND 1 695,131 0 87
CACTUS INC CL A 127203107 3,688 120,438 SH   OTR 2 120,438 0 0
CADENCE DESIGN SYSTEM INC COM 127387108 2,727 19,910 SH   DFND 1 19,910 0 0
CAMPING WORLD HLDGS INC CL A 13462K109 1,065 29,279 SH   DFND 1 29,279 0 0
CANADIAN NATL RY CO COM 136375102 5,142 44,295 SH   DFND 1 44,295 0 0
CANNAE HLDGS INC COM 13765N107 1,140 28,783 SH   DFND 1 28,783 0 0
CAPITAL ONE FINL CORP COM 14040H105 125,802 988,778 SH   DFND 1 988,778 0 0
CARDLYTICS INC COM 14161W105 29,426 268,234 SH   DFND 1 268,234 0 0
CARDLYTICS INC COM 14161W105 4,984 45,437 SH   OTR 2 45,437 0 0
CARVANA CO CL A 146869102 1,322,146 5,038,668 SH   DFND 1 4,848,481 0 190,187
CARVANA CO CL A 146869102 18,986 72,355 SH   OTR 2 72,355 0 0
CATALENT INC COM 148806102 46,004 436,841 SH   DFND 1 434,849 0 1,992
CATERPILLAR INC COM 149123101 14,521 62,625 SH   DFND 1 62,625 0 0
CBIZ INC COM 124805102 1,117 34,214 SH   DFND 1 34,214 0 0
CBRE GROUP INC CL A 12504L109 24,504 309,741 SH   DFND 1 307,945 0 1,796
CDK GLOBAL INC COM 12508E101 4,489 83,035 SH   DFND 1 83,035 0 0
CENTERPOINT ENERGY INC COM 15189T107 97,547 4,306,717 SH   DFND 1 4,306,717 0 0
CENTURY CMNTYS INC COM 156504300 31,153 516,455 SH   DFND 1 516,455 0 0
CENTURY CMNTYS INC COM 156504300 4,564 75,667 SH   OTR 2 75,667 0 0
CERTARA INC COM 15687V109 2,085 76,388 SH   DFND 1 76,388 0 0
CHAMPIONX CORPORATION COM 15872M104 1,243 57,225 SH   DFND 1 57,225 0 0
CHANGE HEALTHCARE INC COM 15912K100 9,793 443,128 SH   DFND 1 443,128 0 0
CHANNELADVISOR CORP COM 159179100 1,154 48,986 SH   DFND 1 48,986 0 0
CHART INDS INC COM 16115Q308 18,572 130,464 SH   DFND 1 130,389 0 75
CHENIERE ENERGY INC COM NEW 16411R208 149,843 2,080,866 SH   DFND 1 2,080,751 0 115
CHEVRON CORP NEW COM 166764100 92,294 880,750 SH   DFND 1 864,771 0 15,979
CHEWY INC CL A 16679L109 244,211 2,882,906 SH   DFND 1 2,564,048 0 318,858
CHIPOTLE MEXICAN GRILL INC COM 169656105 1,077,581 758,422 SH   DFND 1 716,836 0 41,586
CHIPOTLE MEXICAN GRILL INC COM 169656105 16,094 11,327 SH   OTR 2 11,327 0 0
CHUBB LIMITED COM H1467J104 176,885 1,119,738 SH   DFND 1 1,119,738 0 0
CIGNA CORP NEW COM 125523100 152,878 632,406 SH   DFND 1 632,406 0 0
CIMAREX ENERGY CO COM 171798101 10,197 171,697 SH   DFND 1 171,592 0 105
CINTAS CORP COM 172908105 1,759 5,153 SH   DFND 1 5,153 0 0
CISCO SYS INC COM 17275R102 83,135 1,607,716 SH   DFND 1 1,572,867 0 34,849
CITI TRENDS INC COM 17306X102 3,358 40,078 SH   DFND 1 40,078 0 0
CITI TRENDS INC COM 17306X102 893 10,660 SH   OTR 2 10,660 0 0
CITIGROUP INC COM NEW 172967424 125,792 1,729,098 SH   DFND 1 1,729,098 0 0
CLEARWATER PAPER CORP COM 18538R103 1,477 39,267 SH   DFND 1 39,267 0 0
CLEARWAY ENERGY INC CL C 18539C204 3,005 106,772 SH   DFND 1 106,772 0 0
CMS ENERGY CORP COM 125896100 124,682 2,036,629 SH   DFND 1 2,036,629 0 0
CNO FINL GROUP INC COM 12621E103 2,504 103,095 SH   DFND 1 103,095 0 0
COGNEX CORP COM 192422103 65,545 789,788 SH   DFND 1 786,410 0 3,378
COLFAX CORP COM 194014106 61,301 1,399,229 SH   DFND 1 1,399,229 0 0
COLFAX CORP COM 194014106 8,271 188,803 SH   OTR 2 188,803 0 0
COMCAST CORP NEW CL A 20030N101 33,585 620,672 SH   DFND 1 582,936 0 37,736
COMMUNITY HEALTH SYS INC NEW COM 203668108 1,429 105,686 SH   DFND 1 105,686 0 0
CONCRETE PUMPING HLDGS INC COM 206704108 2,745 370,478 SH   DFND 1 370,478 0 0
CONCRETE PUMPING HLDGS INC COM 206704108 782 105,480 SH   OTR 2 105,480 0 0
CONOCOPHILLIPS COM 20825C104 281,154 5,307,791 SH   DFND 1 5,307,487 0 304
CONSTELLATION PHARMCETICLS I COM 210373106 24,384 1,042,486 SH   DFND 1 1,042,486 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 2,240 95,774 SH   OTR 2 95,774 0 0
CONSTELLIUM SE CL A SHS F21107101 10,445 710,550 SH   DFND 1 710,085 0 465
COOPER COS INC COM NEW 216648402 108,841 283,373 SH   DFND 1 282,677 0 696
CORNING INC COM 219350105 17,438 400,773 SH   DFND 1 400,773 0 0
COSTAR GROUP INC COM 22160N109 27,736 33,747 SH   DFND 1 33,376 0 371
COSTCO WHSL CORP NEW COM 22160K105 1,288,333 3,655,054 SH   DFND 1 3,497,325 0 157,729
COSTCO WHSL CORP NEW COM 22160K105 17,027 48,306 SH   OTR 2 48,306 0 0
COUPA SOFTWARE INC COM 22266L106 597,395 2,347,511 SH   DFND 1 2,246,147 0 101,364
COUPA SOFTWARE INC COM 22266L106 7,781 30,576 SH   OTR 2 30,576 0 0
COUSINS PPTYS INC COM NEW 222795502 38,065 1,076,790 SH   DFND 1 1,076,790 0 0
COUSINS PPTYS INC COM NEW 222795502 4,551 128,747 SH   OTR 2 128,747 0 0
COVETRUS INC COM 22304C100 16,817 561,109 SH   DFND 1 561,109 0 0
COVETRUS INC COM 22304C100 4,144 138,279 SH   OTR 2 138,279 0 0
CRESCENT ACQUISITION CORP COM CL A 22564L105 10,762 1,069,804 SH   DFND 1 1,069,804 0 0
CRESCENT ACQUISITION CORP COM CL A 22564L105 3,017 299,901 SH   OTR 2 299,901 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 33,534 275,211 SH   DFND 1 275,211 0 0
CROCS INC COM 227046109 938 11,661 SH   DFND 1 11,661 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 1,083,292 5,935,526 SH   DFND 1 5,811,924 0 123,602
CROWDSTRIKE HLDGS INC CL A 22788C105 13,873 76,010 SH   OTR 2 76,010 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 2,548 14,803 SH   DFND 1 14,803 0 0
CROWN HLDGS INC COM 228368106 152,296 1,569,418 SH   DFND 1 1,566,795 0 2,623
CURTISS WRIGHT CORP COM 231561101 18,643 157,196 SH   DFND 1 157,196 0 0
CURTISS WRIGHT CORP COM 231561101 2,602 21,937 SH   OTR 2 21,937 0 0
CYBERARK SOFTWARE LTD SHS M2682V108 1,087 8,401 SH   DFND 1 8,401 0 0
D R HORTON INC COM 23331A109 88,597 994,128 SH   DFND 1 994,128 0 0
DANAHER CORPORATION COM 235851102 1,178,546 5,236,120 SH   DFND 1 4,968,675 0 267,445
DANAHER CORPORATION COM 235851102 13,697 60,854 SH   OTR 2 60,854 0 0
DARDEN RESTAURANTS INC COM 237194105 2,139 15,066 SH   DFND 1 15,066 0 0
DARLING INGREDIENTS INC COM 237266101 39,929 542,661 SH   DFND 1 542,536 0 125
DAVITA INC COM 23918K108 1,624 15,072 SH   DFND 1 15,072 0 0
DCP MIDSTREAM LP COM UT LTD PTN 23311P100 20,247 934,753 SH   DFND 1 934,753 0 0
DEERE & CO COM 244199105 76,935 205,631 SH   DFND 1 205,631 0 0
DELTA AIR LINES INC DEL COM NEW 247361702 66,143 1,369,987 SH   DFND 1 1,369,987 0 0
DENALI THERAPEUTICS INC COM 24823R105 21,385 374,512 SH   DFND 1 374,512 0 0
DESCARTES SYS GROUP INC COM 249906108 14,077 231,109 SH   DFND 1 231,109 0 0
DESCARTES SYS GROUP INC COM 249906108 1,869 30,680 SH   OTR 2 30,680 0 0
DEVON ENERGY CORP NEW COM 25179M103 55,725 2,550,362 SH   DFND 1 2,549,890 0 472
DEXCOM INC COM 252131107 603,014 1,677,881 SH   DFND 1 1,570,771 0 107,110
