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                <balance>672000</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>81164160</valUSD>
                <pctVal>4.77004378855</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>ROCKET PHARMACEUTICALS INC</name>
                <lei>549300R7VV82YUIN4Y93</lei>
                <title>COMMON STOCK</title>
                <cusip>77313F106</cusip>
                <identifiers>
                    <isin value="US77313F1066"/>
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                <balance>171289</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>5859796.69</valUSD>
                <pctVal>0.344382136195</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
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                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>CIGNA CORP</name>
                <lei>549300VIWYMSIGT1U456</lei>
                <title>COMMON STOCK</title>
                <cusip>125523100</cusip>
                <identifiers>
                    <isin value="US1255231003"/>
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                <balance>44600</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>9439590</valUSD>
                <pctVal>0.554767740416</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
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                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>TURNING POINT THERAPEUTICS INC</name>
                <lei>N/A</lei>
                <title>COMMON STOCK</title>
                <cusip>90041T108</cusip>
                <identifiers>
                    <isin value="US90041T1088"/>
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                <balance>101000</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>7779020</valUSD>
                <pctVal>0.457175507416</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
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                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>4FRONT VENTURES CORP</name>
                <lei>N/A</lei>
                <title>COMMON STOCK</title>
                <cusip>35086B207</cusip>
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                    <isin value="CA35086B2075"/>
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                <balance>14830586</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>15990782.74</valUSD>
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                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
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            </invstOrSec>
            <invstOrSec>
                <name>HEALTH SCIENCES ACQUISITIONS CORP 2</name>
                <lei>N/A</lei>
                <title>COMMON STOCK</title>
                <cusip>G4411D109</cusip>
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                    <isin value="KYG4411D1097"/>
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                <balance>680995</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>6656726.13</valUSD>
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                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
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                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>GREEN THUMB INDUSTRIES INC</name>
                <lei>529900Q0L3K192QQY915</lei>
                <title>COMMON STOCK</title>
                <cusip>39342L108</cusip>
                <identifiers>
                    <isin value="CA39342L1085"/>
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                <balance>123300</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>3662010</valUSD>
                <pctVal>0.215217505536</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <loanByFundCondition isLoanByFund="Y" loanVal="32670"/>
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            <invstOrSec>
                <name>ALKERMES PLC</name>
                <lei>549300YHRMYLL071E243</lei>
                <title>COMMON STOCK</title>
                <cusip>G01767105</cusip>
                <identifiers>
                    <isin value="IE00B56GVS15"/>
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                <balance>378900</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>11844414</valUSD>
                <pctVal>0.696100020375</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>IE</invCountry>

                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>BIOGEN INC</name>
                <lei>W8J5WZB5IY3K0NDQT671</lei>
                <title>COMMON STOCK</title>
                <cusip>09062X103</cusip>
                <identifiers>
                    <isin value="US09062X1037"/>
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                <balance>96651</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>32755990.41</valUSD>
                <pctVal>1.925080091915</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>DANAHER CORP</name>
                <lei>S4BKK9OTCEWQ3YHPFM11</lei>
                <title>COMMON STOCK</title>
                <cusip>235851102</cusip>
                <identifiers>
                    <isin value="US2358511028"/>
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                <balance>248100</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>80424096</valUSD>
                <pctVal>4.726549989239</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>UNITEDHEALTH GROUP INC</name>
                <lei>549300GHBMY8T5GXDE41</lei>
                <title>COMMON STOCK</title>
                <cusip>91324P102</cusip>
                <identifiers>
                    <isin value="US91324P1021"/>
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                <balance>278900</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>116097703</valUSD>
                <pctVal>6.82309934656</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>BRISTOL-MYERS SQUIBB CO</name>
                <lei>HLYYNH7UQUORYSJQCN42</lei>
                <title>COMMON STOCK</title>
                <cusip>110122108</cusip>
                <identifiers>
                    <isin value="US1101221083"/>
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                <balance>398100</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>26616966</valUSD>
