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            <regFileNumber>811-03386</regFileNumber>
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            <regStreet1>100 FEDERAL STREET</regStreet1>
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            <repPdEnd>2022-08-31</repPdEnd>
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                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
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                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>DEXCOM INC</name>
                <lei>549300YSK3QDSFR5EU59</lei>
                <title>COMMON STOCK</title>
                <cusip>252131107</cusip>
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                    <isin value="US2521311074"/>
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                <balance>59600</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>24669036</valUSD>
                <pctVal>1.535017586527</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
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                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
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            </invstOrSec>
            <invstOrSec>
                <name>HCA HEALTHCARE INC</name>
                <lei>529900PH4ZGUH2MNEU89</lei>
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                <cusip>40412C101</cusip>
                <identifiers>
                    <isin value="US40412C1018"/>
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                <balance>92800</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>23228768</valUSD>
                <pctVal>1.445397679640</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
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                    <isCashCollateral>N</isCashCollateral>
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                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>HORIZON THERAPEUTICS PLC</name>
                <lei>529900P0GSQ79OOZEV53</lei>
                <title>COMMON STOCK</title>
                <cusip>G46188101</cusip>
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                    <isin value="IE00BQPVQZ61"/>
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                <balance>135000</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>12307950</valUSD>
                <pctVal>0.765855613657</pctVal>
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                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
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                    <isCashCollateral>N</isCashCollateral>
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                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>ABBVIE INC</name>
                <lei>FR5LCKFTG8054YNNRU85</lei>
                <title>COMMON STOCK</title>
                <cusip>00287Y109</cusip>
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                    <isin value="US00287Y1091"/>
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                <balance>672000</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>99301440</valUSD>
                <pctVal>6.178979055666</pctVal>
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                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
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                    <isCashCollateral>N</isCashCollateral>
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            <invstOrSec>
                <name>ZOETIS INC</name>
                <lei>549300HD9Q1LOC9KLJ48</lei>
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                <cusip>98978V103</cusip>
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                    <isin value="US98978V1035"/>
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                <balance>145400</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>28156710</valUSD>
                <pctVal>1.752036238009</pctVal>
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                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
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                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>TURNING POINT THERAPEUTICS INC</name>
                <lei>N/A</lei>
                <title>COMMON STOCK</title>
                <cusip>90041T108</cusip>
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                    <isin value="US90041T1088"/>
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                <balance>118800</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>3761208</valUSD>
                <pctVal>0.234039158506</pctVal>
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                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
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                    <isLoanByFund>N</isLoanByFund>
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            <invstOrSec>
                <name>4FRONT VENTURES CORP</name>
                <lei>N/A</lei>
                <title>COMMON STOCK</title>
                <cusip>35086B207</cusip>
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                    <isin value="CA35086B2075"/>
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                <balance>30875517</balance>
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                <curCd>USD</curCd>
                <valUSD>26244189.45</valUSD>
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                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
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                    <isLoanByFund>N</isLoanByFund>
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            <invstOrSec>
                <name>GREEN THUMB INDUSTRIES INC</name>
                <lei>529900Q0L3K192QQY915</lei>
                <title>COMMON STOCK</title>
                <cusip>39342L108</cusip>
                <identifiers>
                    <isin value="CA39342L1085"/>
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                <balance>282700</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>5405224</valUSD>
                <pctVal>0.336337175847</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <loanByFundCondition isLoanByFund="Y" loanVal="4864128"/>
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            </invstOrSec>