DEXCOM INC COM 252131107 8,267 23,003 SH   OTR 2 23,003 0 0
DIAGEO PLC SPON ADR NEW 25243Q205 398 2,421 SH   DFND 1 2,421 0 0
DIAMONDBACK ENERGY INC COM 25278X109 20,070 273,097 SH   DFND 1 272,937 0 160
DIAMONDROCK HOSPITALITY CO COM 252784301 1,307 126,914 SH   DFND 1 126,914 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 10,575 413,565 SH   DFND 1 413,565 0 0
DIGITAL TURBINE INC COM NEW 25400W102 1,455 18,108 SH   DFND 1 18,108 0 0
DISNEY WALT CO COM 254687106 177,217 960,424 SH   DFND 1 945,439 0 14,985
DOCUSIGN INC COM 256163106 364,695 1,801,408 SH   DFND 1 1,587,700 0 213,708
DOCUSIGN INC COM 256163106 32,958 162,794 SH   OTR 2 162,794 0 0
DOLLAR GEN CORP NEW COM 256677105 2,282 11,262 SH   DFND 1 11,262 0 0
DOLLAR TREE INC COM 256746108 1,687 14,737 SH   DFND 1 14,737 0 0
DOMINION ENERGY INC COM 25746U109 361,198 4,755,113 SH   DFND 1 4,755,113 0 0
DOVER CORP COM 260003108 972 7,091 SH   DFND 1 7,091 0 0
DOW INC COM 260557103 84,345 1,319,123 SH   DFND 1 1,319,072 0 51
DTE ENERGY CO COM 233331107 115,556 867,929 SH   DFND 1 867,929 0 0
DUKE ENERGY CORP NEW COM NEW 26441C204 54,085 560,297 SH   DFND 1 560,297 0 0
DYNATRACE INC COM NEW 268150109 405,741 8,410,879 SH   DFND 1 7,407,394 0 1,003,485
DYNATRACE INC COM NEW 268150109 36,946 765,881 SH   OTR 2 765,881 0 0
E L F BEAUTY INC COM 26856L103 24,694 920,359 SH   DFND 1 920,359 0 0
E L F BEAUTY INC COM 26856L103 6,521 243,062 SH   OTR 2 243,062 0 0
EAST WEST BANCORP INC COM 27579R104 29,282 396,780 SH   DFND 1 396,780 0 0
EASTERN BANKSHARES INC COM 27627N105 24,446 1,267,310 SH   DFND 1 1,267,310 0 0
EASTERN BANKSHARES INC COM 27627N105 2,975 154,218 SH   OTR 2 154,218 0 0
EBAY INC. COM 278642103 5,652 92,297 SH   DFND 1 92,297 0 0
EDISON INTL COM 281020107 72,888 1,243,814 SH   DFND 1 1,243,814 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 44,330 530,008 SH   DFND 1 530,008 0 0
EMERGENT BIOSOLUTIONS INC COM 29089Q105 12,357 132,990 SH   DFND 1 132,990 0 0
EMERGENT BIOSOLUTIONS INC COM 29089Q105 2,746 29,560 SH   OTR 2 29,560 0 0
EMERSON ELEC CO COM 291011104 44,464 492,836 SH   DFND 1 492,836 0 0
ENBRIDGE INC COM 29250N105 86,820 2,382,348 SH   DFND 1 2,382,348 0 0
ENERGY TRANSFER LP COM UT LTD PTN 29273V100 24,196 3,150,540 SH   DFND 1 3,150,540 0 0
ENERPAC TOOL GROUP CORP CL A COM 292765104 18,014 689,641 SH   DFND 1 689,641 0 0
ENERPAC TOOL GROUP CORP CL A COM 292765104 3,599 137,800 SH   OTR 2 137,800 0 0
ENPHASE ENERGY INC COM 29355A107 43,521 268,382 SH   DFND 1 267,032 0 1,350
ENSIGN GROUP INC COM 29358P101 1,419 15,126 SH   DFND 1 15,126 0 0
ENTEGRIS INC COM 29362U104 32,552 291,161 SH   DFND 1 290,170 0 991
ENTERGY CORP NEW COM 29364G103 70,564 709,399 SH   DFND 1 709,399 0 0
ENTERPRISE FINL SVCS CORP COM 293712105 27,496 556,146 SH   DFND 1 556,146 0 0
ENTERPRISE FINL SVCS CORP COM 293712105 5,275 106,698 SH   OTR 2 106,698 0 0
ENTERPRISE PRODS PARTNERS L COM 293792107 21,920 995,445 SH   DFND 1 995,445 0 0
EQT CORP COM 26884L109 5,191 279,395 SH   DFND 1 279,227 0 168
EQUINIX INC COM 29444U700 67,735 99,670 SH   DFND 1 99,670 0 0
EQUITRANS MIDSTREAM CORP COM 294600101 12,340 1,512,248 SH   DFND 1 1,512,248 0 0
ESSENTIAL UTILS INC COM 29670G102 98,656 2,204,614 SH   DFND 1 2,204,614 0 0
ETSY INC COM 29786A106 38,016 188,507 SH   DFND 1 187,355 0 1,152
EVERBRIDGE INC COM 29978A104 51,718 426,786 SH   DFND 1 426,786 0 0
EVERBRIDGE INC COM 29978A104 7,178 59,236 SH   OTR 2 59,236 0 0
EVERGY INC COM 30034W106 71,614 1,202,986 SH   DFND 1 1,202,986 0 0
EVERSOURCE ENERGY COM 30040W108 57,746 666,892 SH   DFND 1 666,892 0 0
EVO PMTS INC CL A COM 26927E104 34,066 1,237,855 SH   DFND 1 1,237,855 0 0
EVO PMTS INC CL A COM 26927E104 7,224 262,506 SH   OTR 2 262,506 0 0
EVOQUA WATER TECHNOLOGIES CO COM 30057T105 1,363 51,841 SH   DFND 1 51,841 0 0
EXACT SCIENCES CORP COM 30063P105 29,268 222,094 SH   DFND 1 220,885 0 1,209
EXXON MOBIL CORP COM 30231G102 4,013 71,872 SH   DFND 1 36,927 0 34,945
FACEBOOK INC CL A 30303M102 4,333,080 14,711,847 SH   DFND 1 14,085,000 0 626,847
FACEBOOK INC CL A 30303M102 55,327 187,847 SH   OTR 2 187,847 0 0
FARFETCH LTD ORD SH CL A 30744W107 729,030 13,750,078 SH   DFND 1 13,214,131 0 535,947
FARFETCH LTD ORD SH CL A 30744W107 22,387 422,244 SH   OTR 2 422,244 0 0
FATE THERAPEUTICS INC COM 31189P102 61,342 743,992 SH   DFND 1 743,992 0 0
FEDEX CORP COM 31428X106 80,254 282,544 SH   DFND 1 282,544 0 0
FERRARI N V COM N3167Y103 39,668 189,547 SH   DFND 1 187,798 0 1,749
FIRST BANCORP N C COM 318910106 24,633 566,261 SH   DFND 1 566,261 0 0
FIRST BANCORP N C COM 318910106 5,632 129,480 SH   OTR 2 129,480 0 0
FIRST FNDTN INC COM 32026V104 19,815 844,626 SH   DFND 1 844,626 0 0
FIRST FNDTN INC COM 32026V104 4,330 184,579 SH   OTR 2 184,579 0 0
FIRSTENERGY CORP COM 337932107 608 17,531 SH   DFND 1 17,531 0 0
FIRSTSERVICE CORP NEW COM 33767E202 425 2,863 SH   DFND 1 2,863 0 0
FIVE BELOW INC COM 33829M101 75,570 396,089 SH   DFND 1 394,573 0 1,516
FIVE BELOW INC COM 33829M101 1,983 10,393 SH   OTR 2 10,393 0 0
FIVE9 INC COM 338307101 53,141 339,929 SH   DFND 1 337,838 0 2,091
FLUIDIGM CORP DEL COM 34385P108 775 171,460 SH   DFND 1 171,460 0 0
FMC CORP COM NEW 302491303 89,729 811,220 SH   DFND 1 811,192 0 28
FOCUS FINL PARTNERS INC COM CL A 34417P100 48,275 1,159,899 SH   DFND 1 1,159,899 0 0
FOCUS FINL PARTNERS INC COM CL A 34417P100 6,482 155,737 SH   OTR 2 155,737 0 0
FORMFACTOR INC COM 346375108 1,112 24,647 SH   DFND 1 24,647 0 0
FORTIVE CORP COM 34959J108 63,503 898,973 SH   DFND 1 898,973 0 0
FREEPORT-MCMORAN INC CL B 35671D857 26,068 791,613 SH   DFND 1 791,162 0 451
FRESHPET INC COM 358039105 81,457 512,920 SH   DFND 1 511,107 0 1,813
FRESHPET INC COM 358039105 6,648 41,862 SH   OTR 2 41,862 0 0
FTAC OLYMPUS ACQUISITION COR CL A SHS G37288100 5,932 561,243 SH   DFND 1 561,243 0 0
FTAC OLYMPUS ACQUISITION COR CL A SHS G37288100 1,676 158,531 SH   OTR 2 158,531 0 0
FULLER H B CO COM 359694106 1,099 17,463 SH   DFND 1 17,463 0 0
FULTON FINL CORP PA COM 360271100 1,271 74,604 SH   DFND 1 74,604 0 0
GAMING & LEISURE PPTYS INC COM 36467J108 30,235 712,588 SH   DFND 1 712,588 0 0
GENERAC HLDGS INC COM 368736104 3,397 10,373 SH   DFND 1 10,373 0 0
GENERAL ELECTRIC CO COM 369604103 75,997 5,788,016 SH   DFND 1 5,788,016 0 0
GENERAL MTRS CO COM 37045V100 205,874 3,582,906 SH   DFND 1 3,582,906 0 0