                <pctVal>1.564287652806</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>MEDTRONIC PLC</name>
                <lei>549300GX3ZBSQWUXY261</lei>
                <title>COMMON STOCK</title>
                <cusip>G5960L103</cusip>
                <identifiers>
                    <isin value="IE00BTN1Y115"/>
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                <balance>302700</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>40404396</valUSD>
                <pctVal>2.374579348445</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>IE</invCountry>

                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>BIO-RAD LABORATORIES INC</name>
                <lei>549300ZC1GPV35XYDK53</lei>
                <title>COMMON STOCK</title>
                <cusip>090572207</cusip>
                <identifiers>
                    <isin value="US0905722072"/>
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                <balance>32500</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>26156650</valUSD>
                <pctVal>1.537234733431</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>THERMO FISHER SCIENTIFIC INC</name>
                <lei>HCHV7422L5HDJZCRFL38</lei>
                <title>COMMON STOCK</title>
                <cusip>883556102</cusip>
                <identifiers>
                    <isin value="US8835561023"/>
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                <balance>124800</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>69257760</valUSD>
                <pctVal>4.070300831018</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>EDWARDS LIFESCIENCES CORP</name>
                <lei>YA13X31F3V31L8TMPR58</lei>
                <title>COMMON STOCK</title>
                <cusip>28176E108</cusip>
                <identifiers>
                    <isin value="US28176E1082"/>
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                <balance>327800</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>38411604</valUSD>
                <pctVal>2.257462321651</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            <invstOrSec>
                <name>MERCK  AND  CO INC</name>
                <lei>4YV9Y5M8S0BRK1RP0397</lei>
                <title>COMMON STOCK</title>
                <cusip>58933Y105</cusip>
                <identifiers>
                    <isin value="US58933Y1055"/>
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                <balance>507738</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>38735332.02</valUSD>
                <pctVal>2.276487921509</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>GILEAD SCIENCES INC</name>
                <lei>549300WTZWR07K8MNV44</lei>
                <title>COMMON STOCK</title>
                <cusip>375558103</cusip>
                <identifiers>
                    <isin value="US3755581036"/>
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                <balance>160000</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>11644800</valUSD>
                <pctVal>0.684368641392</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>REGENERON PHARMACEUTICALS INC</name>
                <lei>549300RCBFWIRX3HYQ56</lei>
                <title>COMMON STOCK</title>
                <cusip>75886F107</cusip>
                <identifiers>
                    <isin value="US75886F1075"/>
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                <balance>38621</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>26007381.4</valUSD>
                <pctVal>1.528462169799</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            <invstOrSec>
                <name>ELI LILLY  AND  CO</name>
                <lei>FRDRIPF3EKNDJ2CQJL29</lei>
                <title>COMMON STOCK</title>
                <cusip>532457108</cusip>
                <identifiers>
                    <isin value="US5324571083"/>
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                <balance>177700</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>45898133</valUSD>
                <pctVal>2.697448038921</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            <invstOrSec>
                <name>JOHNSON  AND  JOHNSON</name>
                <lei>549300G0CFPGEF6X2043</lei>
                <title>COMMON STOCK</title>
                <cusip>478160104</cusip>
                <identifiers>
                    <isin value="US4781601046"/>
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                <balance>514674</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>89105509.62</valUSD>
                <pctVal>5.236759459945</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>INTUITIVE SURGICAL INC</name>
                <lei>54930052SRG011710797</lei>
                <title>COMMON STOCK</title>
                <cusip>46120E602</cusip>
                <identifiers>
                    <isin value="US46120E6023"/>
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                <balance>17600</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>18542656</valUSD>
                <pctVal>1.089757857114</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>UNITED THERAPEUTICS CORP</name>
                <lei>5299005C4HZL4UWROC14</lei>
                <title>COMMON STOCK</title>
                <cusip>91307C102</cusip>
                <identifiers>
                    <isin value="US91307C1027"/>
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                <balance>80500</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>17297840</valUSD>
                <pctVal>1.016599620415</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>ABBOTT LABORATORIES</name>
                <lei>HQD377W2YR662HK5JX27</lei>
                <title>COMMON STOCK</title>
                <cusip>002824100</cusip>
                <identifiers>
                    <isin value="US0028241000"/>
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                <balance>394000</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>49789780</valUSD>
                <pctVal>2.926161384807</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>PFIZER INC</name>
                <lei>765LHXWGK1KXCLTFYQ30</lei>
                <title>COMMON STOCK</title>
                <cusip>717081103</cusip>
                <identifiers>
                    <isin value="US7170811035"/>