            <invstOrSec>
                <name>CVS HEALTH CORP</name>
                <lei>549300EJG376EN5NQE29</lei>
                <title>COMMON STOCK</title>
                <cusip>126650100</cusip>
                <identifiers>
                    <isin value="US1266501006"/>
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                <balance>205000</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>21248250</valUSD>
                <pctVal>1.322161005113</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>DANAHER CORP</name>
                <lei>S4BKK9OTCEWQ3YHPFM11</lei>
                <title>COMMON STOCK</title>
                <cusip>235851102</cusip>
                <identifiers>
                    <isin value="US2358511028"/>
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                <balance>248100</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>68081121</valUSD>
                <pctVal>4.236311384259</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>UNITEDHEALTH GROUP INC</name>
                <lei>549300GHBMY8T5GXDE41</lei>
                <title>COMMON STOCK</title>
                <cusip>91324P102</cusip>
                <identifiers>
                    <isin value="US91324P1021"/>
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                <balance>304800</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>145045176</valUSD>
                <pctVal>9.025358591270</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>IMMUNOGEN INC</name>
                <lei>54930084U0R1OP766Y02</lei>
                <title>COMMON STOCK</title>
                <cusip>45253H101</cusip>
                <identifiers>
                    <isin value="US45253H1014"/>
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                <balance>1434700</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>8091708</valUSD>
                <pctVal>0.503502207587</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>MEDTRONIC PLC</name>
                <lei>549300GX3ZBSQWUXY261</lei>
                <title>COMMON STOCK</title>
                <cusip>G5960L103</cusip>
                <identifiers>
                    <isin value="IE00BTN1Y115"/>
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                <balance>171200</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>17974288</valUSD>
                <pctVal>1.118440468663</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>IE</invCountry>

                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>BAXTER INTERNATIONAL INC</name>
                <lei>J5OIVXX3P24RJRW5CK77</lei>
                <title>COMMON STOCK</title>
                <cusip>071813109</cusip>
                <identifiers>
                    <isin value="US0718131099"/>
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                <balance>202300</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>17189431</valUSD>
                <pctVal>1.069603161121</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>THERMO FISHER SCIENTIFIC INC</name>
                <lei>HCHV7422L5HDJZCRFL38</lei>
                <title>COMMON STOCK</title>
                <cusip>883556102</cusip>
                <identifiers>
                    <isin value="US8835561023"/>
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                <balance>124800</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>67891200</valUSD>
                <pctVal>4.224493651492</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>EDWARDS LIFESCIENCES CORP</name>
                <lei>YA13X31F3V31L8TMPR58</lei>
                <title>COMMON STOCK</title>
                <cusip>28176E108</cusip>
                <identifiers>
                    <isin value="US28176E1082"/>
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                <balance>137200</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>15417164</valUSD>
                <pctVal>0.959324793817</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>BOSTON SCIENTIFIC CORP</name>
                <lei>Y6ZDD9FP4P8JSSJMW954</lei>
                <title>COMMON STOCK</title>
                <cusip>101137107</cusip>
                <identifiers>
                    <isin value="US1011371077"/>
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                <balance>692200</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>30574474</valUSD>
                <pctVal>1.902480311303</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            <invstOrSec>
                <name>MERCK  AND  CO INC</name>
                <lei>4YV9Y5M8S0BRK1RP0397</lei>
                <title>COMMON STOCK</title>
                <cusip>58933Y105</cusip>
                <identifiers>
                    <isin value="US58933Y1055"/>
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                <balance>563338</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>43140424.04</valUSD>
                <pctVal>2.684389839621</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            <invstOrSec>
                <name>ELI LILLY  AND  CO</name>
                <lei>FRDRIPF3EKNDJ2CQJL29</lei>
                <title>COMMON STOCK</title>
                <cusip>532457108</cusip>
                <identifiers>
                    <isin value="US5324571083"/>
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                <balance>177700</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>44416115</valUSD>
                <pctVal>2.763769028113</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            <invstOrSec>
                <name>JOHNSON  AND  JOHNSON</name>
                <lei>549300G0CFPGEF6X2043</lei>
                <title>COMMON STOCK</title>
                <cusip>478160104</cusip>
                <identifiers>
                    <isin value="US4781601046"/>
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                <balance>514674</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>84699900.18</valUSD>
                <pctVal>5.270406040731</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>INTUITIVE SURGICAL INC</name>
                <lei>54930052SRG011710797</lei>
                <title>COMMON STOCK</title>
                <cusip>46120E602</cusip>
                <identifiers>
                    <isin value="US46120E6023"/>
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                <balance>107300</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>31152409</valUSD>