GENETRON HLDGS LTD ADS 37186H100 42,790 1,993,946 SH   DFND 1 1,993,946 0 0
GFL ENVIRONMENTAL INC SUB VTG SHS 36168Q104 49,457 1,415,071 SH   DFND 1 1,408,876 0 6,195
GFL ENVIRONMENTAL INC UNIT 99/99/9999T 36168Q120 33,423 409,743 SH   DFND 1 409,743 0 0
GILEAD SCIENCES INC COM 375558103 34,907 540,103 SH   DFND 1 540,103 0 0
GLACIER BANCORP INC NEW COM 37637Q105 1,234 21,613 SH   DFND 1 21,613 0 0
GLOBANT S A COM L44385109 85,792 413,235 SH   DFND 1 411,840 0 1,395
GLOBANT S A COM L44385109 2,267 10,921 SH   OTR 2 10,921 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 663,206 2,028,154 SH   DFND 1 1,906,163 0 121,991
GOLDMAN SACHS GROUP INC COM 38141G104 6,835 20,901 SH   OTR 2 20,901 0 0
GOOSEHEAD INS INC COM CL A 38267D109 18,656 174,055 SH   DFND 1 174,055 0 0
GOOSEHEAD INS INC COM CL A 38267D109 4,578 42,716 SH   OTR 2 42,716 0 0
GRAY TELEVISION INC COM 389375106 1,309 71,115 SH   DFND 1 71,115 0 0
GREAT LAKES DREDGE & DOCK CO COM 390607109 68,569 4,702,997 SH   DFND 1 4,702,997 0 0
GREAT LAKES DREDGE & DOCK CO COM 390607109 8,929 612,390 SH   OTR 2 612,390 0 0
GREAT WESTN NATL BK PORTLAND COM 695263103 25,363 664,824 SH   DFND 1 664,824 0 0
GREAT WESTN NATL BK PORTLAND COM 695263103 3,154 82,672 SH   OTR 2 82,672 0 0
GRID DYNAMICS HLDGS INC CL A 39813G109 9,255 580,965 SH   DFND 1 580,965 0 0
GRID DYNAMICS HLDGS INC CL A 39813G109 2,624 164,715 SH   OTR 2 164,715 0 0
GRIFFON CORP COM 398433102 1,517 55,818 SH   DFND 1 55,818 0 0
GUARDANT HEALTH INC COM 40131M109 411,929 2,698,515 SH   DFND 1 2,608,032 0 90,483
GUARDANT HEALTH INC COM 40131M109 4,603 30,156 SH   OTR 2 30,156 0 0
HALLIBURTON CO COM 406216101 8,244 384,176 SH   DFND 1 383,975 0 201
HAMILTON LANE INC CL A 407497106 15,645 176,661 SH   DFND 1 176,661 0 0
HAMILTON LANE INC CL A 407497106 4,327 48,855 SH   OTR 2 48,855 0 0
HANNON ARMSTRONG SUST INFR C COM 41068X100 6,214 110,772 SH   DFND 1 110,709 0 63
HARSCO CORP COM 415864107 36,955 2,154,783 SH   DFND 1 2,154,783 0 0
HARSCO CORP COM 415864107 5,309 309,579 SH   OTR 2 309,579 0 0
HAWAIIAN HOLDINGS INC COM 419879101 1,487 55,743 SH   DFND 1 55,743 0 0
HCA HEALTHCARE INC COM 40412C101 5,343 28,370 SH   DFND 1 28,370 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 24,562 316,148 SH   DFND 1 316,148 0 0
HEALTHEQUITY INC COM 42226A107 11,735 172,568 SH   DFND 1 172,568 0 0
HEALTHEQUITY INC COM 42226A107 2,965 43,603 SH   OTR 2 43,603 0 0
HENRY JACK & ASSOC INC COM 426281101 15,176 100,024 SH   DFND 1 99,446 0 578
HERBALIFE NUTRITION LTD COM SHS G4412G101 4,256 95,945 SH   DFND 1 95,945 0 0
HERC HLDGS INC COM 42704L104 2,482 24,491 SH   DFND 1 24,491 0 0
HERSHEY CO COM 427866108 1,366 8,635 SH   DFND 1 8,635 0 0
HESS CORP COM 42809H107 21,798 308,061 SH   DFND 1 307,889 0 172
HESS MIDSTREAM LP CL A SHS 428103105 3,695 164,799 SH   DFND 1 164,799 0 0
HILL ROM HLDGS INC COM 431475102 19,386 175,472 SH   DFND 1 175,472 0 0
HILLTOP HOLDINGS INC COM 432748101 2,349 68,821 SH   DFND 1 68,821 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A203 27,576 228,053 SH   DFND 1 226,710 0 1,343
HOME BANCSHARES INC COM 436893200 2,651 97,991 SH   DFND 1 97,991 0 0
HOME DEPOT INC COM 437076102 508,985 1,667,434 SH   DFND 1 1,476,758 0 190,676
HOME DEPOT INC COM 437076102 6,449 21,128 SH   OTR 2 21,128 0 0
HOMESTREET INC COM 43785V102 915 20,772 SH   DFND 1 20,772 0 0
HONEYWELL INTL INC COM 438516106 389 1,794 SH   DFND 1 1,794 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 84,771 921,026 SH   DFND 1 918,196 0 2,830
HOULIHAN LOKEY INC CL A 441593100 24,156 363,188 SH   DFND 1 363,188 0 0
HOULIHAN LOKEY INC CL A 441593100 5,518 82,963 SH   OTR 2 82,963 0 0
HOWARD HUGHES CORP COM 44267D107 12,397 130,313 SH   DFND 1 130,313 0 0
HUBSPOT INC COM 443573100 57,001 125,494 SH   DFND 1 124,744 0 750
HUDSON EXECUTIVE INVT CORP COM CL A 443761101 11,126 1,121,598 SH   DFND 1 1,121,598 0 0
HUDSON EXECUTIVE INVT CORP COM CL A 443761101 2,747 276,929 SH   OTR 2 276,929 0 0
HUMANA INC COM 444859102 355,660 848,324 SH   DFND 1 771,747 0 76,577
HUNT J B TRANS SVCS INC COM 445658107 70,929 422,022 SH   DFND 1 420,118 0 1,904
HURON CONSULTING GROUP INC COM 447462102 13,438 266,727 SH   DFND 1 266,727 0 0
HURON CONSULTING GROUP INC COM 447462102 3,813 75,688 SH   OTR 2 75,688 0 0
I MAB SPONSORED ADS 44975P103 8,253 170,260 SH   DFND 1 170,260 0 0
IAA INC COM 449253103 21,467 389,317 SH   DFND 1 386,916 0 2,401
ILLUMINA INC COM 452327109 31,198 81,231 SH   DFND 1 81,231 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117 1,139 386,035 SH   DFND 1 386,035 0 0
INDEPENDENCE RLTY TR INC COM 45378A106 44,245 2,910,831 SH   DFND 1 2,910,831 0 0
INDEPENDENCE RLTY TR INC COM 45378A106 6,272 412,631 SH   OTR 2 412,631 0 0
INDUSTRIAL LOGISTICS PPTYS T COM SHS BEN INT 456237106 1,374 59,424 SH   DFND 1 59,424 0 0
INGEVITY CORP COM 45688C107 1,744 23,094 SH   DFND 1 23,094 0 0
INNOVAGE HLDG CORP COM 45784A104 12,250 475,000 SH   DFND 1 475,000 0 0
INPHI CORP COM 45772F107 850 4,766 SH   DFND 1 4,766 0 0
INSPIRE MED SYS INC COM 457730109 30,919 149,375 SH   DFND 1 149,375 0 0
INSPIRE MED SYS INC COM 457730109 7,491 36,191 SH   OTR 2 36,191 0 0
INSULET CORP COM 45784P101 66,425 254,580 SH   DFND 1 253,618 0 962
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 23,617 341,828 SH   DFND 1 341,828 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 3,453 49,975 SH   OTR 2 49,975 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 87,619 1,091,765 SH   DFND 1 1,091,765 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 3,861 48,106 SH   OTR 2 48,106 0 0
INTERNATIONAL BANCSHARES COR COM 459044103 2,343 50,474 SH   DFND 1 50,474 0 0
INTERSECT ENT INC COM 46071F103 15,455 740,175 SH   DFND 1 740,175 0 0
INTERSECT ENT INC COM 46071F103 3,671 175,823 SH   OTR 2 175,823 0 0
INTUIT COM 461202103 446 1,165 SH   DFND 1 1,165 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 627,655 849,399 SH   DFND 1 790,051 0 59,348
INTUITIVE SURGICAL INC COM NEW 46120E602 5,777 7,818 SH   OTR 2 7,818 0 0
INVESTORS BANCORP INC NEW COM 46146L101 1,327 90,313 SH   DFND 1 90,313 0 0
IQVIA HLDGS INC COM 46266C105 103,601 536,405 SH   DFND 1 534,689 0 1,716
IROBOT CORP COM 462726100 1,165 9,534 SH   DFND 1 9,534 0 0
IRON MTN INC NEW COM 46284V101 2,189 59,154 SH   DFND 1 59,154 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,188 106,282 SH   DFND 1 106,282 0 0
ISHARES TR MSCI ACWI ETF 464288257 6,943 72,971 SH   DFND 1 72,612 0 359
