<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0101</schemaVersion>

    <submissionType>EFFECT</submissionType>

    <act>33</act>

    <testOrLive>LIVE</testOrLive>

    <effectiveData>
        <finalEffectivenessDispDate>2007-11-29</finalEffectivenessDispDate>
        <finalEffectivenessDispTime>16:00:00</finalEffectivenessDispTime>
        <form>N-14</form>
        <filer>
            <cik>0000049702</cik>
            <entityName>RIVERSOURCE LARGE CAP SERIES, INC.</entityName>
            <fileNumber>333-146692</fileNumber>
            <seriesClassContractData>
                <merger>
                    <acquiringCik>0000049702</acquiringCik>
                    <acquiringEntityName>RIVERSOURCE LARGE CAP SERIES, INC.</acquiringEntityName>
                    <acquiringSeriesId>S000003288</acquiringSeriesId>
                    <acquiringSeriesName>RiverSource Growth Fund</acquiringSeriesName>
                    <acquiringClassContractId>C000008746</acquiringClassContractId>
                    <acquiringClassContractName>RiverSource Growth Fund Class A</acquiringClassContractName>
                    <targetCik>0001137342</targetCik>
                    <targetEntityName>RIVERSOURCE MANAGERS SERIES, INC.</targetEntityName>
                    <targetSeriesId>S000003329</targetSeriesId>
                    <targetSeriesName>RiverSource Fundamental Growth Fund</targetSeriesName>
                    <targetClassContractId>C000009021</targetClassContractId>
                    <targetClassContractName>RiverSource Fundamental Growth Fund Class A</targetClassContractName>
                </merger>
                <merger>
                    <acquiringCik>0000049702</acquiringCik>
                    <acquiringEntityName>RIVERSOURCE LARGE CAP SERIES, INC.</acquiringEntityName>
                    <acquiringSeriesId>S000003288</acquiringSeriesId>
                    <acquiringSeriesName>RiverSource Growth Fund</acquiringSeriesName>
                    <acquiringClassContractId>C000008747</acquiringClassContractId>
                    <acquiringClassContractName>RiverSource Growth Fund Class B</acquiringClassContractName>
                    <targetCik>0001137342</targetCik>
                    <targetEntityName>RIVERSOURCE MANAGERS SERIES, INC.</targetEntityName>
                    <targetSeriesId>S000003329</targetSeriesId>
                    <targetSeriesName>RiverSource Fundamental Growth Fund</targetSeriesName>
                    <targetClassContractId>C000009018</targetClassContractId>
                    <targetClassContractName>RiverSource Fundamental Growth Fund Class B</targetClassContractName>
                </merger>
                <merger>
                    <acquiringCik>0000049702</acquiringCik>
                    <acquiringEntityName>RIVERSOURCE LARGE CAP SERIES, INC.</acquiringEntityName>
                    <acquiringSeriesId>S000003288</acquiringSeriesId>
                    <acquiringSeriesName>RiverSource Growth Fund</acquiringSeriesName>
                    <acquiringClassContractId>C000008748</acquiringClassContractId>
                    <acquiringClassContractName>RiverSource Growth Fund Class C</acquiringClassContractName>
                    <targetCik>0001137342</targetCik>
                    <targetEntityName>RIVERSOURCE MANAGERS SERIES, INC.</targetEntityName>
                    <targetSeriesId>S000003329</targetSeriesId>
                    <targetSeriesName>RiverSource Fundamental Growth Fund</targetSeriesName>
                    <targetClassContractId>C000009019</targetClassContractId>
                    <targetClassContractName>RiverSource Fundamental Growth Fund Class C</targetClassContractName>
                </merger>
                <merger>
                    <acquiringCik>0000049702</acquiringCik>
                    <acquiringEntityName>RIVERSOURCE LARGE CAP SERIES, INC.</acquiringEntityName>
                    <acquiringSeriesId>S000003288</acquiringSeriesId>
                    <acquiringSeriesName>RiverSource Growth Fund</acquiringSeriesName>
                    <acquiringClassContractId>C000008749</acquiringClassContractId>
                    <acquiringClassContractName>RiverSource Growth Fund Class I</acquiringClassContractName>
                    <targetCik>0001137342</targetCik>
                    <targetEntityName>RIVERSOURCE MANAGERS SERIES, INC.</targetEntityName>
                    <targetSeriesId>S000003329</targetSeriesId>
                    <targetSeriesName>RiverSource Fundamental Growth Fund</targetSeriesName>
                    <targetClassContractId>C000009022</targetClassContractId>
                    <targetClassContractName>RiverSource Fundamental Growth Fund Class I</targetClassContractName>
                </merger>
                <merger>
                    <acquiringCik>0000049702</acquiringCik>
                    <acquiringEntityName>RIVERSOURCE LARGE CAP SERIES, INC.</acquiringEntityName>
                    <acquiringSeriesId>S000003288</acquiringSeriesId>
                    <acquiringSeriesName>RiverSource Growth Fund</acquiringSeriesName>
                    <acquiringClassContractId>C000042896</acquiringClassContractId>
                    <acquiringClassContractName>RiverSource Growth Fund Class R4</acquiringClassContractName>
                    <targetCik>0001137342</targetCik>
                    <targetEntityName>RIVERSOURCE MANAGERS SERIES, INC.</targetEntityName>
                    <targetSeriesId>S000003329</targetSeriesId>
                    <targetSeriesName>RiverSource Fundamental Growth Fund</targetSeriesName>
                    <targetClassContractId>C000043101</targetClassContractId>
                    <targetClassContractName>RiverSource Fundamental Growth Fund Class R4</targetClassContractName>
                </merger>
            </seriesClassContractData>
        </filer>
    </effectiveData>
</edgarSubmission>