                <pctVal>1.938442007936</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>UNITED THERAPEUTICS CORP</name>
                <lei>5299005C4HZL4UWROC14</lei>
                <title>COMMON STOCK</title>
                <cusip>91307C102</cusip>
                <identifiers>
                    <isin value="US91307C1027"/>
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                <balance>80500</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>13379100</valUSD>
                <pctVal>0.832507350182</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>ABBOTT LABORATORIES</name>
                <lei>HQD377W2YR662HK5JX27</lei>
                <title>COMMON STOCK</title>
                <cusip>002824100</cusip>
                <identifiers>
                    <isin value="US0028241000"/>
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                <balance>518200</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>62505284</valUSD>
                <pctVal>3.889357905630</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>PFIZER INC</name>
                <lei>765LHXWGK1KXCLTFYQ30</lei>
                <title>COMMON STOCK</title>
                <cusip>717081103</cusip>
                <identifiers>
                    <isin value="US7170811035"/>
                </identifiers>
                <balance>1081840</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>50781569.6</valUSD>
                <pctVal>3.159856040076</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
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            </invstOrSec>
            <invstOrSec>
                <name>MCKESSON CORP</name>
                <lei>549300WZWOM80UCFSF54</lei>
                <title>COMMON STOCK</title>
                <cusip>58155Q103</cusip>
                <identifiers>
                    <isin value="US58155Q1031"/>
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                <balance>116500</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>32032840</valUSD>
                <pctVal>1.993226356572</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
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                    <isCashCollateral>N</isCashCollateral>
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                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>HUMANA INC</name>
                <lei>529900YLDW34GJAO4J06</lei>
                <title>COMMON STOCK</title>
                <cusip>444859102</cusip>
                <identifiers>
                    <isin value="US4448591028"/>
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                <balance>47300</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>20543336</valUSD>
                <pctVal>1.278298108039</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
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                <fairValLevel>1</fairValLevel>
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                    <isCashCollateral>N</isCashCollateral>
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            <invstOrSec>
                <name>SAREPTA THERAPEUTICS INC</name>
                <lei>549300IKDPIED8J8IG21</lei>
                <title>COMMON STOCK</title>
                <cusip>803607100</cusip>
                <identifiers>
                    <isin value="US8036071004"/>
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                <balance>58700</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>4497007</valUSD>
                <pctVal>0.279823858206</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
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                <fairValLevel>1</fairValLevel>
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                    <isCashCollateral>N</isCashCollateral>
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            <invstOrSec>
                <name>ASCENDIS PHARMA A/S</name>
                <lei>549300B66JN3W3J8GH73</lei>
                <title>COMMON STOCK - ADR</title>
                <cusip>04351P101</cusip>
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                    <isin value="US04351P1012"/>
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                <balance>200652</balance>
                <units>NS</units>
                <curCd>USD</curCd>
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                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>DK</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
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            <invstOrSec>
                <name>STATE STREET B AND T CO</name>
                <lei>571474TGEMMWANRLN572</lei>
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                    <other otherDesc="Internal ID" value="2566003"/>
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                <units>NC</units>
                <curCd>N/A</curCd>
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                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
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                <fairValLevel>2</fairValLevel>
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                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>STATE STREET B AND T CO</counterpartyName>
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            <invstOrSec>
                <name>STATE STREET B AND T CO</name>
                <lei>571474TGEMMWANRLN572</lei>
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                    <other otherDesc="Internal ID" value="2566014"/>
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                <units>NC</units>
                <curCd>N/A</curCd>
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                <fairValLevel>2</fairValLevel>
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                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>STATE STREET B AND T CO</counterpartyName>
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            <invstOrSec>
                <name>MORGAN STANLEY AND CO. INTERNATIONAL</name>
                <lei>4PQUHN3JPFGFNF3BB653</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2566016"/>
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                <balance>1</balance>
                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>15546086.6</valUSD>
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                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