                </identifiers>
                <balance>1038140</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>47827109.8</valUSD>
                <pctVal>2.810814625887</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
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                    <isCashCollateral>N</isCashCollateral>
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            <invstOrSec>
                <name>MCKESSON CORP</name>
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                <fairValLevel>1</fairValLevel>
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            <invstOrSec>
                <name>HUMANA INC</name>
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                <assetCat>EC</assetCat>
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                <fairValLevel>1</fairValLevel>
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            <invstOrSec>
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                <assetCat>EC</assetCat>
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            <invstOrSec>
                <name>AMERISOURCEBERGEN CORP</name>
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            <invstOrSec>
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                <name>STATE STREET B AND T CO</name>
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                <name>UBS AG</name>
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            <invstOrSec>
                <name>CITIBANK N.A.</name>
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                <name>BANK OF AMERICA N.A.</name>
                <lei>B4TYDEB6GKMZO031MB27</lei>
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                    <other otherDesc="Internal ID" value="2516744"/>
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                <invCountry>US</invCountry>
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                <name>BANK OF AMERICA N.A.</name>
                <lei>B4TYDEB6GKMZO031MB27</lei>
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                <units>NC</units>
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                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
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            <invstOrSec>
                <name>GOLDMAN SACHS INTL FX</name>
                <lei>W22LROWP2IHZNBB6K528</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2516791"/>
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                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>14656234.06</valUSD>
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                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
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                            <counterpartyName>GOLDMAN SACHS INTL FX</counterpartyName>
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                        <settlementDt>2021-09-15</settlementDt>
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                <name>MORGAN STANLEY AND CO. INTERNATIONAL</name>
                <lei>4PQUHN3JPFGFNF3BB653</lei>
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                <units>NC</units>
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                <name>STATE STREET B AND T CO</name>
                <lei>571474TGEMMWANRLN572</lei>
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                <name>NATWEST MARKETS PLC</name>
                <lei>RR3QWICWWIPCS8A4S074</lei>
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                <lei>B4TYDEB6GKMZO031MB27</lei>
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            <invstOrSec>
                <name>HSBC BANK USA</name>
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                <name>WESTPAC BANKING CORPORATION</name>
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            <invstOrSec>
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                <name>STATE STREET B AND T CO</name>
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                <name>STATE STREET B AND T CO</name>
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                <curCd>N/A</curCd>
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                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
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                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>STATE STREET B AND T CO</counterpartyName>
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                <name>NATWEST MARKETS PLC</name>
                <lei>RR3QWICWWIPCS8A4S074</lei>
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                    <other otherDesc="Internal ID" value="2525422"/>
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                <curCd>N/A</curCd>
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                <issuerCat>CORP</issuerCat>
                <invCountry>GB</invCountry>
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                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>NATWEST MARKETS PLC</counterpartyName>
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                <name>UBS AG</name>
                <lei>BFM8T61CT2L1QCEMIK50</lei>
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                    <other otherDesc="Internal ID" value="2525641"/>
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                <units>NC</units>
                <curCd>N/A</curCd>
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                    <fwdDeriv derivCat="FWD">
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                <lei>1IE8VN30JCEQV1H4R804</lei>
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                    <other otherDesc="Internal ID" value="2525643"/>
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                <invCountry>US</invCountry>
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                <fairValLevel>2</fairValLevel>
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                    <fwdDeriv derivCat="FWD">
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            <invstOrSec>
                <name>JP MORGANCHASE BANK</name>
                <lei>7H6GLXDRUGQFU57RNE97</lei>