ISHARES TR MSCI ACWI EX US 464288240 5,005 90,711 SH   DFND 1 90,675 0 36
ISHARES TR NORTH AMERN NAT 464287374 201 7,279 SH   DFND 1 7,150 0 129
ISHARES TR RUS 1000 GRW ETF 464287614 8,395 34,541 SH   DFND 1 32,320 0 2,221
JACK IN THE BOX INC COM 466367109 58,339 531,418 SH   DFND 1 531,418 0 0
JACK IN THE BOX INC COM 466367109 7,632 69,518 SH   OTR 2 69,518 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 39,132 238,072 SH   DFND 1 237,504 0 568
JELD-WEN HLDG INC COM 47580P103 52,141 1,883,011 SH   DFND 1 1,883,011 0 0
JELD-WEN HLDG INC COM 47580P103 7,604 274,618 SH   OTR 2 274,618 0 0
JOHNSON CTLS INTL PLC SHS G51502105 208,235 3,489,774 SH   DFND 1 3,489,774 0 0
JPMORGAN CHASE & CO COM 46625H100 323,526 2,125,242 SH   DFND 1 2,044,795 0 80,447
KAMAN CORP COM 483548103 9,623 187,616 SH   DFND 1 187,616 0 0
KAMAN CORP COM 483548103 1,448 28,230 SH   OTR 2 28,230 0 0
KANSAS CITY SOUTHERN COM NEW 485170302 11,991 45,435 SH   DFND 1 45,435 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 909 86,381 SH   DFND 1 86,381 0 0
KB HOME COM 48666K109 1,985 42,664 SH   DFND 1 42,664 0 0
KENNAMETAL INC COM 489170100 32,996 825,533 SH   DFND 1 825,533 0 0
KENNAMETAL INC COM 489170100 5,770 144,354 SH   OTR 2 144,354 0 0
KEYSIGHT TECHNOLOGIES INC COM 49338L103 52,335 364,961 SH   DFND 1 350,238 0 14,723
KFORCE INC COM 493732101 1,161 21,656 SH   DFND 1 21,656 0 0
KINDER MORGAN INC DEL COM 49456B101 12,069 724,891 SH   DFND 1 724,891 0 0
KINROSS GOLD CORP COM 496902404 11,077 1,660,732 SH   DFND 1 1,659,761 0 971
KKR & CO INC COM 48251W104 6,870 140,635 SH   DFND 1 140,635 0 0
KNIGHT-SWIFT TRANSN HLDGS IN CL A 499049104 794 16,501 SH   DFND 1 16,501 0 0
KONTOOR BRANDS INC COM 50050N103 52,937 1,090,815 SH   DFND 1 1,090,815 0 0
KONTOOR BRANDS INC COM 50050N103 8,209 169,157 SH   OTR 2 169,157 0 0
KRAFT HEINZ CO COM 500754106 1,144 28,600 SH   DFND 1 28,600 0 0
KYMERA THERAPEUTICS INC COM 501575104 7,255 186,701 SH   DFND 1 186,701 0 0
L3HARRIS TECHNOLOGIES INC COM 502431109 35,066 173,013 SH   DFND 1 172,032 0 981
LABORATORY CORP AMER HLDGS COM NEW 50540R409 106,309 416,850 SH   DFND 1 416,850 0 0
LAM RESEARCH CORP COM 512807108 28,869 48,499 SH   DFND 1 48,487 0 12
LAS VEGAS SANDS CORP COM 517834107 921 15,152 SH   DFND 1 15,152 0 0
LATTICE SEMICONDUCTOR CORP COM 518415104 31,249 694,112 SH   DFND 1 694,112 0 0
LATTICE SEMICONDUCTOR CORP COM 518415104 4,624 102,702 SH   OTR 2 102,702 0 0
LAUDER ESTEE COS INC CL A 518439104 2,083,462 7,163,356 SH   DFND 1 6,853,062 0 310,294
LAUDER ESTEE COS INC CL A 518439104 26,259 90,282 SH   OTR 2 90,282 0 0
LAZARD LTD SHS A G54050102 46,216 1,062,199 SH   DFND 1 1,062,199 0 0
LAZARD LTD SHS A G54050102 4,080 93,765 SH   OTR 2 93,765 0 0
LENNAR CORP CL A 526057104 33,978 335,648 SH   DFND 1 333,767 0 1,881
LIBERTY OILFIELD SVCS INC COM CL A 53115L104 1,037 91,884 SH   DFND 1 91,884 0 0
LILLY ELI & CO COM 532457108 1,003,038 5,369,010 SH   DFND 1 5,143,297 0 225,713
LILLY ELI & CO COM 532457108 13,288 71,127 SH   OTR 2 71,127 0 0
LINCOLN ELEC HLDGS INC COM 533900106 20,449 166,331 SH   DFND 1 166,331 0 0
LINDE PLC SHS G5494J103 232,714 830,707 SH   DFND 1 830,687 0 20
LITTELFUSE INC COM 537008104 45,255 171,134 SH   DFND 1 171,134 0 0
LITTELFUSE INC COM 537008104 6,014 22,742 SH   OTR 2 22,742 0 0
LOWES COS INC COM 548661107 146,943 772,652 SH   DFND 1 772,652 0 0
LULULEMON ATHLETICA INC COM 550021109 1,682,793 5,486,592 SH   DFND 1 5,179,509 0 307,083
LULULEMON ATHLETICA INC COM 550021109 32,559 106,156 SH   OTR 2 106,156 0 0
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 1,766 16,970 SH   DFND 1 16,970 0 0
M/I HOMES INC COM 55305B101 1,030 17,443 SH   DFND 1 17,443 0 0
MACOM TECH SOLUTIONS HLDGS I COM 55405Y100 36,380 627,034 SH   DFND 1 627,034 0 0
MACOM TECH SOLUTIONS HLDGS I COM 55405Y100 6,442 111,030 SH   OTR 2 111,030 0 0
MACROGENICS INC COM 556099109 868 27,262 SH   DFND 1 27,262 0 0
MAG SILVER CORP COM 55903Q104 6,697 444,731 SH   DFND 1 444,459 0 272
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 11,123 256,538 SH   DFND 1 256,538 0 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 17,893 566,580 SH   DFND 1 566,580 0 0
MARINEMAX INC COM 567908108 1,408 28,523 SH   DFND 1 28,523 0 0
MARRIOTT INTL INC NEW CL A 571903202 8,603 58,086 SH   DFND 1 0 0 58,086
MARSH & MCLENNAN COS INC COM 571748102 88,286 724,848 SH   DFND 1 724,848 0 0
MARTEN TRANS LTD COM 573075108 985 58,019 SH   DFND 1 58,019 0 0
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 62,069 1,267,226 SH   DFND 1 1,259,220 0 8,006
MASTEC INC COM 576323109 2,088 22,286 SH   DFND 1 22,286 0 0
MASTERCARD INCORPORATED CL A 57636Q104 1,843,416 5,177,407 SH   DFND 1 4,954,651 0 222,756
MASTERCARD INCORPORATED CL A 57636Q104 23,841 66,961 SH   OTR 2 66,961 0 0
MATCH GROUP INC NEW COM 57667L107 3,060,776 22,279,632 SH   DFND 1 21,041,767 0 1,237,865
MATCH GROUP INC NEW COM 57667L107 89,262 649,743 SH   OTR 2 649,743 0 0
MAXIMUS INC COM 577933104 983 11,043 SH   DFND 1 11,043 0 0
MAXLINEAR INC COM 57776J100 21,350 626,466 SH   DFND 1 626,466 0 0
MAXLINEAR INC COM 57776J100 5,410 158,757 SH   OTR 2 158,757 0 0
MAYVILLE ENGINEERING CO INC COM 578605107 9,945 691,605 SH   DFND 1 691,605 0 0
MAYVILLE ENGINEERING CO INC COM 578605107 2,735 190,209 SH   OTR 2 190,209 0 0
MCDONALDS CORP COM 580135101 89,175 397,854 SH   DFND 1 391,700 0 6,154
MEDPACE HLDGS INC COM 58506Q109 2,216 13,508 SH   DFND 1 13,508 0 0
MEDTRONIC PLC SHS G5960L103 46,939 397,352 SH   DFND 1 397,352 0 0
MERCADOLIBRE INC COM 58733R102 2,148,750 1,459,610 SH   DFND 1 1,387,563 0 72,047
MERCADOLIBRE INC COM 58733R102 89,359 60,700 SH   OTR 2 60,700 0 0
MERIDIAN BIOSCIENCE INC COM 589584101 1,757 66,950 SH   DFND 1 66,950 0 0
MERITAGE HOMES CORP COM 59001A102 1,882 20,476 SH   DFND 1 20,476 0 0
METHODE ELECTRS INC COM 591520200 2,298 54,734 SH   DFND 1 54,734 0 0
METLIFE INC COM 59156R108 181,792 2,990,496 SH   DFND 1 2,990,496 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 1,810 1,566 SH   DFND 1 1,566 0 0
MGM RESORTS INTERNATIONAL COM 552953101 499 13,135 SH   DFND 1 13,135 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 59,423 382,833 SH   DFND 1 380,670 0 2,163
MICROSOFT CORP COM 594918104 4,734,876 20,082,604 SH   DFND 1 19,283,729 0 798,875
MICROSOFT CORP COM 594918104 51,252 217,383 SH   OTR 2 217,383 0 0
MIRATI THERAPEUTICS INC COM 60468T105 14,320 83,597 SH   DFND 1 83,597 0 0