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                <fairValLevel>2</fairValLevel>
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                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>MORGAN STANLEY AND CO. INTERNATIONAL</counterpartyName>
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                        <amtCurSold>15546086.6</amtCurSold>
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                        <curPur>GBP</curPur>
                        <settlementDt>2022-03-16</settlementDt>
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            <invstOrSec>
                <name>BANK OF AMERICA N.A.</name>
                <lei>B4TYDEB6GKMZO031MB27</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2566200"/>
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                <balance>1</balance>
                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>7059260.74</valUSD>
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                <assetCat>DFE</assetCat>
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                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
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                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>BANK OF AMERICA N.A.</counterpartyName>
                            <counterpartyLei>B4TYDEB6GKMZO031MB27</counterpartyLei>
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                        <amtCurSold>7059260.74</amtCurSold>
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                        <amtCurPur>7060768.6</amtCurPur>
                        <curPur>CHF</curPur>
                        <settlementDt>2022-03-16</settlementDt>
                        <unrealizedAppr>-1507.86</unrealizedAppr>
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            <invstOrSec>
                <name>HSBC BANK USA</name>
                <lei>1IE8VN30JCEQV1H4R804</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2566206"/>
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                <balance>1</balance>
                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>29692952.07</valUSD>
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                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>HSBC BANK USA</counterpartyName>
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                        <amtCurSold>29692952.07</amtCurSold>
                        <curSold>USD</curSold>
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                        <curPur>CHF</curPur>
                        <settlementDt>2022-03-16</settlementDt>
                        <unrealizedAppr>-15614.74</unrealizedAppr>
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            <invstOrSec>
                <name>CITIBANK N.A.</name>
                <lei>E57ODZWZ7FF32TWEFA76</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2566224"/>
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                <balance>1</balance>
                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>22534795.22</valUSD>
                <pctVal>1.402215594135</pctVal>
                <payoffProfile>N/A</payoffProfile>
                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>CITIBANK N.A.</counterpartyName>
                            <counterpartyLei>E57ODZWZ7FF32TWEFA76</counterpartyLei>
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                        <amtCurSold>22835295.13</amtCurSold>
                        <curSold>DKK</curSold>
                        <amtCurPur>22534795.22</amtCurPur>
                        <curPur>USD</curPur>
                        <settlementDt>2022-03-16</settlementDt>
                        <unrealizedAppr>300499.91</unrealizedAppr>
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            <invstOrSec>
                <name>CITIBANK N.A.</name>
                <lei>E57ODZWZ7FF32TWEFA76</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2566238"/>
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                <balance>1</balance>
                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>4647261.72</valUSD>
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                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
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                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>CITIBANK N.A.</counterpartyName>
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                        <amtCurSold>4707139.61</amtCurSold>
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                        <curPur>USD</curPur>
                        <settlementDt>2022-03-16</settlementDt>
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            <invstOrSec>
                <name>UBS AG</name>
                <lei>BFM8T61CT2L1QCEMIK50</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2566242"/>
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                <balance>1</balance>
                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>2576838.41</valUSD>
                <pctVal>0.160342393476</pctVal>
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                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>UBS AG</counterpartyName>
                            <counterpartyLei>BFM8T61CT2L1QCEMIK50</counterpartyLei>
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                        <amtCurSold>2610403.88</amtCurSold>
                        <curSold>EUR</curSold>
                        <amtCurPur>2576838.41</amtCurPur>
                        <curPur>USD</curPur>
                        <settlementDt>2022-03-16</settlementDt>
                        <unrealizedAppr>33565.47</unrealizedAppr>
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            <invstOrSec>
                <name>NATWEST MARKETS PLC</name>
                <lei>RR3QWICWWIPCS8A4S074</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2566246"/>
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                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>14666293.08</valUSD>
                <pctVal>0.912602251947</pctVal>
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                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>GB</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