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                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
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                <fairValLevel>2</fairValLevel>
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                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>JP MORGANCHASE BANK</counterpartyName>
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            <invstOrSec>
                <name>BANK OF AMERICA N.A.</name>
                <lei>B4TYDEB6GKMZO031MB27</lei>
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                <cusip>N/A</cusip>
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                    <other otherDesc="Internal ID" value="2525812"/>
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                <balance>1</balance>
                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>4150594.54</valUSD>
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                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>BANK OF AMERICA N.A.</counterpartyName>
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                        <amtCurSold>4150594.54</amtCurSold>
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                        <settlementDt>2021-10-20</settlementDt>
                        <unrealizedAppr>-89476.49</unrealizedAppr>
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            </invstOrSec>
            <invstOrSec>
                <name>STATE STREET B AND T CO</name>
                <lei>571474TGEMMWANRLN572</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2531697"/>
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                <balance>1</balance>
                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>12956216.89</valUSD>
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                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>STATE STREET B AND T CO</counterpartyName>
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            <invstOrSec>
                <name>GOLDMAN SACHS INTL FX</name>
                <lei>W22LROWP2IHZNBB6K528</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2531699"/>
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                <balance>1</balance>
                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>37049886.92</valUSD>
                <pctVal>2.177433770882</pctVal>
                <payoffProfile>N/A</payoffProfile>
                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>GOLDMAN SACHS INTL FX</counterpartyName>
                            <counterpartyLei>W22LROWP2IHZNBB6K528</counterpartyLei>
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                        <amtCurSold>37049886.92</amtCurSold>
                        <curSold>USD</curSold>
                        <amtCurPur>36908945.12</amtCurPur>
                        <curPur>JPY</curPur>
                        <settlementDt>2021-11-17</settlementDt>
                        <unrealizedAppr>140941.8</unrealizedAppr>
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                    <isLoanByFund>N</isLoanByFund>
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            <invstOrSec>
                <name>CREDIT SUISSE INTERNATIONAL (FX)</name>
                <lei>E58DKGMJYYYJLN8C3868</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
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                <balance>1</balance>
                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>9167756.66</valUSD>
                <pctVal>0.538792007593</pctVal>
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                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>CREDIT SUISSE INTERNATIONAL (FX)</counterpartyName>
                            <counterpartyLei>E58DKGMJYYYJLN8C3868</counterpartyLei>
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                        <amtCurSold>9167756.66</amtCurSold>
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                        <curPur>JPY</curPur>
                        <settlementDt>2021-11-17</settlementDt>
                        <unrealizedAppr>33766.17</unrealizedAppr>
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                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>BANK OF AMERICA N.A.</name>
                <lei>B4TYDEB6GKMZO031MB27</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2533557"/>
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                <balance>1</balance>
                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>14584919.28</valUSD>
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                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>BANK OF AMERICA N.A.</counterpartyName>
                            <counterpartyLei>B4TYDEB6GKMZO031MB27</counterpartyLei>
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                        <settlementDt>2021-11-17</settlementDt>
                        <unrealizedAppr>-54231.88</unrealizedAppr>
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            <invstOrSec>
                <name>BARCLAYS BANK PLC WHOLESALE, LONDON </name>
                <lei>G5GSEF7VJP5I7OUK5573</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2533559"/>
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                <balance>1</balance>
                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>3189032.23</valUSD>
                <pctVal>0.187420449866</pctVal>
                <payoffProfile>N/A</payoffProfile>
                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>GB</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
                    <fwdDeriv derivCat="FWD">
                        <counterparties>
                            <counterpartyName>BARCLAYS BANK PLC WHOLESALE, LONDON </counterpartyName>
                            <counterpartyLei>G5GSEF7VJP5I7OUK5573</counterpartyLei>
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                        <amtCurSold>3189032.23</amtCurSold>
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                        <amtCurPur>3176968.74</amtCurPur>
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                        <settlementDt>2021-11-17</settlementDt>
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            <invstOrSec>