MOELIS & CO CL A 60786M105 11,339 206,608 SH   DFND 1 206,608 0 0
MOELIS & CO CL A 60786M105 2,665 48,566 SH   OTR 2 48,566 0 0
MOLINA HEALTHCARE INC COM 60855R100 80,917 346,153 SH   DFND 1 344,998 0 1,155
MONDELEZ INTL INC CL A 609207105 118,111 2,017,955 SH   DFND 1 2,017,955 0 0
MONOLITHIC PWR SYS INC COM 609839105 36,241 102,606 SH   DFND 1 102,000 0 606
MOODYS CORP COM 615369105 5,209 17,445 SH   DFND 1 17,445 0 0
MPLX LP COM UNIT REP LTD 55336V100 24,852 969,645 SH   DFND 1 969,645 0 0
MUELLER WTR PRODS INC COM SER A 624758108 6,531 470,148 SH   DFND 1 470,148 0 0
MUELLER WTR PRODS INC COM SER A 624758108 1,791 128,966 SH   OTR 2 128,966 0 0
NATERA INC COM 632307104 115,440 1,136,896 SH   DFND 1 1,136,896 0 0
NATIONAL ENERGY SERVICES REU SHS G6375R107 10,612 857,913 SH   DFND 1 857,373 0 540
NATIONAL STORAGE AFFILIATES COM SHS BEN IN 637870106 33,233 832,281 SH   DFND 1 832,281 0 0
NATIONAL STORAGE AFFILIATES COM SHS BEN IN 637870106 6,937 173,734 SH   OTR 2 173,734 0 0
NATIONAL VISION HLDGS INC COM 63845R107 26,663 608,334 SH   DFND 1 608,334 0 0
NATIONAL VISION HLDGS INC COM 63845R107 6,675 152,291 SH   OTR 2 152,291 0 0
NEOGENOMICS INC COM NEW 64049M209 18,586 385,348 SH   DFND 1 385,348 0 0
NEOGENOMICS INC COM NEW 64049M209 4,457 92,418 SH   OTR 2 92,418 0 0
NETFLIX INC COM 64110L106 3,738,158 7,165,890 SH   DFND 1 6,769,387 0 396,503
NETFLIX INC COM 64110L106 78,914 151,274 SH   OTR 2 151,274 0 0
NEVRO CORP COM 64157F103 42,914 307,627 SH   DFND 1 307,627 0 0
NEVRO CORP COM 64157F103 6,449 46,228 SH   OTR 2 46,228 0 0
NEW FORTRESS ENERGY INC COM CL A 644393100 6,942 151,218 SH   DFND 1 151,170 0 48
NEW JERSEY RES CORP COM 646025106 2,645 66,353 SH   DFND 1 66,353 0 0
NEWMONT CORP COM 651639106 18,156 301,246 SH   DFND 1 301,057 0 189
NEXSTAR MEDIA GROUP INC CL A 65336K103 2,531 18,023 SH   DFND 1 18,023 0 0
NEXTERA ENERGY INC COM 65339F101 323,483 4,278,307 SH   DFND 1 4,261,541 0 16,766
NEXTERA ENERGY INC UNIT 99/99/9999 65339F739 9,765 196,885 SH   DFND 1 196,885 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 226,070 3,101,954 SH   DFND 1 3,101,845 0 109
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 8,878 121,812 SH   OTR 2 121,812 0 0
NICE LTD SPONSORED ADR 653656108 153,000 701,930 SH   DFND 1 701,809 0 121
NICE LTD SPONSORED ADR 653656108 2,130 9,774 SH   OTR 2 9,774 0 0
NIKE INC CL B 654106103 2,309,650 17,380,162 SH   DFND 1 16,453,894 0 926,268
NIKE INC CL B 654106103 42,416 319,183 SH   OTR 2 319,183 0 0
NLIGHT INC COM 65487K100 39,315 1,213,426 SH   DFND 1 1,213,426 0 0
NLIGHT INC COM 65487K100 6,468 199,624 SH   OTR 2 199,624 0 0
NORDSON CORP COM 655663102 36,726 184,851 SH   DFND 1 183,886 0 965
NORFOLK SOUTHN CORP COM 655844108 22,822 84,992 SH   DFND 1 84,992 0 0
NORTHWEST NAT HLDG CO COM 66765N105 1,232 22,835 SH   DFND 1 22,835 0 0
NOVAVAX INC COM NEW 670002401 35,945 198,250 SH   DFND 1 198,250 0 0
NOVO-NORDISK A S ADR 670100205 32,913 488,181 SH   DFND 1 488,181 0 0
NURIX THERAPEUTICS INC COM 67080M103 26,378 848,424 SH   DFND 1 848,424 0 0
NURIX THERAPEUTICS INC COM 67080M103 2,225 71,570 SH   OTR 2 71,570 0 0
NUSTAR ENERGY LP UNIT COM 67058H102 3,481 203,697 SH   DFND 1 203,697 0 0
NUTRIEN LTD COM 67077M108 10,868 201,679 SH   DFND 1 201,571 0 108
NUVASIVE INC COM 670704105 47,459 723,904 SH   DFND 1 723,904 0 0
NVIDIA CORPORATION COM 67066G104 3,741,701 7,007,849 SH   DFND 1 6,672,745 0 335,104
NVIDIA CORPORATION COM 67066G104 75,924 142,199 SH   OTR 2 142,199 0 0
NVR INC COM 62944T105 1,762 374 SH   DFND 1 374 0 0
OCEANEERING INTL INC COM 675232102 901 78,871 SH   DFND 1 78,871 0 0
OGE ENERGY CORP COM 670837103 32,220 995,667 SH   DFND 1 995,667 0 0
OKTA INC CL A 679295105 223,012 1,011,714 SH   DFND 1 990,641 0 21,073
OKTA INC CL A 679295105 4,649 21,089 SH   OTR 2 21,089 0 0
OLINK HLDG AB SPONSORED ADS 680710100 2,017 56,040 SH   DFND 1 56,040 0 0
ON SEMICONDUCTOR CORP COM 682189105 50,257 1,207,814 SH   DFND 1 1,202,490 0 5,324
ONEOK INC NEW COM 682680103 29,388 580,093 SH   DFND 1 580,093 0 0
OPEN LENDING CORP COM CL A 68373J104 17,824 503,223 SH   DFND 1 503,223 0 0
OPEN LENDING CORP COM CL A 68373J104 2,440 68,885 SH   OTR 2 68,885 0 0
ORACLE CORP COM 68389X105 8,055 114,793 SH   DFND 1 114,793 0 0
OREILLY AUTOMOTIVE INC COM 67103H107 56,757 111,891 SH   DFND 1 111,317 0 574
ORIC PHARMACEUTICALS INC COM 68622P109 25,660 1,047,376 SH   DFND 1 1,047,376 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 2,355 96,103 SH   OTR 2 96,103 0 0
ORTHO CLINICAL DIAGNOSTICS H ORD SHS G6829J107 15,557 806,278 SH   DFND 1 806,278 0 0
OSHKOSH CORP COM 688239201 370 3,115 SH   DFND 1 3,115 0 0
OTIS WORLDWIDE CORP COM 68902V107 74,356 1,086,276 SH   DFND 1 1,086,276 0 0
OUTSET MED INC COM 690145107 35,841 658,967 SH   DFND 1 658,967 0 0
OUTSET MED INC COM 690145107 2,977 54,729 SH   OTR 2 54,729 0 0
OVERSTOCK COM INC DEL COM 690370101 929 14,025 SH   DFND 1 14,025 0 0
PAGERDUTY INC COM 69553P100 26,534 659,571 SH   DFND 1 659,571 0 0
PAGERDUTY INC COM 69553P100 3,319 82,498 SH   OTR 2 82,498 0 0
PALO ALTO NETWORKS INC COM 697435105 47,929 148,821 SH   DFND 1 147,974 0 847
PARKER-HANNIFIN CORP COM 701094104 4,993 15,829 SH   DFND 1 15,829 0 0
PATRICK INDS INC COM 703343103 2,136 25,124 SH   DFND 1 25,124 0 0
PAYCOM SOFTWARE INC COM 70432V102 34,839 94,144 SH   DFND 1 93,565 0 579
PAYPAL HLDGS INC COM 70450Y103 2,609,561 10,746,010 SH   DFND 1 10,268,514 0 477,496
PAYPAL HLDGS INC COM 70450Y103 29,232 120,374 SH   OTR 2 120,374 0 0
PDC ENERGY INC COM 69327R101 87,548 2,545,002 SH   DFND 1 2,544,590 0 412
PDC ENERGY INC COM 69327R101 10,178 295,859 SH   OTR 2 295,859 0 0
PELOTON INTERACTIVE INC CL A COM 70614W100 1,249,589 11,113,379 SH   DFND 1 10,552,434 0 560,945
PELOTON INTERACTIVE INC CL A COM 70614W100 51,244 455,747 SH   OTR 2 455,747 0 0
PEMBINA PIPELINE CORP COM 706327103 26,793 928,211 SH   DFND 1 928,211 0 0
PENN NATL GAMING INC COM 707569109 18,361 175,136 SH   DFND 1 175,136 0 0
PEPSICO INC COM 713448108 98,230 694,448 SH   DFND 1 683,061 0 11,387
PERFORMANCE FOOD GROUP CO COM 71377A103 75,143 1,304,331 SH   DFND 1 1,304,331 0 0
PERFORMANCE FOOD GROUP CO COM 71377A103 11,019 191,274 SH   OTR 2 191,274 0 0
PG&E CORP COM 69331C108 75,626 6,458,254 SH   DFND 1 6,458,254 0 0
PHILIP MORRIS INTL INC COM 718172109 1,541 17,369 SH   DFND 1 17,369 0 0