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                            <counterpartyName>NATWEST MARKETS PLC</counterpartyName>
                            <counterpartyLei>RR3QWICWWIPCS8A4S074</counterpartyLei>
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                        <amtCurPur>14857948.2</amtCurPur>
                        <curPur>EUR</curPur>
                        <settlementDt>2022-03-16</settlementDt>
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            <invstOrSec>
                <name>BARCLAYS BANK PLC WHOLESALE, LONDON </name>
                <lei>G5GSEF7VJP5I7OUK5573</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
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                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>7796593.77</valUSD>
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                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>GB</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
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                            <counterpartyName>BARCLAYS BANK PLC WHOLESALE, LONDON </counterpartyName>
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                        <settlementDt>2022-03-16</settlementDt>
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            <invstOrSec>
                <name>HSBC BANK USA</name>
                <lei>1IE8VN30JCEQV1H4R804</lei>
                <title>CURRENCY FORWARDS</title>
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                <units>NC</units>
                <curCd>N/A</curCd>
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                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

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            <invstOrSec>
                <name>BANK OF AMERICA N.A.</name>
                <lei>B4TYDEB6GKMZO031MB27</lei>
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                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2566262"/>
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                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>24927537.6</valUSD>
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                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
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                            <counterpartyName>BANK OF AMERICA N.A.</counterpartyName>
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                        <settlementDt>2022-03-16</settlementDt>
                        <unrealizedAppr>-327368.3</unrealizedAppr>
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                    <isLoanByFund>N</isLoanByFund>
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            <invstOrSec>
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                <fairValLevel>2</fairValLevel>
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                    <fwdDeriv derivCat="FWD">
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                <fairValLevel>2</fairValLevel>
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                    <fwdDeriv derivCat="FWD">
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                <name>MORGAN STANLEY AND CO. INTERNATIONAL</name>
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                <name>GOLDMAN SACHS INTL FX</name>
                <lei>W22LROWP2IHZNBB6K528</lei>
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                <fairValLevel>2</fairValLevel>
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                    <fwdDeriv derivCat="FWD">
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            <invstOrSec>
                <name>WESTPAC BANKING CORPORATION</name>
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                <fairValLevel>2</fairValLevel>
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                    <fwdDeriv derivCat="FWD">
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            <invstOrSec>
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                <assetCat>DFE</assetCat>
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                <invCountry>US</invCountry>
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                <fairValLevel>2</fairValLevel>
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                    <fwdDeriv derivCat="FWD">
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            <invstOrSec>
                <name>CREDIT SUISSE INTERNATIONAL (FX)</name>
                <lei>E58DKGMJYYYJLN8C3868</lei>
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                <identifiers>
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                <curCd>N/A</curCd>
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                <issuerCat>CORP</issuerCat>
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                <fairValLevel>2</fairValLevel>
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            <invstOrSec>
                <name>UBS AG</name>
                <lei>BFM8T61CT2L1QCEMIK50</lei>
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                <fairValLevel>2</fairValLevel>
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                <name>MORGAN STANLEY AND CO. INTERNATIONAL</name>
                <lei>4PQUHN3JPFGFNF3BB653</lei>
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                <name>STATE STREET B AND T CO</name>
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                <name>GOLDMAN SACHS INTL FX</name>
                <lei>W22LROWP2IHZNBB6K528</lei>
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                <name>JP MORGANCHASE BANK</name>
                <lei>7H6GLXDRUGQFU57RNE97</lei>
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                    <fwdDeriv derivCat="FWD">
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            <invstOrSec>
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                <fairValLevel>2</fairValLevel>
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            <invstOrSec>
                <name>CITIBANK N.A.</name>
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            <invstOrSec>
                <name>HSBC BANK USA</name>
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            <invstOrSec>
                <name>STATE STREET B AND T CO</name>
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            <invstOrSec>
                <name>HSBC BANK USA</name>