                <name>WESTPAC BANKING CORPORATION</name>
                <lei>EN5TNI6CI43VEPAMHL14</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2533561"/>
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                <balance>1</balance>
                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>1645822.35</valUSD>
                <pctVal>0.096725508866</pctVal>
                <payoffProfile>N/A</payoffProfile>
                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
                    <fwdDeriv derivCat="FWD">
                        <counterparties>
                            <counterpartyName>WESTPAC BANKING CORPORATION</counterpartyName>
                            <counterpartyLei>EN5TNI6CI43VEPAMHL14</counterpartyLei>
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                        <amtCurSold>1645822.35</amtCurSold>
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                        <settlementDt>2021-11-17</settlementDt>
                        <unrealizedAppr>6070.71</unrealizedAppr>
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            <invstOrSec>
                <name>UBS AG</name>
                <lei>BFM8T61CT2L1QCEMIK50</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2533563"/>
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                <balance>1</balance>
                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>8880237.09</valUSD>
                <pctVal>0.521894389987</pctVal>
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                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
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                            <counterpartyName>UBS AG</counterpartyName>
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            <invstOrSec>
                <name>JP MORGANCHASE BANK</name>
                <lei>7H6GLXDRUGQFU57RNE97</lei>
                <title>CURRENCY FORWARDS</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="2533567"/>
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                <balance>1</balance>
                <units>NC</units>
                <curCd>N/A</curCd>
                <valUSD>14713422.25</valUSD>
                <pctVal>0.864712558005</pctVal>
                <payoffProfile>N/A</payoffProfile>
                <assetCat>DFE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
                    <fwdDeriv derivCat="FWD">
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                            <counterpartyName>JP MORGANCHASE BANK</counterpartyName>
                            <counterpartyLei>7H6GLXDRUGQFU57RNE97</counterpartyLei>
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                        <amtCurSold>14659509.57</amtCurSold>
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                        <amtCurPur>14713422.25</amtCurPur>
                        <curPur>USD</curPur>
                        <settlementDt>2021-11-17</settlementDt>
                        <unrealizedAppr>-53912.68</unrealizedAppr>
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                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>EISAI CO LTD</name>
                <lei>353800HDEE0ZYEX4QV91</lei>
                <title>ORDINARY SHARES</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <isin value="JP3160400002"/>
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                <balance>57400</balance>
                <units>NS</units>
                <currencyConditional curCd="JPY" exchangeRt=".00908967"/>
                <valUSD>4739128.71</valUSD>
                <pctVal>0.278520118563</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>JP</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>LONZA GROUP AG</name>
                <lei>549300EFW4H2TCZ71055</lei>
                <title>ORDINARY SHARES</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <isin value="CH0013841017"/>
                </identifiers>
                <balance>33269</balance>
                <units>NS</units>
                <currencyConditional curCd="CHF" exchangeRt="1.092001092"/>
                <valUSD>28155582.86</valUSD>
                <pctVal>1.654712660543</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>CH</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>ROCHE HOLDING AG</name>
                <lei>549300U41AUUVOAAOB37</lei>
                <title>ORDINARY SHARES</title>
                <cusip>H69293217</cusip>
                <identifiers>
                    <isin value="CH0012032048"/>
                </identifiers>
                <balance>124401</balance>
                <units>NS</units>
                <currencyConditional curCd="CHF" exchangeRt="1.092001092"/>
                <valUSD>49957376.74</valUSD>
                <pctVal>2.936011099122</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>CH</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>TERUMO CORPORATION</name>
                <lei>353800JX1R4582QVK932</lei>
                <title>ORDINARY SHARES</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <isin value="JP3546800008"/>
                </identifiers>
                <balance>141900</balance>
                <units>NS</units>
                <currencyConditional curCd="JPY" exchangeRt=".00908967"/>
                <valUSD>5924761.81</valUSD>
                <pctVal>0.348200157193</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>JP</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>SANOFI</name>
                <lei>549300E9PC51EN656011</lei>
                <title>ORDINARY SHARES</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <isin value="FR0000120578"/>
                </identifiers>
                <balance>487447</balance>
                <units>NS</units>
                <currencyConditional curCd="EUR" exchangeRt="1.180750461"/>
                <valUSD>50429977.53</valUSD>
                <pctVal>2.963785999556</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>FR</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>CHUGAI PHARMACEUTICAL CO LTD</name>
                <lei>529900T9LAII161DCN95</lei>
                <title>ORDINARY SHARES</title>
                <cusip>J06930101</cusip>
                <identifiers>
                    <isin value="JP3519400000"/>
                </identifiers>
                <balance>158600</balance>