PHILLIPS 66 PARTNERS LP COM UNIT REP INT 718549207 4,627 146,101 SH   DFND 1 146,101 0 0
PHREESIA INC COM 71944F106 69,258 1,329,342 SH   DFND 1 1,329,342 0 0
PHREESIA INC COM 71944F106 7,033 134,982 SH   OTR 2 134,982 0 0
PINNACLE FINL PARTNERS INC COM 72346Q104 66,353 748,393 SH   DFND 1 748,393 0 0
PINNACLE FINL PARTNERS INC COM 72346Q104 8,439 95,185 SH   OTR 2 95,185 0 0
PINTEREST INC CL A 72352L106 56,579 764,277 SH   DFND 1 759,605 0 4,672
PIONEER NAT RES CO COM 723787107 32,608 205,311 SH   DFND 1 205,192 0 119
PIONEER NAT RES CO COM 723787107 0 1 SH   OTR 2 1 0 0
PLAINS ALL AMERN PIPELINE L UNIT LTD PARTN 726503105 3,720 408,754 SH   DFND 1 408,754 0 0
PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207 15,802 1,681,094 SH   DFND 1 1,681,094 0 0
PLEXUS CORP COM 729132100 1,131 12,312 SH   DFND 1 12,312 0 0
PLUG POWER INC COM NEW 72919P202 15,887 443,287 SH   DFND 1 443,287 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 11,780 358,152 SH   DFND 1 358,152 0 0
PNC FINL SVCS GROUP INC COM 693475105 203,626 1,160,860 SH   DFND 1 1,160,860 0 0
POOL CORP COM 73278L105 2,114 6,122 SH   DFND 1 6,122 0 0
POTLATCHDELTIC CORPORATION COM 737630103 1,111 21,000 SH   DFND 1 21,000 0 0
PPD INC COM 69355F102 109,211 2,886,114 SH   DFND 1 2,876,013 0 10,101
PRAXIS PRECISION MEDICINES I COM 74006W108 6,470 197,510 SH   DFND 1 197,510 0 0
PRESTIGE CONSMR HEALTHCARE I COM 74112D101 13,265 300,947 SH   DFND 1 300,947 0 0
PRESTIGE CONSMR HEALTHCARE I COM 74112D101 3,708 84,109 SH   OTR 2 84,109 0 0
PRICE T ROWE GROUP INC COM 74144T108 4,032 23,499 SH   DFND 1 23,499 0 0
PRIMERICA INC COM 74164M108 4,553 30,804 SH   DFND 1 30,804 0 0
PRIMORIS SVCS CORP COM 74164F103 2,290 69,131 SH   DFND 1 69,131 0 0
PROCTER AND GAMBLE CO COM 742718109 99,060 731,447 SH   DFND 1 711,121 0 20,326
PROGYNY INC COM 74340E103 17,916 402,512 SH   DFND 1 401,483 0 1,029
PROGYNY INC COM 74340E103 2,895 65,036 SH   OTR 2 65,036 0 0
PROLOGIS INC. COM 74340W103 33,375 314,855 SH   DFND 1 314,855 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 17,189 2,600,427 SH   DFND 1 2,600,427 0 0
PROSIGHT GLOBAL INC COM 74349J103 4,688 372,058 SH   DFND 1 372,058 0 0
PTC INC COM 69370C100 90,492 657,410 SH   DFND 1 656,373 0 1,037
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 129,033 2,143,046 SH   DFND 1 2,143,046 0 0
Q2 HLDGS INC COM 74736L109 19,082 190,437 SH   DFND 1 190,437 0 0
Q2 HLDGS INC COM 74736L109 5,461 54,503 SH   OTR 2 54,503 0 0
QTS RLTY TR INC COM CL A 74736A103 20,582 331,758 SH   DFND 1 331,758 0 0
QTS RLTY TR INC COM CL A 74736A103 5,422 87,390 SH   OTR 2 87,390 0 0
QUALCOMM INC COM 747525103 70,605 532,504 SH   DFND 1 522,730 0 9,774
QUANEX BUILDING PRODUCTS COR COM 747619104 900 34,327 SH   DFND 1 34,327 0 0
QUANTA SVCS INC COM 74762E102 81,963 931,604 SH   DFND 1 928,146 0 3,458
RALPH LAUREN CORP CL A 751212101 10,320 83,790 SH   DFND 1 83,790 0 0
RAYTHEON TECHNOLOGIES CORP COM 75513E101 142,512 1,844,339 SH   DFND 1 1,844,339 0 0
REGENERON PHARMACEUTICALS COM 75886F107 4,760 10,061 SH   DFND 1 10,061 0 0
RENAISSANCERE HLDGS LTD COM G7496G103 54,804 341,990 SH   DFND 1 341,990 0 0
RENEWABLE ENERGY GROUP INC COM NEW 75972A301 4,862 73,629 SH   DFND 1 73,586 0 43
REPLIGEN CORP COM 759916109 37,520 192,993 SH   DFND 1 192,993 0 0
RETAIL OPPORTUNITY INVTS COR COM 76131N101 19,520 1,229,992 SH   DFND 1 1,229,992 0 0
RETAIL OPPORTUNITY INVTS COR COM 76131N101 2,582 162,685 SH   OTR 2 162,685 0 0
RETAIL PPTYS AMER INC CL A 76131V202 1,735 165,582 SH   DFND 1 165,582 0 0
REVANCE THERAPEUTICS INC COM 761330109 54,244 1,940,766 SH   DFND 1 1,940,766 0 0
REVANCE THERAPEUTICS INC COM 761330109 4,478 160,217 SH   OTR 2 160,217 0 0
REXNORD CORP COM 76169B102 62,856 1,334,810 SH   DFND 1 1,334,810 0 0
REXNORD CORP COM 76169B102 8,709 184,948 SH   OTR 2 184,948 0 0
RINGCENTRAL INC CL A 76680R206 1,484,342 4,983,020 SH   DFND 1 4,653,929 0 329,091
RINGCENTRAL INC CL A 76680R206 51,228 171,975 SH   OTR 2 171,975 0 0
ROBLOX CORP CL A 771049103 282,063 4,350,799 SH   DFND 1 4,203,037 0 147,762
ROBLOX CORP CL A 771049103 4,955 76,437 SH   OTR 2 76,437 0 0
ROSS STORES INC COM 778296103 111,084 926,393 SH   DFND 1 926,386 0 7
ROYAL CARIBBEAN GROUP COM V7780T103 53,207 621,499 SH   DFND 1 621,499 0 0
ROYAL DUTCH SHELL PLC SPONS ADR A 780259206 10,284 262,286 SH   DFND 1 262,140 0 146
ROYAL GOLD INC COM 780287108 14,674 136,351 SH   DFND 1 136,351 0 0
RUSH ENTERPRISES INC CL A 781846209 29,802 598,075 SH   DFND 1 598,075 0 0
RUSH ENTERPRISES INC CL A 781846209 4,512 90,553 SH   OTR 2 90,553 0 0
RUSH STREET INTERACTIVE INC COM 782011100 23,345 1,428,711 SH   DFND 1 1,428,711 0 0
RUSH STREET INTERACTIVE INC COM 782011100 3,151 192,821 SH   OTR 2 192,821 0 0
S&P GLOBAL INC COM 78409V104 468,567 1,327,876 SH   DFND 1 1,225,219 0 102,657
S&P GLOBAL INC COM 78409V104 7,083 20,072 SH   OTR 2 20,072 0 0
SAGE THERAPEUTICS INC COM 78667J108 41,881 559,526 SH   DFND 1 559,526 0 0
SAGE THERAPEUTICS INC PUT OPTIONS 78667J108 5,898 78,800 SH Put DFND 1 78,800 0 0
SAIA INC COM 78709Y105 99,114 429,846 SH   DFND 1 429,846 0 0
SAIA INC COM 78709Y105 14,694 63,725 SH   OTR 2 63,725 0 0
SALESFORCE COM INC COM 79466L302 1,731,025 8,170,226 SH   DFND 1 7,575,766 0 594,460
SALESFORCE COM INC COM 79466L302 19,895 93,900 SH   OTR 2 93,900 0 0
SAREPTA THERAPEUTICS INC COM 803607100 4,631 62,133 SH   DFND 1 62,133 0 0
SBA COMMUNICATIONS CORP NEW CL A 78410G104 17,168 61,856 SH   DFND 1 61,818 0 38
SCHLUMBERGER LTD COM 806857108 6,864 252,454 SH   DFND 1 252,311 0 143
SCHWEITZER-MAUDUIT INTL INC COM 808541106 869 17,748 SH   DFND 1 17,748 0 0
SCRIPPS E W CO OHIO CL A NEW 811054402 1,150 59,683 SH   DFND 1 59,683 0 0
SEA LTD SPONSORD ADS 81141R100 695,368 3,115,029 SH   DFND 1 2,908,640 0 206,389
SEA LTD SPONSORD ADS 81141R100 38,893 174,227 SH   OTR 2 174,227 0 0
SEACOAST BKG CORP FLA COM NEW 811707801 5,552 153,186 SH   DFND 1 153,186 0 0
SEACOAST BKG CORP FLA COM NEW 811707801 563 15,549 SH   OTR 2 15,549 0 0
SEAGEN INC COM 81181C104 9,703 69,873 SH   DFND 1 69,863 0 10
SEER INC COM CL A 81578P106 9,245 184,826 SH   DFND 1 184,826 0 0
SELECT MED HLDGS CORP COM 81619Q105 2,565 75,229 SH   DFND 1 75,229 0 0
SELECT SECTOR SPDR TR ENERGY 81369Y506 574 11,710 SH   DFND 1 11,603 0 107
SEMPRA ENERGY COM 816851109 91,263 688,358 SH   DFND 1 688,358 0 0
SERVICE CORP INTL COM 817565104 2,287 44,791 SH   DFND 1 44,791 0 0
SERVICENOW INC COM 81762P102 515,058 1,029,888 SH   DFND 1 1,012,986 0 16,902