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            <invstOrSec>
                <name>GOLDMAN SACHS INTL FX</name>
                <lei>W22LROWP2IHZNBB6K528</lei>
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                <assetCat>DFE</assetCat>
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                <invCountry>US</invCountry>
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                <fairValLevel>2</fairValLevel>
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                        <amtCurSold>35495110.17</amtCurSold>
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            <invstOrSec>
                <name>UBS AG</name>
                <lei>BFM8T61CT2L1QCEMIK50</lei>
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                <fairValLevel>2</fairValLevel>
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            <invstOrSec>
                <name>UBS AG</name>
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            <invstOrSec>
                <name>GOLDMAN SACHS INTL FX</name>
                <lei>W22LROWP2IHZNBB6K528</lei>
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                <name>TERRASCEND CORP</name>
                <lei>529900Z66HBZ5381EO49</lei>
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                <invCountry>CA</invCountry>
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                <lei>N/A</lei>
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                <name>NOVO NORDISK A/S</name>
                <lei>549300DAQ1CVT6CXN342</lei>
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                <invCountry>DK</invCountry>
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                <name>EISAI CO LTD</name>
                <lei>353800HDEE0ZYEX4QV91</lei>
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                <name>NOVARTIS AG</name>
                <lei>5493007HIVTX6SY6XD66</lei>
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                <fairValLevel>2</fairValLevel>
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                <name>TAKEDA PHARMACEUTICAL CO LTD</name>
                <lei>549300ZLMVP4X0OGR454</lei>
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                    <isin value="JP3463000004"/>
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                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>JP</invCountry>
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                <fairValLevel>2</fairValLevel>
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            <invstOrSec>
                <name>ASTELLAS PHARMA INC</name>
                <lei>529900IB708DY2HBBB35</lei>
                <title>ORDINARY SHARES</title>
                <cusip>J03393105</cusip>
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                    <isin value="JP3942400007"/>
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                <pctVal>0.476624485241</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>JP</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>MERCK KGAA</name>
                <lei>529900OAREIS0MOPTW25</lei>
                <title>ORDINARY SHARES</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <isin value="DE0006599905"/>
                </identifiers>
                <balance>67226</balance>
                <units>NS</units>
                <currencyConditional curCd="EUR" exchangeRt="1.1212497"/>
                <valUSD>13383450.68</valUSD>
                <pctVal>0.832778068921</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>DE</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>ICON PLC</name>
                <lei>6354008SRQGEMC4XFI67</lei>
                <title>ORDINARY SHARES</title>
                <cusip>G4705A100</cusip>
                <identifiers>
                    <isin value="IE0005711209"/>
                </identifiers>
                <balance>199500</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>47482995</valUSD>
                <pctVal>2.954603997740</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>IE</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>ASTRAZENECA PLC</name>
                <lei>PY6ZZQWO2IZFZC3IOL08</lei>
                <title>ORDINARY SHARES</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <isin value="GB0009895292"/>
                </identifiers>
                <balance>718010</balance>
                <units>NS</units>
                <currencyConditional curCd="GBP" exchangeRt="1.341500388"/>
                <valUSD>87086755.9</valUSD>
                <pctVal>5.418926862813</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>GB</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>CHUGAI PHARMACEUTICAL CO LTD</name>
                <lei>529900T9LAII161DCN95</lei>
                <title>ORDINARY SHARES</title>
                <cusip>J06930101</cusip>
                <identifiers>
                    <isin value="JP3519400000"/>
                </identifiers>
                <balance>158600</balance>
                <units>NS</units>
                <currencyConditional curCd="JPY" exchangeRt=".008698299"/>
                <valUSD>5256696.95</valUSD>
                <pctVal>0.327095159507</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>JP</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>SANOFI</name>
                <lei>549300E9PC51EN656011</lei>
                <title>ORDINARY SHARES</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <isin value="FR0000120578"/>
                </identifiers>
                <balance>487447</balance>
                <units>NS</units>
                <currencyConditional curCd="EUR" exchangeRt="1.1212497"/>
                <valUSD>51144094.62</valUSD>
                <pctVal>3.182413965779</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>FR</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>TERUMO CORPORATION</name>
                <lei>353800JX1R4582QVK932</lei>
                <title>ORDINARY SHARES</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <isin value="JP3546800008"/>
                </identifiers>
                <balance>141900</balance>
                <units>NS</units>
                <currencyConditional curCd="JPY" exchangeRt=".008698299"/>
                <valUSD>4602285.83</valUSD>
                <pctVal>0.286374777161</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>JP</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>ROCHE HOLDING AG</name>