                <units>NS</units>
                <currencyConditional curCd="JPY" exchangeRt=".00908967"/>
                <valUSD>6202556.39</valUSD>
                <pctVal>0.364526234008</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>JP</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>GLAXOSMITHKLINE PLC</name>
                <lei>5493000HZTVUYLO1D793</lei>
                <title>ORDINARY SHARES</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <isin value="GB0009252882"/>
                </identifiers>
                <balance>921895</balance>
                <units>NS</units>
                <currencyConditional curCd="GBP" exchangeRt="1.374850141"/>
                <valUSD>18530374.43</valUSD>
                <pctVal>1.089036065294</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>GB</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>ASTRAZENECA PLC</name>
                <lei>PY6ZZQWO2IZFZC3IOL08</lei>
                <title>ORDINARY SHARES</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <isin value="GB0009895292"/>
                </identifiers>
                <balance>830135</balance>
                <units>NS</units>
                <currencyConditional curCd="GBP" exchangeRt="1.374850141"/>
                <valUSD>97171237.45</valUSD>
                <pctVal>5.710784878746</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>GB</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>ICON PLC</name>
                <lei>6354008SRQGEMC4XFI67</lei>
                <title>ORDINARY SHARES</title>
                <cusip>G4705A100</cusip>
                <identifiers>
                    <isin value="IE0005711209"/>
                </identifiers>
                <balance>147500</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>37726075</valUSD>
                <pctVal>2.21717356183</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>IE</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <loanByFundCondition isLoanByFund="Y" loanVal="2046160"/>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>MERCK KGAA</name>
                <lei>529900OAREIS0MOPTW25</lei>
                <title>ORDINARY SHARES</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <isin value="DE0006599905"/>
                </identifiers>
                <balance>80992</balance>
                <units>NS</units>
                <currencyConditional curCd="EUR" exchangeRt="1.180750461"/>
                <valUSD>19241025.88</valUSD>
                <pctVal>1.130801279582</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>DE</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>ASTELLAS PHARMA INC</name>
                <lei>529900IB708DY2HBBB35</lei>
                <title>ORDINARY SHARES</title>
                <cusip>J03393105</cusip>
                <identifiers>
                    <isin value="JP3942400007"/>
                </identifiers>
                <balance>457000</balance>
                <units>NS</units>
                <currencyConditional curCd="JPY" exchangeRt=".00908967"/>
                <valUSD>7707837.28</valUSD>
                <pctVal>0.452992076067</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>JP</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>TAKEDA PHARMACEUTICAL CO LTD</name>
                <lei>549300ZLMVP4X0OGR454</lei>
                <title>ORDINARY SHARES</title>
                <cusip>J81281115</cusip>
                <identifiers>
                    <isin value="JP3463000004"/>
                </identifiers>
                <balance>361900</balance>
                <units>NS</units>
                <currencyConditional curCd="JPY" exchangeRt=".00908967"/>
                <valUSD>12071265.8</valUSD>
                <pctVal>0.709432173625</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>JP</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>INMODE LTD</name>
                <lei>N/A</lei>
                <title>ORDINARY SHARES</title>
                <cusip>M5425M103</cusip>
                <identifiers>
                    <isin value="IL0011595993"/>
                </identifiers>
                <balance>84800</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>11098624</valUSD>
                <pctVal>0.652269702202</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>IL</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>TERRASCEND CORP</name>
                <lei>529900Z66HBZ5381EO49</lei>
                <title>ORDINARY SHARES</title>
                <cusip>88105E108</cusip>
                <identifiers>
                    <isin value="CA88105E1088"/>
                </identifiers>
                <balance>1454700</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>10241088</valUSD>
                <pctVal>0.601872035667</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>CA</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>NOVO NORDISK A/S</name>
                <lei>549300DAQ1CVT6CXN342</lei>
                <title>ORDINARY SHARES</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <isin value="DK0060534915"/>
                </identifiers>
                <balance>198176</balance>
                <units>NS</units>
                <currencyConditional curCd="DKK" exchangeRt=".158775523"/>
                <valUSD>19750893.14</valUSD>
                <pctVal>1.160766342444</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>DK</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>DAIICHI SANKYO CO LTD</name>
                <lei>353800XGIU2IHQGC9504</lei>
                <title>ORDINARY SHARES</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <isin value="JP3475350009"/>
                </identifiers>
                <balance>381000</balance>
                <units>NS</units>
                <currencyConditional curCd="JPY" exchangeRt=".00908967"/>
                <valUSD>9045469.62</valUSD>
                <pctVal>0.53160515892</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>JP</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>NOVARTIS AG</name>
                <lei>5493007HIVTX6SY6XD66</lei>
                <title>ORDINARY SHARES</title>
                <cusip>H5820Q150</cusip>
                <identifiers>
                    <isin value="CH0012005267"/>
                </identifiers>
                <balance>321114</balance>
                <units>NS</units>
                <currencyConditional curCd="CHF" exchangeRt="1.092001092"/>