SERVICENOW INC COM 81762P102 5,884 11,766 SH   OTR 2 11,766 0 0
SERVISFIRST BANCSHARES INC COM 81768T108 931 15,173 SH   DFND 1 15,173 0 0
SHIFT4 PMTS INC CL A 82452J109 51,317 625,751 SH   DFND 1 622,937 0 2,814
SHIFT4 PMTS INC CL A 82452J109 1,922 23,431 SH   OTR 2 23,431 0 0
SHOALS TECHNOLOGIES GROUP IN CL A 82489W107 3,783 108,782 SH   DFND 1 108,720 0 62
SHOCKWAVE MED INC COM 82489T104 68,636 526,914 SH   DFND 1 526,914 0 0
SHOPIFY INC CL A 82509L107 5,041,255 4,556,037 SH   DFND 1 4,383,380 0 172,657
SHOPIFY INC CL A 82509L107 105,536 95,378 SH   OTR 2 95,378 0 0
SIGNIFY HEALTH INC CL A COM 82671G100 4,256 145,451 SH   DFND 1 145,451 0 0
SILK RD MED INC COM 82710M100 16,147 318,808 SH   DFND 1 318,808 0 0
SILK RD MED INC COM 82710M100 2,278 44,969 SH   OTR 2 44,969 0 0
SILVERGATE CAP CORP CL A 82837P408 12,227 86,007 SH   DFND 1 86,007 0 0
SILVERGATE CAP CORP CL A 82837P408 1,807 12,708 SH   OTR 2 12,708 0 0
SIMULATIONS PLUS INC COM 829214105 963 15,226 SH   DFND 1 15,226 0 0
SITE CTRS CORP COM 82981J109 1,529 112,790 SH   DFND 1 112,790 0 0
SITEONE LANDSCAPE SUPPLY INC COM 82982L103 273 1,599 SH   DFND 1 1,599 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 736 15,842 SH   DFND 1 15,842 0 0
SLM CORP COM 78442P106 104,318 5,805,112 SH   DFND 1 5,805,112 0 0
SMARTSHEET INC COM CL A 83200N103 21,583 337,654 SH   DFND 1 337,654 0 0
SMITH & WESSON BRANDS INC COM 831754106 935 53,555 SH   DFND 1 53,555 0 0
SNAP INC CL A 83304A106 1,975,207 37,774,076 SH   DFND 1 35,676,108 0 2,097,968
SNAP INC CL A 83304A106 56,257 1,075,871 SH   OTR 2 1,075,871 0 0
SNOWFLAKE INC CL A 833445109 726,827 3,170,038 SH   DFND 1 2,975,814 0 194,224
SNOWFLAKE INC CL A 833445109 19,674 85,809 SH   OTR 2 85,809 0 0
SOC TELEMED INC COM CL A 78472F101 2,147 341,306 SH   DFND 1 341,306 0 0
SOUTHERN CO COM 842587107 60,029 965,710 SH   DFND 1 965,710 0 0
SOUTHERN COPPER CORP COM 84265V105 20,728 305,413 SH   DFND 1 305,241 0 172
SOUTHWEST AIRLS CO COM 844741108 1,000 16,376 SH   DFND 1 16,376 0 0
SPDR S&P MIDCAP 400 ETF TR UTSER1 S&PDCRP 78467Y107 354 744 SH   DFND 1 744 0 0
SPDR SER TR S&P METALS MNG 78464A755 5,637 141,216 SH   DFND 1 139,999 0 1,217
SPLUNK INC COM 848637104 90,426 667,452 SH   DFND 1 459,876 0 207,576
SPOTIFY TECHNOLOGY S A SHS L8681T102 1,551,765 5,791,248 SH   DFND 1 5,675,206 0 116,042
SPOTIFY TECHNOLOGY S A SHS L8681T102 18,468 68,925 SH   OTR 2 68,925 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 13,617 185,085 SH   DFND 1 185,085 0 0
SPROUTS FMRS MKT INC COM 85208M102 24,379 915,835 SH   DFND 1 915,835 0 0
SPROUTS FMRS MKT INC COM 85208M102 2,607 97,921 SH   OTR 2 97,921 0 0
SQUARE INC CL A 852234103 2,144,364 9,444,457 SH   DFND 1 8,955,954 0 488,503
SQUARE INC CL A 852234103 53,556 235,879 SH   OTR 2 235,879 0 0
STAG INDL INC COM 85254J102 1,242 36,948 SH   DFND 1 36,948 0 0
STAMPS COM INC COM NEW 852857200 37,100 185,954 SH   DFND 1 185,954 0 0
STAMPS COM INC COM NEW 852857200 4,997 25,047 SH   OTR 2 25,047 0 0
STARWOOD PPTY TR INC COM 85571B105 16,939 684,677 SH   DFND 1 684,677 0 0
STEEL DYNAMICS INC COM 858119100 12,069 237,762 SH   DFND 1 237,614 0 148
STEWART INFORMATION SVCS COR COM 860372101 885 17,001 SH   DFND 1 17,001 0 0
STRATASYS LTD SHS M85548101 223 8,603 SH   DFND 1 8,603 0 0
STRIDE INC COM 86333M108 1,140 37,849 SH   DFND 1 37,849 0 0
STRYKER CORPORATION COM 863667101 453 1,859 SH   DFND 1 1,859 0 0
SUMMIT HOTEL PPTYS INC COM 866082100 17,853 1,757,182 SH   DFND 1 1,757,182 0 0
SUMMIT HOTEL PPTYS INC COM 866082100 2,918 287,227 SH   OTR 2 287,227 0 0
SUMMIT MATLS INC CL A 86614U100 74,955 2,675,051 SH   DFND 1 2,675,051 0 0
SUMMIT MATLS INC CL A 86614U100 10,085 359,934 SH   OTR 2 359,934 0 0
SUN CTRY AIRLS HLDGS INC COM 866683105 4,442 129,576 SH   DFND 1 129,576 0 0
SUN CTRY AIRLS HLDGS INC COM 866683105 657 19,167 SH   OTR 2 19,167 0 0
SUNCOR ENERGY INC NEW COM 867224107 12,556 600,767 SH   DFND 1 600,404 0 363
SUNNOVA ENERGY INTL INC. COM 86745K104 29,968 734,150 SH   DFND 1 733,992 0 158
SUNRUN INC COM 86771W105 27,812 459,850 SH   DFND 1 459,771 0 79
SYKES ENTERPRISES INC COM 871237103 1,901 43,118 SH   DFND 1 43,118 0 0
SYNEOS HEALTH INC CL A 87166B102 30,853 406,769 SH   DFND 1 406,769 0 0
SYNEOS HEALTH INC CL A 87166B102 5,116 67,449 SH   OTR 2 67,449 0 0
SYSCO CORP COM 871829107 623 7,906 SH   DFND 1 7,906 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 1,571,743 13,288,322 SH   DFND 1 13,140,168 0 148,154
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 29,125 246,239 SH   OTR 2 246,239 0 0
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 27,274 154,353 SH   DFND 1 153,553 0 800
TANDEM DIABETES CARE INC COM NEW 875372203 41,638 471,825 SH   DFND 1 471,825 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 3,981 45,109 SH   OTR 2 45,109 0 0
TARGA RES CORP COM 87612G101 115,270 3,630,552 SH   DFND 1 3,630,552 0 0
TARGET CORP COM 87612E106 877,292 4,429,202 SH   DFND 1 4,297,144 0 132,058
TARGET CORP COM 87612E106 16,860 85,123 SH   OTR 2 85,123 0 0
TC ENERGY CORP COM 87807B107 12,051 262,768 SH   DFND 1 262,768 0 0
TELADOC HEALTH INC COM 87918A105 252,410 1,388,776 SH   DFND 1 1,224,037 0 164,739
TELADOC HEALTH INC COM 87918A105 2,435 13,397 SH   OTR 2 13,397 0 0
TELEFLEX INCORPORATED COM 879369106 52,969 127,496 SH   DFND 1 126,958 0 538
TELUS INTL CDA INC SUB VTG SHS 87975H100 18,141 648,370 SH   DFND 1 648,370 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 1,368 26,308 SH   DFND 1 26,308 0 0
TERADATA CORP DEL COM 88076W103 1,477 38,313 SH   DFND 1 38,313 0 0
TESLA INC COM 88160R101 7,024,309 10,516,535 SH   DFND 1 10,002,115 0 514,420
TESLA INC COM 88160R101 149,258 223,463 SH   OTR 2 223,463 0 0
TEXAS INSTRS INC COM 882508104 230,760 1,221,018 SH   DFND 1 1,221,018 0 0
TEXAS ROADHOUSE INC COM 882681109 23,764 247,697 SH   DFND 1 246,233 0 1,464
TFI INTL INC COM 87241L109 29,492 394,494 SH   DFND 1 394,494 0 0
TFI INTL INC COM 87241L109 3,779 50,544 SH   OTR 2 50,544 0 0
THE TRADE DESK INC COM CL A 88339J105 1,367,784 2,098,923 SH   DFND 1 1,971,735 0 127,188
THE TRADE DESK INC COM CL A 88339J105 37,334 57,290 SH   OTR 2 57,290 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 7,847 17,195 SH   DFND 1 17,195 0 0
TIMKEN CO COM 887389104 1,356 16,705 SH   DFND 1 16,705 0 0
TJX COS INC NEW COM 872540109 1,340,243 20,260,664 SH   DFND 1 19,392,932 0 867,732