                <lei>549300U41AUUVOAAOB37</lei>
                <title>ORDINARY SHARES</title>
                <cusip>H69293217</cusip>
                <identifiers>
                    <isin value="CH0012032048"/>
                </identifiers>
                <balance>155151</balance>
                <units>NS</units>
                <currencyConditional curCd="CHF" exchangeRt="1.090393632"/>
                <valUSD>59190485.12</valUSD>
                <pctVal>3.683096316138</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>CH</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>LONZA GROUP AG</name>
                <lei>549300EFW4H2TCZ71055</lei>
                <title>ORDINARY SHARES</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <isin value="CH0013841017"/>
                </identifiers>
                <balance>33269</balance>
                <units>NS</units>
                <currencyConditional curCd="CHF" exchangeRt="1.090393632"/>
                <valUSD>23124829.54</valUSD>
                <pctVal>1.438930164492</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>CH</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>DAIICHI SANKYO CO LTD</name>
                <lei>353800XGIU2IHQGC9504</lei>
                <title>ORDINARY SHARES</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <isin value="JP3475350009"/>
                </identifiers>
                <balance>381000</balance>
                <units>NS</units>
                <currencyConditional curCd="JPY" exchangeRt=".008698299"/>
                <valUSD>9291697.37</valUSD>
                <pctVal>0.578170905083</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>JP</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>PUTNAM CASH COLLATERAL POOL LLC</name>
                <lei>5493005HRIV7IFMKD774</lei>
                <title>SHORT TERM INV FUND</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="1181681"/>
                </identifiers>
                <balance>23768731</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>23768731</valUSD>
                <pctVal>1.478996588859</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>STIV</assetCat>
                <issuerCat>PF</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <cashCollateralCondition cashCollateralVal="23768731" isCashCollateral="Y"/>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>PUTNAM SHORT TERM INVESTMENT FUND</name>
                <lei>5493003MK0Q7JP8CPP42</lei>
                <title>SHORT TERM INV FUND</title>
                <cusip>74676P664</cusip>
                <identifiers>
                    <isin value="US74676P6640"/>
                </identifiers>
                <balance>32263360</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>32263360</valUSD>
                <pctVal>2.007570340424</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>STIV</assetCat>
                <issuerCat>PF</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>State Street Institutional U.S. Government Money Market Fund, Premier Class</name>
                <lei>N/A</lei>
                <title>SHORT TERM INV FUND</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="715802"/>
                </identifiers>
                <balance>545000</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>545000</valUSD>
                <pctVal>0.033912333853</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>STIV</assetCat>
                <issuerCat>RF</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>SARISSA CAPITAL ACQUISITION CORP</name>
                <lei>5493004KJWPWVA1PD410</lei>
                <title>STOCK UNIT</title>
                <cusip>G7823W128</cusip>
                <identifiers>
                    <isin value="KYG7823W1289"/>
                </identifiers>
                <balance>1721671</balance>
                <units>OU</units>
                <curCd>USD</curCd>
                <valUSD>16941242.64</valUSD>
                <pctVal>1.054159773006</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>UNITED STATES OF AMERICA</name>
                <lei>254900HROIFWPRGM1V77</lei>
                <title>U.S. T BILLS</title>
                <cusip>912796H44</cusip>
                <identifiers>
                    <isin value="US912796H440"/>
                </identifiers>
                <balance>700000</balance>
                <units>PA</units>
                <curCd>USD</curCd>
                <valUSD>699532.51</valUSD>
                <pctVal>0.043528036734</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>DBT</assetCat>
                <issuerCat>UST</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <debtSec>
                    <maturityDt>2022-05-19</maturityDt>
                    <couponKind>Fixed</couponKind>
                    <annualizedRt>0</annualizedRt>
                    <isDefault>N</isDefault>
                    <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
                    <isPaidKind>N</isPaidKind>
                </debtSec>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>UNITED STATES OF AMERICA</name>
                <lei>254900HROIFWPRGM1V77</lei>
                <title>U.S. T BILLS</title>
                <cusip>912796G45</cusip>
                <identifiers>
                    <isin value="US912796G459"/>
                </identifiers>
                <balance>3102000</balance>
                <units>PA</units>
                <curCd>USD</curCd>
                <valUSD>3101208.99</valUSD>
                <pctVal>0.192971072690</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>DBT</assetCat>
                <issuerCat>UST</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <debtSec>
                    <maturityDt>2022-04-21</maturityDt>
                    <couponKind>Fixed</couponKind>
                    <annualizedRt>0</annualizedRt>
                    <isDefault>N</isDefault>
                    <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
                    <isPaidKind>N</isPaidKind>
                </debtSec>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
        </invstOrSecs>
        <signature>
            <ncom:dateSigned>2022-04-26</ncom:dateSigned>
            <ncom:nameOfApplicant>Putnam Investments Inc</ncom:nameOfApplicant>
            <ncom:signature>Janet C. Smith</ncom:signature>
            <ncom:signerName>NPORT</ncom:signerName>
            <ncom:title>Principal Financial Officer</ncom:title>
        </signature>
    </formData>
    <documents>XXXX</documents>
</edgarSubmission>