                <valUSD>29732193.35</valUSD>
                <pctVal>1.747370566136</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>CH</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>PUTNAM SHORT TERM INVESTMENT FUND</name>
                <lei>5493003MK0Q7JP8CPP42</lei>
                <title>SHORT TERM INV FUND</title>
                <cusip>74676P664</cusip>
                <identifiers>
                    <isin value="US74676P6640"/>
                </identifiers>
                <balance>48921443</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>48921443</valUSD>
                <pctVal>2.875128940028</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>STIV</assetCat>
                <issuerCat>PF</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>PUTNAM CASH COLLATERAL POOL LLC</name>
                <lei>5493005HRIV7IFMKD774</lei>
                <title>SHORT TERM INV FUND</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="1181681"/>
                </identifiers>
                <balance>64057850</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>64057850</valUSD>
                <pctVal>3.764700447838</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>STIV</assetCat>
                <issuerCat>PF</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <securityLending>
                    <cashCollateralCondition cashCollateralVal="64057850" isCashCollateral="Y"/>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>State Street Institutional U.S. Government Money Market Fund, Premier Class</name>
                <lei>N/A</lei>
                <title>SHORT TERM INV FUND</title>
                <cusip>N/A</cusip>
                <identifiers>
                    <other otherDesc="Internal ID" value="715802"/>
                </identifiers>
                <balance>1545000</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>1545000</valUSD>
                <pctVal>0.090800146928</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>STIV</assetCat>
                <issuerCat>RF</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
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            </invstOrSec>
            <invstOrSec>
                <name>SARISSA CAPITAL ACQUISITION CORP</name>
                <lei>5493004KJWPWVA1PD410</lei>
                <title>STOCK UNIT</title>
                <cusip>G7823W128</cusip>
                <identifiers>
                    <isin value="KYG7823W1289"/>
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                <balance>1721671</balance>
                <units>OU</units>
                <curCd>USD</curCd>
                <valUSD>17199493.29</valUSD>
                <pctVal>1.010819752637</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>EC</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>1</fairValLevel>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>UNITED STATES OF AMERICA</name>
                <lei>254900HROIFWPRGM1V77</lei>
                <title>U.S. T BILLS</title>
                <cusip>9127964V8</cusip>
                <identifiers>
                    <isin value="US9127964V80"/>
                </identifiers>
                <balance>200000</balance>
                <units>PA</units>
                <curCd>USD</curCd>
                <valUSD>199991.5</valUSD>
                <pctVal>0.01175356478</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>DBT</assetCat>
                <issuerCat>UST</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <debtSec>
                    <maturityDt>2021-10-07</maturityDt>
                    <couponKind>Fixed</couponKind>
                    <annualizedRt>0</annualizedRt>
                    <isDefault>N</isDefault>
                    <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
                    <isPaidKind>N</isPaidKind>
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                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>UNITED STATES OF AMERICA</name>
                <lei>254900HROIFWPRGM1V77</lei>
                <title>U.S. T BILLS</title>
                <cusip>912796L31</cusip>
                <identifiers>
                    <isin value="US912796L319"/>
                </identifiers>
                <balance>400000</balance>
                <units>PA</units>
                <curCd>USD</curCd>
                <valUSD>399995.3</valUSD>
                <pctVal>0.023507852434</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>DBT</assetCat>
                <issuerCat>UST</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <debtSec>
                    <maturityDt>2021-09-14</maturityDt>
                    <couponKind>Fixed</couponKind>
                    <annualizedRt>0</annualizedRt>
                    <isDefault>N</isDefault>
                    <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
                    <isPaidKind>N</isPaidKind>
                </debtSec>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>UNITED STATES OF AMERICA</name>
                <lei>254900HROIFWPRGM1V77</lei>
                <title>U.S. T BILLS</title>
                <cusip>912796N62</cusip>
                <identifiers>
                    <isin value="US912796N620"/>
                </identifiers>
                <balance>256000</balance>
                <units>PA</units>
                <curCd>USD</curCd>
                <valUSD>255974.06</valUSD>
                <pctVal>0.015043677837</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>DBT</assetCat>
                <issuerCat>UST</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <debtSec>
                    <maturityDt>2021-11-16</maturityDt>
                    <couponKind>Fixed</couponKind>
                    <annualizedRt>0</annualizedRt>
                    <isDefault>N</isDefault>
                    <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
                    <isPaidKind>N</isPaidKind>
                </debtSec>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>UNITED STATES OF AMERICA</name>
                <lei>254900HROIFWPRGM1V77</lei>
                <title>U.S. T BILLS</title>
                <cusip>912796M48</cusip>
                <identifiers>
                    <isin value="US912796M481"/>
                </identifiers>
                <balance>3000000</balance>
                <units>PA</units>
                <curCd>USD</curCd>