TJX COS INC NEW COM 872540109 18,658 282,052 SH   OTR 2 282,052 0 0
TOLL BROTHERS INC COM 889478103 5,476 96,527 SH   DFND 1 96,527 0 0
TOTAL SE SPONSORED ADS 89151E109 42,269 908,235 SH   DFND 1 908,043 0 192
TOWER SEMICONDUCTOR LTD SHS NEW M87915274 43,980 1,568,472 SH   DFND 1 1,568,472 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274 6,413 228,701 SH   OTR 2 228,701 0 0
TPI COMPOSITES INC COM 87266J104 4,869 86,289 SH   DFND 1 86,236 0 53
TRACTOR SUPPLY CO COM 892356106 2,648 14,956 SH   DFND 1 14,956 0 0
TRANE TECHNOLOGIES PLC SHS G8994E103 43,625 263,498 SH   DFND 1 261,967 0 1,531
TRI POINTE HOMES INC COM 87265H109 1,210 59,426 SH   DFND 1 59,426 0 0
TRINET GROUP INC COM 896288107 1,825 23,414 SH   DFND 1 23,414 0 0
TRINITY INDS INC COM 896522109 20,126 706,412 SH   DFND 1 706,412 0 0
TRINITY INDS INC COM 896522109 5,151 180,802 SH   OTR 2 180,802 0 0
TRONOX HOLDINGS PLC SHS G9087Q102 1,346 73,569 SH   DFND 1 73,569 0 0
TRUIST FINL CORP COM 89832Q109 154,923 2,656,433 SH   DFND 1 2,656,433 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 77,619 820,583 SH   DFND 1 820,583 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 3,711 39,228 SH   OTR 2 39,228 0 0
TWILIO INC CL A 90138F102 2,610,089 7,659,611 SH   DFND 1 7,243,813 0 415,798
TWILIO INC CL A 90138F102 65,734 192,905 SH   OTR 2 192,905 0 0
TWIST BIOSCIENCE CORP COM 90184D100 12,627 101,942 SH   DFND 1 101,942 0 0
U S CONCRETE INC COM 90333L201 1,498 20,425 SH   DFND 1 20,425 0 0
UBER TECHNOLOGIES INC COM 90353T100 2,516,767 46,170,747 SH   DFND 1 44,128,257 0 2,042,490
UBER TECHNOLOGIES INC COM 90353T100 30,076 551,753 SH   OTR 2 551,753 0 0
UFP INDUSTRIES INC COM 90278Q108 1,825 24,064 SH   DFND 1 24,064 0 0
UMB FINL CORP COM 902788108 2,265 24,534 SH   DFND 1 24,534 0 0
UMH PPTYS INC COM 903002103 1,969 102,747 SH   DFND 1 102,747 0 0
UMH PPTYS INC COM 903002103 543 28,302 SH   OTR 2 28,302 0 0
UNION PAC CORP COM 907818108 1,218,607 5,528,819 SH   DFND 1 5,259,397 0 269,422
UNION PAC CORP COM 907818108 16,124 73,155 SH   OTR 2 73,155 0 0
UNITED PARCEL SERVICE INC CL B 911312106 13,354 78,555 SH   DFND 1 78,555 0 0
UNITED RENTALS INC COM 911363109 95,010 288,511 SH   DFND 1 288,511 0 0
UNITEDHEALTH GROUP INC COM 91324P102 236,984 636,934 SH   DFND 1 604,360 0 32,574
UNIVERSAL DISPLAY CORP COM 91347P105 55,090 232,673 SH   DFND 1 231,855 0 818
UPWORK INC COM 91688F104 973 21,727 SH   DFND 1 21,727 0 0
URBAN EDGE PPTYS COM 91704F104 2,005 121,382 SH   DFND 1 121,382 0 0
UTZ BRANDS INC COM CL A 918090101 15,833 638,711 SH   DFND 1 638,711 0 0
UTZ BRANDS INC COM CL A 918090101 4,212 169,892 SH   OTR 2 169,892 0 0
VALE S A SPONSORED ADS 91912E105 10,796 621,168 SH   DFND 1 620,809 0 359
VALERO ENERGY CORP COM 91913Y100 5,922 82,707 SH   DFND 1 82,671 0 36
VANGUARD INDEX FDS GROWTH ETF 922908736 559 2,176 SH   DFND 1 2,176 0 0
VARONIS SYS INC COM 922280102 45,838 892,826 SH   DFND 1 892,826 0 0
VARONIS SYS INC COM 922280102 8,034 156,491 SH   OTR 2 156,491 0 0
VERACYTE INC COM 92337F107 36,467 678,440 SH   DFND 1 676,699 0 1,741
VERACYTE INC COM 92337F107 3,249 60,454 SH   OTR 2 60,454 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 88,076 1,514,641 SH   DFND 1 1,480,483 0 34,158
VERTEX PHARMACEUTICALS INC CALL OPTIONS 92532F100 6,447 30,000 SH Call DFND 1 0 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 153,816 715,789 SH   DFND 1 590,317 0 125,472
VISA INC COM CL A 92826C839 2,718,533 12,839,620 SH   DFND 1 12,238,004 0 601,616
VISA INC COM CL A 92826C839 32,888 155,332 SH   OTR 2 155,332 0 0
VROOM INC COM 92918V109 23,017 590,329 SH   DFND 1 590,329 0 0
VROOM INC COM 92918V109 2,746 70,431 SH   OTR 2 70,431 0 0
WABTEC COM 929740108 8,608 108,740 SH   DFND 1 108,740 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 45,227 823,805 SH   DFND 1 823,805 0 0
WALMART INC COM 931142103 184,106 1,355,412 SH   DFND 1 1,343,969 0 11,443
WASTE CONNECTIONS INC COM 94106B101 4,797 44,422 SH   DFND 1 44,422 0 0
WERNER ENTERPRISES INC COM 950755108 1,363 28,897 SH   DFND 1 28,897 0 0
WEST PHARMACEUTICAL SVSC INC COM 955306105 4,887 17,344 SH   DFND 1 17,344 0 0
WESTERN MIDSTREAM PARTNERS L COM UNIT LP INT 958669103 24,738 1,330,737 SH   DFND 1 1,330,737 0 0
WESTERN UN CO COM 959802109 1,585 64,294 SH   DFND 1 64,294 0 0
WESTLAKE CHEM CORP COM 960413102 2,172 24,466 SH   DFND 1 24,466 0 0
WEX INC COM 96208T104 39,308 187,877 SH   DFND 1 187,306 0 571
WHEATON PRECIOUS METALS CORP COM 962879102 4,743 124,132 SH   DFND 1 124,054 0 78
WILLIAMS COS INC COM 969457100 167,660 7,077,228 SH   DFND 1 7,077,228 0 0
WILLIAMS SONOMA INC COM 969904101 2,122 11,844 SH   DFND 1 11,844 0 0
WILLSCOT MOBIL MINI HLDNG CO COM CL A 971378104 81,924 2,952,196 SH   DFND 1 2,952,196 0 0
WILLSCOT MOBIL MINI HLDNG CO COM CL A 971378104 11,511 414,824 SH   OTR 2 414,824 0 0
WINGSTOP INC COM 974155103 27,023 212,498 SH   DFND 1 212,498 0 0
WINGSTOP INC COM 974155103 6,629 52,127 SH   OTR 2 52,127 0 0
WINTRUST FINL CORP COM 97650W108 40,657 536,366 SH   DFND 1 536,366 0 0
WINTRUST FINL CORP COM 97650W108 5,529 72,943 SH   OTR 2 72,943 0 0
WIX COM LTD SHS M98068105 385,101 1,379,203 SH   DFND 1 1,302,792 0 76,411
WIX COM LTD SHS M98068105 19,249 68,938 SH   OTR 2 68,938 0 0
WORKDAY INC CL A 98138H101 1,105,682 4,450,677 SH   DFND 1 4,186,076 0 264,601
WORKDAY INC CL A 98138H101 13,118 52,804 SH   OTR 2 52,804 0 0
WSFS FINL CORP COM 929328102 23,447 470,914 SH   DFND 1 470,914 0 0
WSFS FINL CORP COM 929328102 3,709 74,496 SH   OTR 2 74,496 0 0
XCEL ENERGY INC COM 98389B100 55,086 828,243 SH   DFND 1 828,243 0 0
XILINX INC COM 983919101 31,598 255,028 SH   DFND 1 253,639 0 1,389
YETI HLDGS INC COM 98585X104 42,655 590,711 SH   DFND 1 587,295 0 3,416
YUM BRANDS INC COM 988498101 2,452 22,667 SH   DFND 1 22,667 0 0
ZAI LAB LTD ADR 98887Q104 179,881 1,348,129 SH   DFND 1 1,347,626 0 503
ZEBRA TECHNOLOGIES CORPORATI CL A 989207105 1,522 3,136 SH   DFND 1 3,136 0 0
ZENDESK INC COM 98936J101 23,064 173,914 SH   DFND 1 172,899 0 1,015
ZIMMER BIOMET HOLDINGS INC COM 98956P102 162,507 1,015,162 SH   DFND 1 1,015,162 0 0
ZOETIS INC CL A 98978V103 6,608 41,961 SH   DFND 1 0 0 41,961
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 444,941 1,384,859 SH   DFND 1 1,325,446 0 59,413
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 16,414 51,088 SH   OTR 2 51,088 0 0
ZUMIEZ INC COM 989817101 2,000 46,626 SH   DFND 1 46,626 0 0