                <valUSD>2999810.02</valUSD>
                <pctVal>0.176299799724</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>DBT</assetCat>
                <issuerCat>UST</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <debtSec>
                    <maturityDt>2021-10-19</maturityDt>
                    <couponKind>Fixed</couponKind>
                    <annualizedRt>0</annualizedRt>
                    <isDefault>N</isDefault>
                    <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
                    <isPaidKind>N</isPaidKind>
                </debtSec>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>UNITED STATES OF AMERICA</name>
                <lei>254900HROIFWPRGM1V77</lei>
                <title>U.S. T. NOTE</title>
                <cusip>912828ZW3</cusip>
                <identifiers>
                    <isin value="US912828ZW33"/>
                </identifiers>
                <balance>278000</balance>
                <units>PA</units>
                <curCd>USD</curCd>
                <valUSD>274550.02</valUSD>
                <pctVal>0.016135392981</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>DBT</assetCat>
                <issuerCat>UST</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <debtSec>
                    <maturityDt>2025-06-30</maturityDt>
                    <couponKind>Fixed</couponKind>
                    <annualizedRt>.25</annualizedRt>
                    <isDefault>N</isDefault>
                    <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
                    <isPaidKind>N</isPaidKind>
                </debtSec>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>UNITED STATES OF AMERICA</name>
                <lei>254900HROIFWPRGM1V77</lei>
                <title>U.S. T. NOTE</title>
                <cusip>912828YS3</cusip>
                <identifiers>
                    <isin value="US912828YS30"/>
                </identifiers>
                <balance>127000</balance>
                <units>PA</units>
                <curCd>USD</curCd>
                <valUSD>133395.72</valUSD>
                <pctVal>0.007839709369</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>DBT</assetCat>
                <issuerCat>UST</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <debtSec>
                    <maturityDt>2029-11-15</maturityDt>
                    <couponKind>Fixed</couponKind>
                    <annualizedRt>1.75</annualizedRt>
                    <isDefault>N</isDefault>
                    <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
                    <isPaidKind>N</isPaidKind>
                </debtSec>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>UNITED STATES OF AMERICA</name>
                <lei>254900HROIFWPRGM1V77</lei>
                <title>U.S. T. NOTE</title>
                <cusip>91282CBC4</cusip>
                <identifiers>
                    <isin value="US91282CBC47"/>
                </identifiers>
                <balance>100000</balance>
                <units>PA</units>
                <curCd>USD</curCd>
                <valUSD>98744</valUSD>
                <pctVal>0.00580321664</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>DBT</assetCat>
                <issuerCat>UST</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>N</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <debtSec>
                    <maturityDt>2025-12-31</maturityDt>
                    <couponKind>Fixed</couponKind>
                    <annualizedRt>.375</annualizedRt>
                    <isDefault>N</isDefault>
                    <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
                    <isPaidKind>N</isPaidKind>
                </debtSec>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
            <invstOrSec>
                <name>PALISADE BIO INC</name>
                <lei>549300W6LIDX3I5XXT34</lei>
                <title>WARRANTS</title>
                <cusip>ACI0THRS6</cusip>
                <identifiers>
                    <ticker value="PVTACI0THRS6"/>
                </identifiers>
                <balance>18887</balance>
                <units>NS</units>
                <curCd>USD</curCd>
                <valUSD>0</valUSD>
                <pctVal>0</pctVal>
                <payoffProfile>Long</payoffProfile>
                <assetCat>DE</assetCat>
                <issuerCat>CORP</issuerCat>
                <invCountry>US</invCountry>
                <isRestrictedSec>Y</isRestrictedSec>

                <fairValLevel>2</fairValLevel>
                <derivativeInfo>
                    <optionSwaptionWarrantDeriv derivCat="WAR">
                        <counterparties>
                            <counterpartyName>PALISADE BIO INC</counterpartyName>
                            <counterpartyLei>549300W6LIDX3I5XXT34</counterpartyLei>
                        </counterparties>
                        <putOrCall>Call</putOrCall>
                        <writtenOrPur>Purchased</writtenOrPur>
                        <descRefInstrmnt>
                            <otherRefInst>
<issuerName>PALISADE BIO INC</issuerName>
<issueTitle>COMMON STOCK</issueTitle>
<identifiers>
    <cusip value="696389105"/>
</identifiers>
                            </otherRefInst>
                        </descRefInstrmnt>
                        <shareNo>1</shareNo>
                        <exercisePrice>946.4</exercisePrice>
                        <exercisePriceCurCd>USD</exercisePriceCurCd>
                        <expDt>2022-01-09</expDt>
                        <delta>XXXX</delta>
                        <unrealizedAppr>-0.25</unrealizedAppr>
                    </optionSwaptionWarrantDeriv>
                </derivativeInfo>
                <securityLending>
                    <isCashCollateral>N</isCashCollateral>
                    <isNonCashCollateral>N</isNonCashCollateral>
                    <isLoanByFund>N</isLoanByFund>
                </securityLending>
            </invstOrSec>
        </invstOrSecs>
        <signature>
            <ncom:dateSigned>2021-10-26</ncom:dateSigned>
            <ncom:nameOfApplicant>Putnam Investments Inc</ncom:nameOfApplicant>
            <ncom:signature>Janet C. Smith</ncom:signature>
            <ncom:signerName>NPORT</ncom:signerName>
            <ncom:title>Principal Financial Officer</ncom:title>
        </signature>
    </formData>
    <documents>XXXX</documents>
</edgarSubmission>
